1. [Thiazolidinediones and PPARgamma system in repair of liver damage]
- Author
-
Fabio, Marra and Sabrina, Pastacaldi
- Subjects
Inflammation ,Liver Cirrhosis ,Arteriosclerosis ,Research ,Anti-Inflammatory Agents, Non-Steroidal ,Fatty Acids ,Receptors, Cytoplasmic and Nuclear ,Antineoplastic Agents ,In Vitro Techniques ,Antioxidants ,Thiazoles ,Troglitazone ,Diabetes Mellitus, Type 2 ,Neoplasms ,Eicosanoids ,Humans ,Hypoglycemic Agents ,Thiazolidinediones ,Obesity ,Chromans ,Forecasting ,Transcription Factors - Abstract
PPAR-gamma belongs to the nuclear hormone receptor superfamily and its ligands include antidiabetic drugs of the thiazolidindione class, and endogenous molecules, including eicosanoids and fatty acids. PPAR-gamma is involved in the pathophysiology of obesity and type II diabetes. More recently, accumulating evidence suggests its role in atherosclerosis, inflammation and cancer. Recent data obtained in cellular models of liver fibrosis indicate that PPAR-gamma activation results in the inhibition of the processes leading to the development of liver fibrosis. These studies identify potential novel therapeutic strategies for the treatment of liver fibrosis.
- Published
- 2002