B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event In a study of patients recruited between January 2010 and September 2019, 15 patients (10 women and 5 men) aged 29-76 years were described, who developed DRESS syndrome during treatment with vancomycin for various infections [ I dosages, routes, duration of treatments to reaction onsets and outcomes not stated i ]. The patients had culture-negative soft-tissue infection with underlying rib osteomyelitis (1 patient), methicillin-resistant I Staphylococcus aureus i (MRSA) right chest phlegmon, deep soft-tissue infection, underlying osteomyelitis of second rib with fracture (1 patient), MRSA and I Escherichia coli i bacteraemia with chest infiltrate (1 patient), MRSA wound infection leading to hip prosthesis removal and placement of vancomycin spacer (1 patient), complex ocular infection (1 patient), soft tissue cellulitis (1 patient), MRSA wound infection (1 patient), I Enterococcus faecalis i pyelonephritis (1 patient), ventriculitis-empirical culture negative (2 patients), post-cardiac surgery wound infection-culture negative (1 patient), I Enterococcus i species bacteraemia and endocarditis (1 patient), MRSA osteomyelitis (1 patient), traumatic arm injury and possible osteomyelitis (1 patient), skin and soft tissue infection-methicillin-susceptible I Staphylococcus aureus i (1 patient). Seven of the 15 patients were treated with prednisone (6 patients) and unspecified high-dose steroids (1 patient). [Extracted from the article]