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A 65-year-old woman experienced lack of efficacy during treatment with ceftriaxone for a Staphylococcus aureus infection. She had a history of breast cancer and developed an abscess at the surgical site of a mastectomy, which did not respond to the antibiotic treatment. Despite undergoing abscess incision and drainage, her lymphedema persisted. The case highlights the challenges of treating infections in patients with complex medical histories. [Extracted from the article]

A case report published in Reactions Weekly describes a 29-year-old man who developed malignant hyperthermia (MH) during treatment with suxamethonium-chloride. The patient also exhibited lack of efficacy with dantrolene and sodium bicarbonate for MH. The man initially presented with a sore throat and was diagnosed with Ludwig's angina. After receiving treatment and undergoing surgery, he developed symptoms of MH, including increased heart rate, elevated temperature, muscle rigidity, and darkening urine. Despite receiving dantrolene and sodium bicarbonate, his temperature continued to rise. He was eventually stabilized and underwent abscess drainage without any residual complications. [Extracted from the article]

A 56-year-old man with stage IVb keratinising squamous cell carcinoma (SCC) of the natal cleft skin experienced lack of efficacy during treatment with cisplatin and developed toxic epidermal necrolysis during treatment with cemiplimab. The man underwent surgical procedures and developed metastases in the lymph nodes, lung, liver, and abdominal wall. Despite treatment with cisplatin and cemiplimab, his condition worsened, and he eventually died. The case highlights the challenges and complications associated with treating advanced SCC. [Extracted from the article]

This article describes two case reports of women who developed a florid histiocytic reaction during surgery while being treated with oxidized-regenerated-cellulose (ORC) as a hemostatic agent. The first patient had a history of bilateral ovarian endometriosis and underwent excision of ovarian cysts. The second patient had a history of a large right ovarian follicular cyst and underwent excision of tubo-ovarian adhesions. In both cases, the histopathologic examination revealed sheets of large cells with pale bluish cytoplasm and small displaced nuclei, confirming the histiocytic nature of the cells. The inflammatory response was only observed in the surgical sites where ORC was used, leading to the diagnosis of a florid histiocytic reaction associated with ORC. [Extracted from the article]

A 74-year-old patient experienced a lack of efficacy during treatment with vancomycin for a postoperative prosthetic joint infection and knee arthroplasty caused by M. gnavus. The patient had a medical history of high blood pressure, hypertrophic cardiomyopathy, and knee and hip arthroplasty. After receiving empiric treatment with ceftazidime and daptomycin, the diagnosis of Mediterraneibacter gnavus infection was confirmed. The antibiotic regimen was adjusted multiple times, and the patient underwent debridement, antibiotics, and implant retention (DAIR). Eventually, the patient showed improvement and was discharged after six weeks of treatment. Follow-up visits showed no signs of infection and adequate wound healing. No gastrointestinal complications were reported despite the prolonged use of antibiotics. [Extracted from the article]

A 70-year-old woman experienced iatrogenic tracheal rupture after receiving nitrous-oxide/oxygen during anesthesia for a surgical procedure. The woman had a history of various medical conditions and surgeries. After the operation, she developed swelling and crepitus in her face and neck, indicating subcutaneous emphysema. Radiological examination confirmed a tracheal injury, and she underwent emergency surgery to repair the rupture. She recovered without complications and was discharged from the hospital five days later. [Extracted from the article]

A 38-year-old woman with a history of chronic inflammatory demyelinating polyneuropathy (CIDP) experienced lack of efficacy and developed extensive arm skin necrosis at the site of heparin injection. Despite receiving prophylactic heparin, doppler ultrasonography showed cephalic venous thrombosis. Her heparin dose was changed to a therapeutic dose, but she developed progressive, inflamed, and tender lesions at the injection site, which eventually turned into extensive skin necrosis. Heparin was discontinued, and the woman was started on rivaroxaban. Her skin necrosis resolved without surgical intervention, and she was discharged after completing treatment for CIDP. [Extracted from the article]

A 50-year-old man with oesophageal squamous cell carcinoma experienced drug ineffectiveness while being treated with somatostatin for chylothorax. After undergoing thoraco-laparoscopic esophagectomy for his cancer, the man developed chylothorax and received conservative treatments, including somatostatin. However, the somatostatin treatment was ineffective, and the drainage fluid continued to increase. The man then underwent emergency right thoracic duct ligation, which successfully reduced the fluid drainage and improved his condition. He experienced no further complications and was discharged after surgery. [Extracted from the article]

A case report published in Reactions Weekly describes a male patient in his 70s who exhibited lack of efficacy during treatment with amphotericin B liposomal for abdominal wall mucormycosis infection. The patient had a history of chronic obstructive pulmonary disease and previously treated throat cancer. Despite receiving treatment with IV amphotericin B liposomal, the patient's fungal infection persisted and eventually led to his death on day 20. This case highlights the need for further research and alternative treatment options for mucormycosis infections. [Extracted from the article]

This article discusses three case reports of patients who experienced medication-related osteonecrosis of the jaw (MRONJ) while undergoing treatment with zoledronic acid for skeletal-related events. One patient also exhibited lack of efficacy during treatment with goserelin, finasteride, and enzalutamide for advanced prostate cancer. The first patient underwent surgical intervention and experienced successful recovery, while the second patient unfortunately passed away after conservative management. The third patient declined surgical intervention and ultimately succumbed to metastatic prostate cancer. These cases highlight the potential risks and complications associated with these medications. [Extracted from the article]

An 11-year-old boy with osteosarcoma exhibited lack of efficacy to ifosfamide treatment, and subsequently developed a surgical site infection (SSI) caused by Rhizopus caespitosus during treatment with gemcitabine and docetaxel. The boy underwent emergency craniotomy for an intracranial tumor hemorrhage and developed mild erythema at the surgical site, prompting a wound culture. The culture confirmed SSI caused by Rhizopus caespitosus, and the boy was treated with amphotericin-B-liposomal for 4 weeks, followed by posaconazole and then switched back to amphotericin-B-liposomal. His SSI was controlled for 4 months, but he ultimately died due to the progression of osteosarcoma. [Extracted from the article]

In a case series involving a 8-year-old boy with a complex medical history, it was found that treatment with silver nitrate and triamcinolone for granulation tissue was ineffective. The boy had multiple genetic abnormalities and congenital heart disease, and had undergone operative repair and the insertion of a gastrostomy tube. Despite receiving treatment, the granulation tissue around the tube site did not respond to the silver nitrate and triamcinolone. However, after undergoing tube site resection, the boy did not experience any further issues related to the surgical site. [Extracted from the article]

A 33-year-old man experienced skin necrosis after receiving an incorrect administration of buprenorphine for his opioid use disorder. Instead of receiving a subcutaneous injection, he unintentionally received a dermal extended-release injection. He quickly noticed pain and unusual skin changes and returned to the clinic, where he was diagnosed with skin necrosis. The man underwent surgical removal of the buprenorphine depot, which healed without complications. It was determined that the skin necrosis was a result of a medication error. [Extracted from the article]

A 70-year-old woman experienced blurred vision, hallucinations, and sleeplessness while being treated with voriconazole for Aspergillus tubingensis spondylitis. Prior to this, she had been admitted to the hospital with back and chest pain and limited mobility. She had also been diagnosed with tuberculosis and was receiving treatment for it. After starting voriconazole, she developed the aforementioned symptoms, which were determined to be related to the medication. Her dosage of voriconazole was adjusted and she was discharged in stable condition. [Extracted from the article]

A 51-year-old man developed Stevens-Johnson Syndrome (SJS) while being treated with cotrimoxazole for a urinary tract infection (UTI) and off-label use of levetiracetam for anxiety. The man had a history of previous surgeries and complications. He presented to the hospital with abdominal pain and a blistering skin rash on his face, lips, neck, and hands. He was diagnosed with SJS based on symptoms and skin biopsy results. Treatment involved stopping the levetiracetam and aciclovir, and providing symptomatic and supportive care. The man's skin rash eventually healed with some residual erythema. [Extracted from the article]

A 12-year-old boy with anaplastic pleomorphic xanthoastrocytoma (APXA) underwent treatment with temozolomide, an off-label drug. Despite receiving cranial radiation therapy and temozolomide, post-treatment imaging showed progressive disease. The boy then underwent a second surgery and received alternative off-label treatments, including cyclophosphamide, lomustine, vincristine, and procarbazine. After completing 12 years of treatment, the boy remained alive without any recurrent disease. [Extracted from the article]

A 46-year-old woman experienced polymorphic ventricular tachycardia and prolonged QTc interval after receiving a combination of epinephrine and desflurane. The woman was scheduled for surgery to treat a pituitary macroadenoma. During the procedure, the woman's heart rate increased rapidly and she developed ventricular tachycardia. The arrhythmias were transient and resolved after treatment. The interaction between epinephrine and desflurane was determined to be the cause of the cardiac events. The woman recovered well and was discharged from the hospital. [Extracted from the article]

A retrospective cohort study involving 12 patients who underwent spine surgery found that they developed delayed pseudomeningocele formation after receiving off-label therapy with triamcinolone via an unapproved route. The patients experienced symptoms such as orthostatic headache, swelling, and sciatica, and were diagnosed with delayed pseudomeningocele formation. They underwent revision surgeries and bed rest, and improvements in their conditions were noted. This study highlights the potential risks associated with off-label use of triamcinolone for lumbar disc herniation, foraminal stenosis, or facet joint cyst. [Extracted from the article]

A case report published in Reactions Weekly describes a male patient who developed a foreign body reaction after using aminolevulinic-acid, oxidised-cellulose, and fibrinogen/thrombin as sutures to close a surgical wound. The patient experienced symptoms such as headache, nausea, vomiting, sensitivity loss, and speaking difficulties. He was diagnosed with a right frontoparietal lesion and underwent surgery, with the wound closed using the aforementioned materials. Histopathology revealed cellular ependymoma, and the patient received radiotherapy. Despite undergoing complete resection, he developed a foreign body reaction as a result of the sutures used. [Extracted from the article]

Despite the treatment, the wound continued to progress suggesting lack of efficacy to amikacin and linezolid. She had multiple abdominal debridements, antibiotics adjustments and taper of unspecified immunosuppressant. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event In a case report, a 2-year-old girl was described who exhibited lack of efficacy during treatment with amikacin and linezolid for I Mycobacterium abscessus i infection. [Extracted from the article]

Thus, antifungal therapy with anidulafungin and amphotericin B liposomal were started for invasive mucormycosis [ I dosages and routes not stated i ]. On the same day, her right axilla was found to have progressive necrosis that led to a forequarter amputation with right chest wall debridement. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event In a case report of 4 patients, a 42-year-old woman was described, who exhibited lack of efficacy during treatment with amphotericin B liposomal and anidulafungin for invasive mucormycosis. [Extracted from the article]

After the aortotomy, a tumour from the left coronary leaflet and an inflamed aortic valve annulus were removed, and an artificial aortic valve was implanted. Laboratory screening detected I Candida albicans i susceptible to fluconazole and voriconazole from microbiological workup of aortic valve vegetation and elevated inflammatory markers. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 37-year-old woman exhibited lack of efficacy during treatment with fluconazole for native aortic valve Candida albicans endocarditis [ I route and dosage not stated i ]. [Extracted from the article]

At 7 months after the revision surgery, the soft tissue was healed completely at the tooth no. 19 site and bone loss persisted. Postoperatively, he received oral amoxicillin/clavulanic acid 875mg twice a day [Augmentin; GlaxoSmithKline], chlorhexidine mouth rinse and ibuprofen as needed. Eight weeks following initial extraction, he was admitted and underwent revision surgery of ridge preservation at tooth no. 19. [Extracted from the article]

A CT scan showed signs of gastric perforation and an urgent exploratory laparotomy was performed. The site of perforation was suspected to be the posterior gastric wall, but it could not be reached surgically because of the presence of the frozen abdomen syndrome. A CT scan showed a 10cm extra-fascial abscess at the level of the right iliac fossa with extension to the right groin though the inguinal canal. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event In a study, 5 women aged 45-75 years were described, who developed gastric perforation (1 patient), voluminous pelvic abscess and extrafascial abscess (1 patient), bowel perforation, ureteral fistula, complete wound's dehiscence, floating thrombus in the left ventricle (LV) and TakoTsubo syndrome (1 patient), colonic-ureteric fistula (1 patient), and arterial-colic fistula (1 patient) during treatment with bevacizumab, carboplatin, gemcitabine or paclitaxel for ovarian carcinoma [ I routes, dosages and duration of treatments to reactions onset not stated i ]. [Extracted from the article]

Self-injected overdose of dalteparin sodium was considered as risk factor for elevated activated partial thromboplastin time, left arm anterior compartment syndrome and surgical site bleeding. His peak low molecular weight heparin anti-Xa level was 8.94 U/mL (at about 3h after overdose) and aPTT was increased to >150s (at about 3h after overdose). [Extracted from the article]

Three months after the surgery, she developed suspected localised cellulitis from a possible skin suture abscess. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 58-year-old woman developed allergic reaction during treatment with cotrimoxazole for cellulitis at the surgical site. Post-completion of the antibiotic therapy, the incision area was closed with no drainage and redness [ I reaction outcome not stated i ]. [Extracted from the article]

The patients were scheduled for sleeve gastrectomy (5 patients) and gastric bypass (3 patients) at SJHH, Canada. In the patient with surgical site bleeding after additional dose of heparin, heparin was withheld, and the patient was managed using dalteparin sodium and later warfarin. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A single-center retrospective cohort study of 389 patients weighing 160kg or more, who underwent bariatric surgery at St. Joseph's Healthcare Hamilton (SJHH), Canada, between September 2015 and September 2019, described eight patients [ I ages and sexes not stated i ], who developed coffee ground emesis, intra-abdominal haemorrhage, surgical site bleeding, haematoma in the hernia sac, haematoma at the lap incision site, vaginal bleeding or gastrointestinal bleeding during prophylactic anticoagulation treatment with heparin or tinzaparin sodium for prevention of venous thromboembolism [ I not all durations of treatments to reactions onsets and outcomes stated i ]. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event In a study of patients recruited between January 2010 and September 2019, 15 patients (10 women and 5 men) aged 29-76 years were described, who developed DRESS syndrome during treatment with vancomycin for various infections [ I dosages, routes, duration of treatments to reaction onsets and outcomes not stated i ]. The patients had culture-negative soft-tissue infection with underlying rib osteomyelitis (1 patient), methicillin-resistant I Staphylococcus aureus i (MRSA) right chest phlegmon, deep soft-tissue infection, underlying osteomyelitis of second rib with fracture (1 patient), MRSA and I Escherichia coli i bacteraemia with chest infiltrate (1 patient), MRSA wound infection leading to hip prosthesis removal and placement of vancomycin spacer (1 patient), complex ocular infection (1 patient), soft tissue cellulitis (1 patient), MRSA wound infection (1 patient), I Enterococcus faecalis i pyelonephritis (1 patient), ventriculitis-empirical culture negative (2 patients), post-cardiac surgery wound infection-culture negative (1 patient), I Enterococcus i species bacteraemia and endocarditis (1 patient), MRSA osteomyelitis (1 patient), traumatic arm injury and possible osteomyelitis (1 patient), skin and soft tissue infection-methicillin-susceptible I Staphylococcus aureus i (1 patient). Seven of the 15 patients were treated with prednisone (6 patients) and unspecified high-dose steroids (1 patient). [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event In a retrospective study of 65 patients who had undergone endothermal venous ablation (radiofrequency ablation or endovenous laser ablation) of the great saphenous vein or small saphenous vein to treat symptomatic venous reflux between April 2011 and May 2013, a patient [ I age and sex not stated i ] was described, who developed bleeding from the phlebectomy site during anticoagulation therapy with warfarin. The patient, who had been receiving anticoagulation therapy with warfarin [Coumadin; I route and dosage not stated i ] for long-term, underwent endothermal venous ablation to treat symptomatic venous reflux. Radiofrequency and laser vein ablation for patients receiving warfarin anticoagulation is safe, effective, and durable. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 17-year-old girl developed I Clostridium difficile i enteritis during treatment with ceftriaxone, ceftazidime and vancomycin. The girl was commenced on parenteral empiric antibiotic treatment with ceftriaxone 1 g/day, along with IV vancomycin 1 g/daily. Thereafter, she received parenteral antibiotic treatment with IV ceftazidime 1g three times daily and IV vancomycin 1 g/daily. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 40-year-old man exhibited lack of efficacy following treatment with paracetamol for fever. However, his infection and resulting fever had not responded to the treatment. Antibiotic susceptibility test revealed that the isolate I Chromobacterium violaceum i was resistant to cefixime and various other antibiotics. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 54-year-old man developed surgical site bleeding during anticoagulant therapy with clopidogrel. His medical history was significant for cardiac stent placement, for which he had been receiving anticoagulant therapy with clopidogrel [ I dosage and route not stated i ]. However, on post-operative day 6, surgical site bleeding was found to be persistent and he developed orthostasis. [Extracted from the article]