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A 26-year-old man developed hypogammaglobulinaemia while being treated with ocrelizumab for multiple sclerosis. He was referred to a tertiary center due to acute osteomyelitis of the left hip, likely linked to a complicated urinary tract infection. Despite treatment with antibiotics, his symptoms persisted and cultures came back negative. After further investigations, it was suggested that ocrelizumab may have contributed to the rare infection by depleting B-cells and causing hypogammaglobulinemia. Ocrelizumab was discontinued and immunoglobulin therapy was initiated. [Extracted from the article]

A 55-year-old woman experienced anaphylactic shock after receiving polyvalent snake antivenin for a snakebite. She had been bitten on the left hand while working on a farm and developed blisters and skin lesions. The antivenin was administered as an IV infusion over 3 hours, but her blood pressure dropped and oxygen saturation decreased. She was diagnosed with life-threatening anaphylactic shock and received treatment for anaphylaxis. After further treatment, including wound debridement and skin grafting, she was discharged from the hospital after 8 weeks. [Extracted from the article]

Author InformationAn event is serious (based on the ICH definition) when the patient outcome is:• * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important eventIn a retrospective study involving 10 patients, who received continuous local antibiotic perfusion (CLAP) between August 2018 and September 2019, an 81-year-old patient [sex not stated] was described, who developed acute kidney injury (AKI) during treatment with gentamicin for methicillin-susceptible Staphylococcus aureus infection. [Extracted from the article]

Conventional radiography revealed a bone-condensation reaction with a periosteal reaction close to the ulcers; CT scan showed subcutaneous fat tissues and muscle compartments filled with nodules, where severe muscle oedema was evident. The left leg ulcer worsened after use of different wound dressings and negative pressure wound therapy; however, it was healed by venous compression. Therefore, the patient's right leg ulcer was treated with negative pressure wound therapy with resolution. [Extracted from the article]

Patient 9: A 65-year-old woman with closed 34-C1 patella fracture, received preoperatively antibiotic prophylaxis treatment with cefazolin 2g once and underwent open reduction and internal fixation. Patient 8: A 41-year-old man with open 34-C1 patella fracture, received preoperatively antibiotic prophylaxis treatment with cefazolin 2g once and underwent open reduction and internal fixation. Later, he received unspecified antimicrobial therapy, irrigation, implant retention, underwent debridement and negative-pressure wound therapy for soft-tissue. [Extracted from the article]

These findings lead to the diagnosis of wound infections [deep sternal wound infection]. Results confirmed CMV infection. The mNGS result revealed cytomegalovirus (CMV) and Staphylococcus aureus infections. [Extracted from the article]

Subsequently, he developed tension pneumothorax following treatment with methylprednisolone-sodium-succinate for disseminated intravascular coagulation and an off label dexamethasone for COVID-19 [ I not all exact routes stated; duration of treatmentd to reaction onset not stated i ]. Chest CT demonstrated a large right pneumothorax due to collapsed cysts with mediastinal shift, strongly suggestive of tension pneumothorax. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 73-year-old man exhibited lack of efficacy during treatment with remdesivir and off-label casirivimab/imdevimab, dexamethasone and tocilizumab for COVID-19. [Extracted from the article]

Subsequently, she underwent ray amputation of the left ring finger. Case 2: A 56-year-old woman, who had poorly controlled diabetes mellitus, congestive cardiac failure, and a history of right transtibial amputation and left third toe ray amputation, presented with left palm swelling for four days. She also underwent debridement of the left hand and ray amputation of left middle finger. [Extracted from the article]

A dermal template collagen dressing was applied, and covered by a nonadherent, perforated polyamide net coated with silicone dressing and a border foam dressing. He underwent a gentle debridement of wound with a microfiber debrider pad, and a dermal template collagen dressing was placed and it was covered by portable single-use negative pressure wound therapy. [Extracted from the article]

Histopathological examination, cultures as well as genomic sequencing of all specimens, including pleural fluid, uniformly showed I A. fumigatus i infection [ I duration of treatments to reactions onset not stated i ]. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 66-year-old man developed I Aspergillus fumigatus (A. fumigatus) i infection while receiving antibiotic treatment with linezolid, meropenem, tigecycline and vancomycin. The complete thoracic cavity was irrigated for 40 minutes with each drug, and an open chest treatment with NPWT between the re-explorations. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 60-year-old man developed gas gangrene of the leg by I Clostridium perfringens i following administration of epinephrine for bee sting allergy. Epinephrine auto-injection after allergic reaction leading to gas gangrene of the leg. [Extracted from the article]

Based on the clinical presentation and laboratory findings, severe rhabdomyolysis was considered, which lead to the development of multiorgan dysfunction including liver dysfunction and acute kidney injury secondary to acute tubular necrosis complicated with severe hyperkalaemia and severe hyperphosphataemia. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event * Drug overdose A 45-year-old woman developed drug toxicity in the form of rhabdomyolysis, compartment syndrome, hearing loss, altered mental status, tachycardia, passing out, lethargy, confusion, pneumonia, colitis, hyperkalaemia, hyperphosphataemia, acute tubular necrosis, multiorgan dysfunction, acute kidney injury, liver dysfunction, cardiomyopathy and heart failure following abuse and overdose of mitragyna speciose for pain management. Two months prior to her admission, she underwent breast reconstruction surgery and suffered a burn injury from a heating pad used for postoperative pain. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 51-year-old man developed atrial fibrillation (AF) following treatment with isoprenaline during radiofrequency catheter ablation (RFCA) procedure. Pre-operative echocardiogram demonstrated normal LV ejection fraction (LVEF) in AF rhythm, and there were no signs of coronary artery disease (CAD). [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event In a retrospective study of 11 patients, who were diagnosed with Nicolau syndrome (NS) between December 2013 and January 2018, 11 patients including 9 women and 2 men aged 24-78 years were described, who developed NS during treatment with diclofenac or unspecified NSAID for migraine or pain or during antibiotic treatment with ampicillin/sulbactam or ceftriaxone [ I dosages and durations of treatments to reactions onsets not stated; not all outcomes stated i ]. The patients had been receiving treatment with IM diclofenac [diclofenac sodium] injection (n=8) for pain only (n=7) and migraine and pain (n=1) and antibiotic treatment with IM ceftriaxone injection (n=2) and IM ampicillin/sulbactam injection (n=1) in the right gluteal region (n=7), left gluteal region (n=3) and bilateral anterior thighs (n=1). One patient had received IM diclofenac injection at home, while 1 patient had received IM diclofenac injection at an external clinic. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event * Drug overdose An 18-year-old woman developed loss of consciousness following an overdose of metformin, vildagliptin, dapagliflozin and glimepiride, which were prescribed for her grandmother in an attempt of suicide, and multiple limb compartment syndrome secondary to capillary leak syndrome (CLS) following an overdose of metformin and vildagliptin. Based on these findings and clinical presentation, it was concluded an overdose of metformin, vildagliptin, dapagliflozin and glimepiride, which were prescribed for her grandmother in an attempt of suicide resulted in loss of consciousness, overdose of metformin and vildagliptin caused CLS, which resulted in multiple limb compartment syndrome, and overdose of metformin resulted in lactic acidosis. Multiple limb compartment syndrome as a manifestation of capillary leak syndrome secondary to metformin and dipeptidyl peptidase IV inhibitor overdose: A case report. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 44-year-old man experienced masking of symptoms of underlying gut necrosis and perforation during treatment with methylprednisolone and prednisone for adult-onset immunoglobulin A vasculitis (IgAV). Based on the clinical picture, it was noted that the delay in diagnosis of gut necrosis and bowel perforation was possibly due to the masking of their symptoms with methylprednisolone and prednisone. Case of Gut Necrosis in Adult-Onset Immunoglobulin A Vasculitis (Henoch-Schonlein Purpura). [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A patient [ I age and sex not stated i ] acquired resistance during treatment with ciprofloxacin for I Aeromonas veronii i infection. The patient started receiving Leech therapy with ciprofloxacin 500mg [ I route not stated i ] twice daily as prophylactic antibiotic treatment. The Leech therapy and ciprofloxacin prophylactic treatment was stopped on day 7. [Extracted from the article]

During this whole treatment, his kidney graft became better and pancreas graft function was good, and at the end, the graft function returned to the proper condition. Severe infection with skin necrosis of the leg after simultaneous pancreas and kidney transplantation. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 66-year-old man developed interstitial pneumonia during treatment with amiodarone for dilated cardiomyopathy. Five months after the discharge, he developed amiodarone-induced interstitial pneumonia [ I duration of treatment to reaction onset not stated i ]. New treatment for driveline infection following implantation of a ventricular assist device. [Extracted from the article]

A 74-year-old man experienced delayed healing of recurrent abdominal wall while receiving the treatment with bevacizumab for recurrent tumour in the abdominal wall. Therefore, he received antibacterial treatment and underwent negative pressure wound therapy. 1 Maeda H, et al. [Efficacy of Negative Pressure Wound Therapy for Post-Operative Wound Dehiscence after Resection of a Metastatic AbdominalWal lTumor from Cecal Cancer during Chemotherapy with Bevacizumab]. [Extracted from the article]

After 2 months, an arm X-ray showed significant soft tissue calcification, thereby confirming calcinosis cutis. B Author comment: b I "Extravasation of calcium solutions can lead to severe lesions, with significant edema reported in 48% of cases, erythema in 65%,...and secondary necrosis". "The main characteristic related to the extravasation of calcium solutions is the presence of calcium deposits, which can be observed as papules, nodules, or whitish subcutaneous deposits...subcutaneous calcifications (calcinosis cutis)". i. [Extracted from the article]

A 38-year-old man exhibited lack of efficacy during treatment with norepinephrine for haemodynamic instability in Following emergency median sternotomy, surgical debridement of necrotic tissue, and de novo vacuum-sealing drainage, his overall clinical condition improved. B Author comment: b I "Because of his hemodynamic instability, we administered norepinephrine, but increasing the dosage from 0.2 mg/hr to 1 mg/hr over the next 48 hr was unsuccessful in reverting his poor systemic vascular resistance of <=700 dyn/s/cm5." i. [Extracted from the article]

In a retrospective study of 25 paediatric patients, treated from January 2011 to January 2016, a patient[1] [ I age and sex not stated i ] was described, who developed wound dehiscence during immunosuppressive treatment with tacrolimus, methylprednisolone, prednisolone and unspecified steroid therapy. The patient developed minor wound dehiscence during the hospital course [ I time to reaction onset not stated i ]. The wound healing of the patient was achieved with continuous (curative) negative pressure wound therapy alone, without any surgical procedures. [Extracted from the article]