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A retrospective study conducted at Cangshan Hospital in China examined the efficacy of fluorouracil, folinic-acid, cisplatin, and oxaliplatin in the treatment of metastatic gastric cancer. The study involved 286 patients, and two patients with abdominal metastases underwent lesion resection surgery followed by intraperitoneal chemotherapy. Both patients received cisplatin and fluorouracil through intraperitoneal infusion, as well as cyclical treatment with oxaliplatin, folinic-acid, and fluorouracil through intravenous infusion. Despite the treatment, one patient developed ovarian metastases and the other had hepatic metastases, indicating a lack of efficacy of the drugs in both cases. [Extracted from the article]

Author InformationAn event is serious (based on the ICH definition) when the patient outcome is:• * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important eventIn a study, six women aged 54-72 years were described, who developed myalgia, general weakness, muscle spasms, fatigue, insomnia, arthralgia or musculoskeletal pain during treatment with doxorubicin, cyclophosphamide, paclitaxel or anastrozole for breast carcinoma [routes not stated; not all dosages, durations of treatments to reactions onsets and outcomes stated]. [Extracted from the article]

Author InformationAn event is serious (based on the ICH definition) when the patient outcome is:• * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important eventA retrospective observational study conducted at the Northwest General Hospital & Research Centre between 2013 to 2019 involving 153 patients with hyperthyroidism, described two adult patients [sexes and exact ages not stated], who developed hypothyroidism following administration of iodine-radioactive for hyperthyroidism [routes, dosages and outcomes not stated]. [Extracted from the article]

A retrospective study involving 1258 patients who received fondaparinux-sodium after orthopedic or trauma surgery found a lack of efficacy in one patient. The patient, who underwent femoral surgery, received a daily injection of 2.5 mg of fondaparinux-sodium but still developed venous thromboembolism (VTE). This case suggests that fondaparinux-sodium may not be effective as an anticoagulant therapy in some individuals. [Extracted from the article]

She had no medical history of diabetes but had a family history of diabetes. New-Onset Fulminant Type 1 Diabetes Following SARS-CoV-2 Protein Subunit Vaccine: A Case Report and Literature Review. Six days ago, she received fourth dose of ZF2001 [Zifivax/ZF2001, protein subunit vaccine; I dose and route not stated i ]. [Extracted from the article]

On day 5 of furosemide and chlorothiazide initiation, his laboratory tests revealed a bicarbonate level at 39 mmol/L, potassium at 3.9 mmol/L and creatinine at 2.69 mg/dL. Despite of unspecified potassium-sparing-diuretics and acetazolamide, on day 7 of chlorothiazide and furosemide and on day 1 of acetazolamide and potassium-sparing-diuretics initiation, his bicarbonate level increased to 44 mmol/L (lack of efficacy) and underwent a renal replacement therapy. [Extracted from the article]

A 54-year-old woman (Case 1): The woman had hypertension, hyperlipidaemia, diabetes mellitus and coronary heart disease (CHD). She also had bronchial asthma, and she started receiving inappropriate metoprolol treatment for 3 months following prescription error (medication error). She had medical history significant for bronchial asthma, and she started receiving inappropriate metoprolol treatment for 9 months following prescription error (medication error). [Extracted from the article]