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An 88-year-old woman experienced anaphylaxis while taking pregabalin for neuropathic leg pain. She had a history of congestive heart failure and neuropathic leg pain, and her symptoms included lip swelling, shortness of breath, and wheezing. After discontinuing pregabalin and receiving treatment with various medications, her symptoms resolved, and follow-up showed no recurrence of anaphylaxis. [Extracted from the article]

A 62-year-old woman developed myositis ossificans while being treated with romosozumab for bone mass increases. She had a medical history of hyperthyroidism, hypertension, and dyslipidaemia, and had undergone lumbar surgery in the past. After experiencing persistent pain post-surgery, she received romosozumab and later developed myositis ossificans, which was successfully treated with etidronic acid. The woman showed improvement with treatment and did not experience a recurrence of the condition. [Extracted from the article]

An 81-year-old man developed a Nocardia Farcinica brain abscess while being treated for rheumatoid arthritis and vasculitis with prednisone, hydroxychloroquine, and methotrexate. He presented with right leg pain and a thigh abscess, with subsequent MRI revealing a brain lesion. Treatment with cotrimoxazole and imipenem led to significant improvement, and the man remained neurologically asymptomatic throughout the recovery process. [Extracted from the article]

A 66-year-old woman experienced bilateral lumbar pedicle fracture while being treated with minodronic-acid for osteoporosis. She presented with gait disturbance and lower back pain radiating to both legs. Despite undergoing nerve root block and physical therapy, her condition did not improve. The woman had a history of osteoporosis and had been taking minodronic-acid for six years. After undergoing surgery, her leg pain improved and a CT scan two years later showed evidence of bony fusion at the fracture sites. [Extracted from the article]

A 12-year-old boy developed manic episodes while being treated with adalimumab for juvenile idiopathic arthritis. Prior to starting adalimumab, the boy had a history of mood disorder and his condition had worsened over the past month. After receiving three adalimumab injections, he experienced increased emotional instability, including low mood, self-harm, and suicidal ideation. These symptoms were found to be temporally associated with the administration of adalimumab. The boy was hospitalized and treated with electroconvulsive therapy, which improved his symptoms. His adalimumab therapy was stopped and he did not experience a recurrence of manic symptoms during follow-up. [Extracted from the article]

A case report published in Reactions Weekly discusses a 35-year-old pregnant woman who experienced lack of efficacy while being treated with gabapentin and paracetamol for lumbar radiculopathy. The woman, who had a history of lumbar radiculopathy and previous surgeries, presented with severe pain that interfered with her daily activities. After failing to respond to paracetamol and gabapentin, she received an unspecified epidural steroid injection for her condition. The outcome of the pregnancy was not stated in the report. [Extracted from the article]

A male patient with multiple medical conditions, including chronic low back pain, was treated with various medications such as gabapentin, topiramate, duloxetine, paracetamol, hydromorphone, hydrocodone/paracetamol, and unspecified nonsteroidal anti-inflammatories. However, these medications were found to be ineffective in relieving his pain. The patient later underwent spinal cord stimulation, which initially provided significant pain relief but had to be explanted due to unwanted abdominal stimulations. Despite difficulties with reimplantation, the patient ultimately experienced more than 50% relief of his pain and improved mobility. [Extracted from the article]

A 19-year-old woman with a history of Steven-Johnson syndrome was treated for henoch schonlen purpura (HSP) with azithromycin and loratadine. However, she experienced a lack of efficacy with these medications, as she continued to have symptoms such as sore throat, itching, and pain in her legs. Her treatment was adjusted by increasing the dosage of methylprednisolone and adding chlorpheniramine-maleate, which resulted in a reduction of her symptoms. This case report highlights the need for individualized treatment approaches for patients with HSP and emphasizes the importance of monitoring medication efficacy. [Extracted from the article]

In a case series of 5 patients, two young girls experienced adverse reactions during treatment with antibiotics for group A streptococcus (GAS). A 3-year-old girl developed a rash while receiving ceftriaxone, which was discontinued and she recovered without complications. A 5-year-old girl exhibited a lack of efficacy while receiving cefotaxime, clindamycin, and linezolid, and unfortunately, she died due to irreversible brain injury. These cases highlight the potential risks and limitations of antibacterial therapy for GAS infections. [Extracted from the article]

A 62-year-old man experienced anaphylaxis while being treated with aspirin/hydrotalcite as an antacid therapy. He presented to the emergency department with back pain, leg pain, and mild difficulty breathing. The patient had a history of anaphylaxis to a contrast dye in the past. After experiencing symptoms of low blood pressure and respiratory issues following the ingestion of aspirin/hydrotalcite, he was diagnosed with anaphylaxis. The man was treated with epinephrine, chlorphenamine, and fluid resuscitation, and his symptoms eventually resolved. [Extracted from the article]

A 62-year-old man experienced anaphylaxis while being treated with aspirin/hydrotalcite as an antacid therapy. He presented to the emergency department with back pain, leg pain, and mild difficulty breathing. The patient had a history of anaphylaxis to a contrast dye in the past. After experiencing symptoms of low blood pressure and respiratory issues following the ingestion of aspirin/hydrotalcite, he was diagnosed with anaphylaxis. The man was treated with epinephrine, chlorphenamine, and fluid resuscitation, and his symptoms eventually resolved. [Extracted from the article]

A 39-year-old woman with a history of hereditary thrombophilia and deep vein thrombosis (DVT) experienced lack of efficacy with methadone, hydromorphone, and morphine for intractable leg pain. She was then treated with ketamine, which provided good pain control but also caused anxiety and mild dissociation. The patient's symptoms were managed by an interdisciplinary team using expressive arts therapy and massage therapy. This case highlights the potential lack of efficacy and side effects associated with ketamine and opioid analgesics in the treatment of intractable leg pain. [Extracted from the article]

This article discusses the use of erdafitinib, a medication used for the treatment of certain types of brain tumors, in three pediatric patients. The first patient, a 10-year-old girl, did not respond to the medication and experienced side effects such as leg pain, dry skin, and abdominal pain. The second patient, a 12-year-old boy, also did not respond to the medication and had intra-tumoral bleeding. The third patient, a 13-year-old boy, initially showed a reduction in tumor size but experienced side effects such as pain in the lower extremities and diarrhea. Overall, the use of erdafitinib did not result in a therapeutic response in these patients and was associated with various side effects. [Extracted from the article]

A 59-year-old man developed disseminated cryptococcosis while undergoing immunosuppressive therapy with tacrolimus, prednisolone, and mycophenolate mofetil. He presented with fever, leg pain, swelling, and redness. The man was treated with antibiotics and underwent wound debridement. The diagnosis of disseminated cryptococcosis was confirmed through pus examination and culture. He was treated with antifungal medication and his immunosuppressive therapy was gradually tapered. After appropriate treatment, his wound healing improved and his renal functions also improved. [Extracted from the article]

A 33-year-old woman with pelvic squamous cell carcinoma (SCC) of unknown primary experienced drug ineffectiveness with carboplatin and paclitaxel. She initially received chemoradiotherapy with cisplatin, which showed slight improvement, but the size of the pelvic mass increased after four months. She then started second-line therapy with paclitaxel and carboplatin, but her tumor markers rose and she experienced increased leg pain. The therapy was discontinued and she was treated with nivolumab as a third-line therapy, which initially improved her condition but later deteriorated. Nivolumab was subsequently discontinued. [Extracted from the article]

A retrospective observational study examined 82 patients who were treated with pregabalin and mirogabalin for peripheral neuropathic leg pain. Four patients experienced adverse events such as oedema, dizziness, and somnolence while taking pregabalin. One patient also reported lack of efficacy with pregabalin. The patients were then switched to mirogabalin, but they continued to experience adverse events. The study did not provide specific details about dosages, routes, duration of treatment, or outcomes. [Extracted from the article]

A case report published in Reactions Weekly describes a 13-year-old boy with McCune-Albright syndrome (MAS) who exhibited lack of efficacy during treatment with alfacalcidol and monosodium-phosphate. The boy had previously experienced fractures and had been receiving various medications. Despite ongoing treatment, his bone biochemistry remained abnormal and he complained of ongoing leg pains. As a result, alfacalcidol and monosodium-phosphate were discontinued and burosumab was started, which led to normalization of his bone biochemistry without any adverse effects. [Extracted from the article]

An adult woman experienced a lack of efficacy during treatment with gabapentin, duloxetine, and unspecified opioid analgesics for pain. She initially presented with symptoms of acute cystitis and was treated for a urinary tract infection. However, she returned to the emergency room with worsening abdominal pain, bilateral hip pain, bilateral leg pain, allodynia, dizziness, and diffuse hyperesthesia. She was eventually diagnosed with eosinophilic meningitis and Angiostrongylus cantonensis infection. Despite treatment with gabapentin, duloxetine, and opioid analgesics, her neuropathic pain remained uncontrolled. Lidocaine was eventually administered, leading to improvement. [Extracted from the article]

His treatment course was complicated as he developed leucopenia due to cyclophosphamide and leg pain and myopathy due to methylprednisolone. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 73-year-old man developed leucopenia, myopathy or leg pain during treatment with cyclophosphamide or methylprednisolone for acquired hemophilia A (AHA) [ I routes, duration of treatments to reactions onset and outcomes not stated i ]. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 55-year-old man developed knotty periarteritis secondary to rebound effect following withdrawal of apremilast administered for treatment of psoriasis The man, who had a history of psoriasis, presented to the emergency room with leg and testicular pain. Para-clinical examination showed hyperleukocytosis and inflammatory syndrome. The man was commenced on corticosteroid therapy, which relieved symptoms and controlled biological eosinophilia and inflammatory syndrome. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 37-year-old woman developed atypical femur fracture during treatment with denosumab for low bone density. Subsequently, an MRI revealed periosteal thickening consistent with a femur stress fracture. Due to stress fracture and continued discomfort, she was diagnosed with denosumab-related atypical femur fracture [ I duration of treatment to reaction onset not stated i ]. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 32-year-old woman developed cutaneous small vessel vasculitis following off-label use of glycerol/hyetellose/purified-water as contrast medium during hysterosalpingo-foam sonography. Reference 1 Ludwin A, Ludwin I, Szczeklik W, Martins W. P. Cutaneous small-vessel vasculitis following hysterosalpingo-foam sonography (HyFoSy). [Extracted from the article]

He also developed alemtuzumab-related lymphopenia; further, he developed elevated ALP levels during treatment with voriconazole and leg pain during treatment with posaconazole for the disseminated I Rhinocladiella i infection [ I not all routes, dosages, times to reactions onsets and outcomes stated i ]. On 21 October 2014 (day 0), a contrast-enhanced CT scan revealed a 2.5cm ring-enhancing lesion with a low-attenuation centre and a large volume of surrounding vasogenic oedema in his left posterior frontal lobe, which was thought to represent an abscess. However, even after about 2 months of posaconazole, there was a limited effect on the fungus: repeat outpatient head CT imaging on day 41 showed an enlarged ring-enhancing mass lesion maximal diameter of 2.9cm. Therefore, excision surgery was scheduled. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 31-year-old woman developed cellular non-specific interstitial pneumonia (NSIP) and acute pulmonary histoplasmosis during treatment with prednisone for dermatomyositis. The woman, who had a history of dermatomyositis, was receiving chronic prednisone therapy [ I dosage and route not stated i ] and presented with a complaint of nausea and the leg pain. Acute pulmonary histoplasmosis and NSIP were considered, which were attirbuted to prednisone immunosuppression [ I duration of treatment to reactions onsets not stated i ]. [Extracted from the article]

A 62-year-old woman developed acute attack of atrial fibrillation (AF) during treatment with etoricoxib for leg pain. Later, IV amiodarone was replaced by oral amiodarone. B Author comment: b I "Here we report a female patient who presented to the emergency department with an acute attack of AF: possibly a drug-induced adverse effect following the history of intake of etoricoxib for 2 days for musculoskeletal pain.". [Extracted from the article]

A 14-year-old boy developed granulomatosis with polyangiitis (GPA) during treatment with isotretinoin for acne. The boy, who had multiple treatment resistant acne, eventually started receiving treatment with isotretinoin [ I route and dosage not stated i ]. However, approximately 6 weeks later, he developed non-purulent conjunctivitis, fatigue, retro-sternal chest pain with dyspnoea, bilateral lower extremity muscle aches and joint pains. [Extracted from the article]

A 7-year-old boy developed acute hypervitaminosis-A and pseudotumor cerebri following the accidental ingestion of retinol in an overdose. A provisional diagnosis of hypervitaminosis-A and intracranial hypertension (pseudotumor cerebri) was established. [Extracted from the article]

A 49-year-old woman developed type IV hypersensitivity reaction following treatment with enbucrilate for venous insufficiency. On the thirteenth post-operative day (POD), she presented with leg pain and redness, which were presumed to be either an allergic reaction or a phlebitis. Post excision, she had excision related swelling of the left leg and pain. [Extracted from the article]

In a case series, three women were described, of whom a 58-year-old woman developed atypical stress fracture of the femur during treatment with risedronic acid and methylprednisolone, a 79-year-old woman developed atypical stress fracture of the femur during treatment with denosumab and an approximately 72-year-old woman developed atypical femoral fracture (AFF) during treatment with alendronic acid [ I not all dosages and routes stated i ]. In March 2014 the evolving and disabling pain was attributed to a non-union of the left femur stress fracture; therapy with denosumab was considered to be contributory to the fracture [ I time to reaction onset not stated i ]. [Extracted from the article]

The article presents a case study of 31-year-old woman having fatal multiple intraventricular haemorrhages, rupture of recurrent internal carotid artery aneurysm.