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A 52-year-old man experienced lack of efficacy while being treated for sepsis with amoxicillin/clavulanic-acid, gentamicin, meropenem, and clindamycin after being bitten by a dog. Despite initial treatment, the infection progressed, leading to his death on the eleventh day due to severe sepsis. The patient's condition deteriorated despite supportive therapy, including renal replacement therapy, and extensive necrosis of the extremities. Ultimately, supportive therapy was discontinued in consultation with his family. [Extracted from the article]

A 43-year-old man experienced myocardial infarction with nonobstructive coronaries after receiving a rabies vaccine for postexposure prophylaxis. He presented with chest pain and had received aspirin, clopidogrel, and atorvastatin prior to hospitalization. The ECG showed signs of acute inferior wall myocardial infarction, and blood tests revealed elevated WBC count and positive troponin-I. Treatment with medications and supportive measures led to improvement, and he was discharged on a regimen of aspirin, clopidogrel, and statins. [Extracted from the article]

A 10-year-old boy developed thrombotic microangiopathy after receiving a rabies vaccine. He also experienced a lack of efficacy with treatment using methylprednisolone, prednisone, and mycophenolate-mofetil. The boy presented with symptoms of haemolysis following a dog bite and had a history of a previous COVID-19 infection. Despite treatment, his condition did not improve until he underwent plasma exchange, which normalized his blood picture and kidney functions. A renal biopsy confirmed the diagnosis of thrombotic microangiopathy secondary to the rabies vaccine. [Extracted from the article]

A 65-year-old woman developed ptosis (drooping of the eyelid) while receiving treatment for a dog bite. She had been bitten by a dog and sought medical attention, receiving various treatments including rabies-immune-globulin. On the eighth day of treatment, her eyelid could not open, and she was admitted to the hospital. The woman was treated with antibiotics, steroids, and other medications, and her ptosis symptoms improved after ten days of treatment. [Extracted from the article]

An 84-year-old man with a history of arterial hypertension and a recent dog bite exhibited lack of efficacy during treatment with metronidazole and tetanus-immune-globulin for tetanus. He experienced symptoms such as dysarthria, dysphagia, and difficulty opening his mouth, leading to a diagnosis of tetanus. Despite receiving treatment, his condition worsened and he developed respiratory failure, requiring intubation and transfer to the ICU. After being sedated for 9 days, he eventually recovered and was weaned off mechanical ventilation. [Extracted from the article]

Three male patients, aged 17-57 years, experienced a lack of efficacy during treatment for rabies virus infection. In the first case, a 24-year-old man died despite receiving treatment with anti-rabies-monoclonal-antibody and favipiravir. Autopsy findings confirmed rabies virus infection. In the second case, a 17-year-old boy died despite treatment with amantadine, midazolam, and ketamine. Autopsy findings also confirmed rabies virus infection. In the third case, a 57-year-old man died despite treatment with amantadine, midazolam, ketamine, favipiravir, and anti-rabies-monoclonal-antibody. Autopsy findings once again confirmed rabies virus infection. [Extracted from the article]

This article discusses two cases of lack of efficacy and medication error in the treatment of rabies-immune-globulin and rabies-vaccine for immunization against rabies after dog bites. In the first case, a 12-year-old boy received the treatment but experienced symptoms of possible rabies and encephalopathy. Despite treatment, his condition deteriorated rapidly and he eventually died. In the second case, a 7-year-old boy received the treatment but also experienced symptoms of rabies and his condition deteriorated despite treatment, leading to his death. It was noted that he received a residual of rabies-immune-globulin that had been used for other animal bite victims, indicating a medication error. [Extracted from the article]

A 35-year-old man in Bhutan experienced a lack of efficacy following vaccination with a rabies vaccine, as well as treatment with rabies immune globulin, epinephrine, and norepinephrine. The man had been bitten by a dog and received post-exposure prophylaxis, but still developed rabies and encephalomyelitis. Despite receiving various treatments, including sedatives, antibiotics, antivirals, and supportive care, the man's condition worsened and he ultimately died from rabies. This case highlights the need for further research and improvement in the effectiveness of rabies prevention and treatment. [Extracted from the article]

Metagenomics next-generation sequencing findings led to a diagnosis of rabies. A new choice for human rabies diagnosis: A case report of metagenomics next-generation sequencing in diagnosis of human rabies. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 59-year-old man exhibited lack of efficacy during treatment with epinephrine and norepinephrine for hypotension and amantadine and ribavirin for rabies [ I not all routes and dosages stated i ]. [Extracted from the article]

Due to close temporal relationship between the development of acute onset pure motor neuropathy with the rabies vaccination, she was diagnosed with Guillain-Barre syndrome acute motor axonal neuropathy secondary to rabies vaccine. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 50-year-old woman developed Guillain-Barre syndrome acute motor axonal neuropathy following treatment with rabies vaccine. [Extracted from the article]

Thus, therapy was switched to ampicillin and ceftriaxone upon microbiological findings. An extensive therapy was commenced with initiation of mechanical ventilation; antibacterial treatment with meropenem 2g prolonged infusion four times in a day (qid), ampicillin 3g qid and clindamycin 900mg three times in a day (tid), methylprednisolone 500mg tid, 250mg twice in a day (bid), 250mg once daily (qd) and 125mg qd; unspecified vasopressors and continuous renal replacement therapy. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 61-year-old woman exhibited lack of efficacy during treatment with ceftriaxone, ampicillin, meropenem, clindamycin, methylprednisolone and unspecified vasopressors for Waterhouse-Friderichsen Syndrome (WFS), and plasma as a source of protein-C [ I routes not stated; not all dosages stated i ]. [Extracted from the article]

A 15-year-old boy developed optic neuritis following treatment with rabies vaccine. He had received four doses of chick embryo-derived IM rabies vaccine [ I dose not stated i ] every alternate day. Optic neuritis following anti-rabies vaccine. [Extracted from the article]

A 26-year-old man experienced vaccine failure following treatment with anti-rabies vaccine. Subsequently, he was diagnosed with rabies despite receiving anti-rabies vaccination. On day 6 of hospitalisation, repeat CSF antibody titre confirmed rabies. [Extracted from the article]

An ultrasound showed a massive soft tissue oedema with cellulite [ I duration of treatment to reactions onset not stated i ]. B Author comment: b I "This paper illustrates a case report of prolonged oedema and tissue swelling after irrigation of deep wounds with [octenidine/phenoxyethanol]." Subcutaneous tissue swelling and prolonged oedema: An unex-pected reaction after irrigation with Octenidini dihydrochloridum (Octenisept). [Extracted from the article]

In a report, 4 children (2 boys and 2 girls) aged 28 months-7 years were described, who developed allergic contact dermatitis following treatment with chlorhexidine. An epicutaneous patch testing with chlorhexidine [chlorhexidine digluconate] 0.5% in water was positive on day 2 and day 4. [Extracted from the article]

An abstract of the article "When horse serum meets dog bite" by A. Neumayr and others is presented.

An abstract of the article "Case of toxic epidermal necrolysis following a dog bite" by N. Linklater and others is presented.