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Soon after the outbreak of the COVID-19 pandemic, the world saw far-right leaders uniting to promote hydroxychloroquine despite controversial results. Why have some leaders actively promoted the drug since then, contradicting recommendations made by their own government's health authorities? Our argument is twofold. First, hydroxychloroquine has been an integral tool of medical populist performance in the context of the COVID-19 pandemic. We adopt Lasco & Curato's (2018) definition of medical populism as a political style based on performances of public health crises that pit 'the people' against 'the establishment' using alternative knowledge claims to cast doubt on the credibility of doctors, scientists, and technocrats. Second, rather than being an individual endeavor, medical populism addressing the coronavirus crisis has led populists to build an alt-science network. We define it as a loose movement of alleged truth-seekers who publicly advance scientific claims at a crossroads between partial evidence, pseudo-science, and conspiracy theories. It comprises scientists, businesspeople and celebrities united by their distrust of governments and mainstream science. In this article, we look at how the hydroxychloroquine alliance was formed, as well as its political and policy implications. To this end, we compare why and how Donald Trump and Jair Bolsonaro have appealed to medical populist performances when addressing the health crisis. By mobilizing the concepts of medical populism and alt-science, this paper aims to contribute to the scholarship on the relationship between populist politics and policy-making. [ABSTRACT FROM AUTHOR]