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Background Despite randomized control trials showing equivalent efficacy between single-fraction (SF) and multiple-fraction (MF) radiation therapy (RT) for bone metastases (BoM), considerable variation in fractionation exists. We compared patient-reported outcomes (PROs) following SF versus MF RT in a population-based cohort. Methods PROs were chosen to assess patients’ perception of pain, function, and symptom frustration. Total score was the sum of the 3 questions. Results 968 patients completed pre and post-RT PROs, 35% (335) had complicated BoM. Overall, there were no differences in total score improvement (79% vs. 83%; p = 0.13), nor for complicated BoM (77% vs. 84%; p = 0.12), SFRT and MFRT respectively. On multivariate analysis no differences in improvement in total score were observed between SFRT and MFRT overall (OR = 0.71; 95% CI 0.49–1.02; p = 0.06), nor for complicated BoM (OR = 0.74; 95% CI 0.39–1.39; p = 0.35). In the complicated BoM subset, pain complete response (CR) (19% vs. 33%; p = 0.01) and functional improvement occurred more commonly in the MFRT group (69% vs. 81%; p = 0.04). Conclusion Improvements in PROs for pain, function and symptom frustration were similar between SFRT and MFRT supporting the use of hypofractionated regimens. Using a simple, 3-question, telephone-based questionnaire to assess response to palliative RT is a feasible strategy to collect PROs. [ABSTRACT FROM AUTHOR]

• This study examined the stability of radiomic features from T2-weighted MRI of cervical cancer. • Three tests were applied: 1. test–retest; 2. diagnostic vs simulation MRI; and 3. inter-observer delineation. • The inter-observer cohort had the greatest number of reproducible features. • The diagnostic–simulation cohort had the fewest reproducible features. • Shape features were the most stable features in all three cohorts. The aims of this study are to evaluate the stability of radiomic features from T2-weighted MRI of cervical cancer in three ways: (1) repeatability via test–retest; (2) reproducibility between diagnostic MRI and simulation MRI; (3) reproducibility in inter-observer setting. This retrospective cohort study included FIGO stage IB-IVA cervical cancer patients treated with chemoradiation between 2005 and 2014. There were three cohorts of women corresponding to each aim of the study: (1) 8 women who underwent test–retest MRI; (2) 20 women who underwent MRI on different scanners (diagnostic and simulation MRI); (3) 34 women whose diagnostic MRIs were contoured by three observers. Radiomic features based on first-order statistics, shape features and texture features were extracted from the original, Laplacian of Gaussian (LoG)-filtered and wavelet-filtered images, for a total of 1761 features. Stability of radiomic features was assessed using intraclass correlation coefficient (ICC). The inter-observer cohort had the most reproducible features (95.2% with ICC ≥0.75) whereas the diagnostic–simulation cohort had the fewest (14.1% with ICC ≥0.75). Overall, 229 features had ICC ≥0.75 in all three tests. Shape features emerged as the most stable features in all cohorts. The diagnostic–simulation test resulted in the fewest reproducible features. Further research in MRI-based radiomics is required to validate the use of reproducible features in prognostic models. [ABSTRACT FROM AUTHOR]