1. Liver Steatosis: Concordance of MR Imaging and MR Spectroscopic Data with Histologic Grade
- Author
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Noworolski, Susan M, Lam, Maggie M, Merriman, Raphael B, Ferrell, Linda, and Qayyum, Aliya
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Chronic Liver Disease and Cirrhosis ,Liver Disease ,Digestive Diseases ,Biomedical Imaging ,Adult ,Biopsy ,Fatty Liver ,Female ,Humans ,Image Interpretation ,Computer-Assisted ,Linear Models ,Magnetic Resonance Imaging ,Magnetic Resonance Spectroscopy ,Male ,Middle Aged ,Retrospective Studies ,Severity of Illness Index ,Medical and Health Sciences ,Nuclear Medicine & Medical Imaging ,Clinical sciences - Abstract
PurposeTo determine if the concordance of magnetic resonance (MR) imaging and MR spectroscopic data with histologic measures of steatosis is affected by histologic magnification level, tissue heterogeneity, or assessment of tissue area versus that of hepatocytes.Materials and methodsThis study was institutional review board approved and HIPAA compliant. Written informed consent was obtained. In- and out-of-phase MR imaging and MR spectroscopic measures of steatosis were compared in 33 patients with nonalcoholic fatty liver disease and in 15 healthy volunteers. Concordance of MR imaging and MR spectroscopic data with histologic findings was assessed for (a) histologic examination at standard (×40 and ×100) versus high magnification (×200 and ×400), (b) heterogeneity and homogeneity of livers, and (c) percentage of tissue and hepatocytes that contained lipids. Evaluations included linear regression and Fisher exact tests.ResultsIn- and out-of-phase MR imaging and MR spectroscopic data were well correlated (R2=0.93) and generally concordant with histologic measures. Patients in whom MR fat fractions were higher than expected compared with steatosis grades at standard magnification histologic examination were upgraded significantly more often when high magnification was used than were the remaining patients (100% [10 of 10] vs 47% [7 of 15], P
- Published
- 2012