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At later times after the injection of selenium-75-selenium methionine to CBA mice the inhibition of migration of intravenously injected normal 51Cr lymphocytes to the lymph nodes and liver lasted for a long time. On the contrary, no changes in the normal lymphocyte migration within the animal body were observed after total-body gamma-irradiation with the dose of 4 Gy. The data obtained are indicative of the radiation-induced disturbance of the microenvironment factors, which provide migration of lymphocytes within the body, during the long-term exposure to radiation emitted by the incorporated source.

The administration to rats of radioactive preparations. 75Se- selenomethionine, 35S-methionine or sodium 75Se-selenite in the amounts creating the absorbed dose in the body of 0.5 Gy suppressed the delayed hypersensitivity reaction as was registered 1-12 months after the injection. The delayed hypersensitivity was tested in vitro by the method of inhibimacrophage spreding inhibition. The degree of suppression of the cellular immune response depended upon the type of the compound administered, of which the radionuclide was a component, and upon characteristics of radiation spectrum of the radionuclide.

In experiments on CBA mice it was shown that migration of 51Cr-labeled spleen lymphocytes, injected intravenously, to lymph nodes of intact recipients was suppressed 6-24 months after the administration of a radiopharmaceutic preparation of selenium-75-selenomethionine in a quantity forming the doses of 1 Gy and 1.5 Gy absorbed within the whole body and lymphoid organs, respectively. Migration of labeled lymphocytes to the liver, kidneys and lungs, as well as their retention in the circulating blood, were increased. As the result of the migration disorders the specific affinity of lymphocytes for peripheral lymphoid tissue decreased.