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Your search keyword '"Testa, N. G."' showing total 5 results
Start Over Author "Testa, N. G." Journal radiation research
5 results on '"Testa, N. G."'

5. The effect of low dose rate on recovery of hemopoietic and stromal progenitor cells in gamma-irradiated mouse bone marrow.

Author

Gallini R, Hendry JH, Molineux G, and Testa NG

Subjects
Animals, Bone Marrow radiation effects, Cell Survival, Cesium Radioisotopes, Cobalt Radioisotopes, Dose-Response Relationship, Radiation, Female, Gamma Rays, Granulocytes cytology, Granulocytes radiation effects, Macrophages cytology, Macrophages radiation effects, Male, Mice, Bone Marrow Cells, Hematopoietic Stem Cells radiation effects
Abstract

Long-term recovery of mouse hemopoietic stem cells (CFU-S and CFU-S per colony), granulocyte-macrophage precursor cells (GM-CFC), and stromal colony-forming units (CFU-F) after doses up to 12.5 Gy was almost complete by 1 year when the dose rate was reduced to 0.0005 Gy/min compared to incomplete recovery after doses up to only 6.5 Gy given at greater than 0.7 Gy/min. This sparing effect of dose rate on long-term hemopoietic recovery is in contrast to the generally reported lack of dependence on dose rate for acute survival of hemopoietic progenitors after doses up to 5 Gy. The present results are compatible with the hypothesis that good recovery of the stroma should be reflected in the long-term recovery of hemopoiesis.

Published
1988

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