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Your search keyword '"Monti Hughes, Andrea"' showing total 9 results
Start Over Author "Monti Hughes, Andrea" Journal radiation and environmental biophysics
9 results on '"Monti Hughes, Andrea"'

1. Electroporation optimizes the uptake of boron-10 by tumor for boron neutron capture therapy (BNCT) mediated by GB-10: a boron biodistribution study in the hamster cheek pouch oral cancer model

Author

Garabalino, Marcela A., Olaiz, Nahuel, Portu, Agustina, Saint Martin, Gisela, Thorp, Silvia I., Pozzi, Emiliano C. C., Curotto, Paula, Itoiz, María E., Monti Hughes, Andrea, Colombo, Lucas L., Nigg, David W., Trivillin, Verónica A., Marshall, Guillermo, and Schwint, Amanda E.

Published
2019
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5. Boron neutron capture therapy (BNCT) for liver metastasis in an experimental model: dose–response at five-week follow-up based on retrospective dose assessment in individual rats

Author

Pozzi, Emiliano C. C., Trivillin, Verónica A., Colombo, Lucas L., Monti Hughes, Andrea, Thorp, Silvia I., Cardoso, Jorge E., Garabalino, Marcela A., Molinari, Ana J., Heber, Elisa M., Curotto, Paula, Miller, Marcelo, Itoiz, Maria E., Aromando, Romina F., Nigg, David W., and Schwint, Amanda E.

Published
2013
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8. Boron neutron capture therapy (BNCT) for the treatment of liver metastases: biodistribution studies of boron compounds in an experimental model

Author

Garabalino, Marcela A., primary, Monti Hughes, Andrea, additional, Molinari, Ana J., additional, Heber, Elisa M., additional, Pozzi, Emiliano C. C., additional, Cardoso, Jorge E., additional, Colombo, Lucas L., additional, Nievas, Susana, additional, Nigg, David W., additional, Aromando, Romina F., additional, Itoiz, Maria E., additional, Trivillin, Verónica A., additional, and Schwint, Amanda E., additional

Published
2010
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9. Biodistribution of sodium borocaptate (BSH) for boron neutron capture therapy (BNCT) in an oral cancer model.

Author

Garabalino MA, Heber EM, Monti Hughes A, González SJ, Molinari AJ, Pozzi EC, Nievas S, Itoiz ME, Aromando RF, Nigg DW, Bauer W, Trivillin VA, and Schwint AE

Subjects
9,10-Dimethyl-1,2-benzanthracene, Animals, Carcinogens, Cricetinae, Disease Models, Animal, Mesocricetus, Mouth Neoplasms chemically induced, Tissue Distribution, Borohydrides pharmacokinetics, Boron Neutron Capture Therapy, Mouth Neoplasms metabolism, Sulfhydryl Compounds pharmacokinetics
Abstract

Boron neutron capture therapy (BNCT) is based on selective accumulation of ¹⁰B carriers in tumor followed by neutron irradiation. We previously proved the therapeutic success of BNCT mediated by the boron compounds boronophenylalanine and sodium decahydrodecaborate (GB-10) in the hamster cheek pouch oral cancer model. Based on the clinical relevance of the boron carrier sodium borocaptate (BSH) and the knowledge that the most effective way to optimize BNCT is to improve tumor boron targeting, the specific aim of this study was to perform biodistribution studies of BSH in the hamster cheek pouch oral cancer model and evaluate the feasibility of BNCT mediated by BSH at nuclear reactor RA-3. The general aim of these studies is to contribute to the knowledge of BNCT radiobiology and optimize BNCT for head and neck cancer. Sodium borocaptate (50 mg ¹⁰B/kg) was administered to tumor-bearing hamsters. Groups of 3-5 animals were killed humanely at nine time-points, 3-12 h post-administration. Samples of blood, tumor, precancerous pouch tissue, normal pouch tissue and other clinically relevant normal tissues were processed for boron measurement by optic emission spectroscopy. Tumor boron concentration peaked to therapeutically useful boron concentration values of 24-35 ppm. The boron concentration ratio tumor/normal pouch tissue ranged from 1.1 to 1.8. Pharmacokinetic curves showed that the optimum interval between BSH administration and neutron irradiation was 7-11 h. It is concluded that BNCT mediated by BSH at nuclear reactor RA-3 would be feasible.

Published
2013
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