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Your search keyword '"Claudia Pessoa"' showing total 4 results
Start Over Author "Claudia Pessoa" Journal quimica nova
4 results on '"Claudia Pessoa"'

1. A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina

Author

Aline Maria de Vita-Marques, Simone P. Lira, Roberto G. S. Berlinck, Mirna H. R. Seleghim, Sandra R. P. Sponchiado, Sâmia M. Tauk-Tornisielo, Margarida Barata, Claudia Pessoa, Manoel O. de Moraes, Bruno Coêlho Cavalcanti, Gislene G. F. Nascimento, Ana O. de Souza, Fabio C. S. Galetti, Célio L. Silva, Marcio Silva, Eli F. Pimenta, Otavio Thiemann, Michel R. Z. Passarini, and Lara D. Sette

Subjects
marine-derived fungi, screening, Beauveria felina, Chemistry, QD1-999
Abstract

Extracts obtained from 57 marine-derived fungal strains were analyzed by HPLC-PDA, TLC and ¹H NMR. The analyses showed that the growth conditions affected the chemical profile of crude extracts. Furthermore, the majority of fungal strains which produced either bioactive of chemically distinctive crude extracts have been isolated from sediments or marine algae. The chemical investigation of the antimycobacterial and cytotoxic crude extract obtained from two strains of the fungus Beauveria felina have yielded cyclodepsipeptides related to destruxins. The present approach constitutes a valuable tool for the selection of fungal strains that produce chemically interesting or biologically active secondary metabolites.

Published
2008
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2. PHYTOCHEMICAL STUDY ON ANTIMICROBIAL AND CYTOTOXIC ACTIVITY OF SPECIMENS OFLeonotis nepetifoliaL. R. (Br)

Author

Larissa Araújo Rolim, Marcília Pinheiro da Costa, Henrique C. L. Farias, Norberto Peporine Lopes, Ana Paula de Oliveira, Mariana Gama e Silva, Claudia Pessoa, Érica Martins de Lavor, Edigênia Cavalcante da Cruz Araújo, Amanda Leite Guimarães, Lucas Miranda Marques, Jackson Roberto Guedes da Silva Almeida, Alessandra Gomes Marques Pacheco, Raimundo Gonçalves de Oliveira Júnior, Rosemairy Luciane Mendes, and Camila de Souza Araújo

Subjects
chemistry.chemical_classification, Ethanol, biology, Traditional medicine, Stereochemistry, Flavonoid, Ethyl acetate, General Chemistry, Antimicrobial, biology.organism_classification, chemistry.chemical_compound, chemistry, Phytochemical, Chemical composition, Bacteria, Leonotis
Abstract

Specimens of Leonotis nepetiflolia were obtained from cultivated and wild environments to verify their influences in chemical composition. Phytochemical analyses were conducted for the ethyl acetate phase obtained by partitioning the crude ethanol extract from the cultivated leaves of L. nepetifolia. In doing so, flavonoid 3',4',5-trimethoxy-6,7-dihidroxyflavone (cirsiliol), a chemotaxonomic marker of the family Lamiaceae, was isolated. The results reveal that all phases and extracts tested exhibited weak to moderate antimicrobial activity against the strains of bacteria tested. The evaluation of in vitrocytotoxic and antitumor activity showed that the ethyl acetate phases obtained from both wild and cultivated leaves exhibit high potential cytotoxic and antitumor (> 78.0% of inhibition) activity. The major component of these phases was identified by high-performance liquid chromatography-diode array detector and nuclear magnetic resonance analyses using both 1D and 2D methods. The results further indicate that the flavonoid cirsiliol is the agent responsible for the activity observed in these phases.

Published
2015

3. Sensitive method for determination of piplartine, an alkaloid amide from Piper species, in rat plasma samples by liquid chromatography-tandem mass spectrometry

Author

Daniel P. Bezerra, Cláudia Pessoa, Manoel O. Moraes, Letícia V. Costa-Lotufo, Dayana Rubio Gouvea, Valquíria A. Polisel Jabor, Norberto Peporine Lopes, Keyller Bastos Borges, Mary Anne S. Lima, and Edilberto R. Silveira

Subjects
piplartine, LC-MS, rat plasma analysis, Chemistry, QD1-999
Abstract

Piplartine (PPTN) is an alkaloid amide found in Piper species that presents different activities. PPTN determination in rat plasma is necessary to better understand its biological effects. The aim of this study was to develop a sensitive LC-MS/MS method for the determination of PPTN in rat plasma. The performance criteria for linearity, sensitivity, precision, accuracy, recovery, and stability have been assessed and were within the recommended guidelines. The validated method proved to be suitable in a pilot study of PPTN kinetic disposition in rat plasma after a single intraperitoneal dose, and represents an appropriate tool to further pharmacokinetic studies.

Published
2012
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4. Composição química e atividade biológica de extrato oleoso de própolis: uma alternativa ao extrato etanólico Chemical composition and biological activity of oil propolis extract: an alternative to ethanolic extract

Author

Lilian Buriol, Daiane Finger, Eduardo Morgado Schmidt, Julio M. T. dos Santos, Marcos Roberto da Rosa, Sueli Pércio Quináia, Yohandra Reyes Torres, Herta Stutz Dalla Santa, Cláudia Pessoa, Manoel Odorico de Moraes, Letícia Veras Costa-Lotufo, Paulo Michel Pinheiro Ferreira, Alexandra Christine Helena Frankland Sawaya, and Marcos Nogueira Eberlin

Subjects
oil propolis extract, phenolic compounds, antibacterial and cytotoxic activities, Chemistry, QD1-999
Abstract

Propolis is mostly used as hydroalcoholic extract. Recently there has been a growing number of patents dealing with new solvents for preparing propolis extracts. This study aimed to prepare edible oil propolis extracts and compare their chemical composition and biological activity with ethanolic propolis extracts. ESI-MS and spectrophotometric methods were used for qualitative and quantitative analyses, respectively. Antibacterial activity was evaluated by diffusion in agar. Cytotoxicity was tested by MTT assay using tumor cell lines. The oil is able to extract bioactive compounds from propolis. Further studies are needed to improve extraction efficiency and to characterize the active components.

Published
2009
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