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Differences between climate conditions during the Last Glacial Maximum (LGM) and the Mid-Holocene (MH) in southern South America inferred from the state-of-the-art PMIP3 paleoclimatic simulations are described for the first time in this paper. The aim is to expose characteristics of past climate changes occurred without human influence. In this context, numerical simulations are an indispensable tool for inferring changes in near-surface air temperature and precipitation in regions where proxy information is scarce or absent. The analyzed PMIP3 models describe MH temperatures significantly warmer than those of LGM with magnitudes of change depending on the season and the specific geographic region. In addition, models indicate that seasonal mean precipitation during MH increased with respect to LGM values in wide southern continental areas to the east of the Andes Cordillera whereas seasonal precipitation developed in areas to the west of Patagonian Andes reduced from LGM to MH. [ABSTRACT FROM AUTHOR]