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ObjectiveStudies have suggested that total intake of trans-fatty acids (TFA) is positively associated with changes in body weight and waist circumference, whereas intake of TFA from ruminant dairy and meat products (R-TFA) has not been associated with weight gain. However, these previous studies are limited by self-reported measures of body weight and waist circumference or by a cross-sectional design. The objective of the present study was to investigate if R-TFA intake was associated with subsequent changes in anthropometry (body weight, waist and hip circumference) measured by technicians and body composition (body fat percentage).DesignA 6-year follow-up study. Information on dietary intake was collected through diet history interviews, and anthropometric and bioelectrical impedance measurements were obtained by trained technicians at baseline (1987–1988) and at follow-up (1993–1994). Multiple regression with cubic spline modelling was used to analyse the data.SettingCopenhagen County, Denmark.SubjectsTwo hundred and sixty-seven men and women aged 35–65 years from the Danish MONICA (MONItoring of trends and determinants in CArdiovascular diseases) cohort.ResultsThe median R-TFA intake was 1·3 g/d (5th, 95th percentile: 0·4, 2·7 g/d) or 0·6 % of the total energy intake (5th, 95th percentile: 0·2, 1·1 %). No significant associations were observed between R-TFA intake and changes in body weight, waist and hip circumference or body fat percentage.ConclusionsR-TFA intake within the range present in the Danish population was not significantly associated with subsequent changes in body size, shape or composition and the 95 % confidence intervals indicate that any relevant associations are unlikely to have produced these observations. [ABSTRACT FROM AUTHOR]

ObjectiveTo investigate the association between the intake of n-6 PUFA and subsequent change in body weight and waist circumference at different levels of the carbohydrate:protein ratio.DesignFollow-up study with anthropometric measurements at recruitment and on average 5·3 years later. Dietary intake was determined at recruitment by using an FFQ that was designed for the study and validated. We applied linear regression models with 5-year change in weight or waist circumference as outcome and including a two-way interaction term between n-6 PUFA and carbohydrate intakes, lower-order terms, protein intake, long-chain n-3 PUFA intake and other potential confounders. Due to adjustment for intake of protein, levels of carbohydrate indirectly reflect levels of the carbohydrate:protein ratio.SettingDiet, Cancer and Health follow-up study, Denmark.SubjectsWomen and men (n 29 152) aged 55 years.ResultsFor a high intake of n-6 PUFA (6·9 % of energy) v. a low intake of n-6 PUFA (3·4 % of energy), the difference in 5-year weight change was −189·7 g (95 % CI −636·8, 257·4 g) at a low carbohydrate:protein ratio and −86·7 g (95 % CI −502·9, 329·6 g) at a high carbohydrate:protein ratio; the differences in 5-year waist circumference change were 0·26 cm (95 % CI −0·47, 0·98 cm) and −0·52 cm (95 % CI −1·19, 0·15 cm), respectively. Inclusion of the dietary glycaemic index did not change the results.ConclusionsNo consistent associations between the intake of n-6 PUFA and change in body weight or waist circumference at different levels of the carbohydrate:protein ratio were observed. [ABSTRACT FROM AUTHOR]