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This study aimed to evaluate neuroendocrine responses and changes in perceptual asymmetry following an induced negative affect. Cortisol increasing in response to negative affect has been reported, while current brain models of emotion processing link negative affect to the right hemisphere. In this study, the Velten Mood Induction Procedure was used to generate neutral or negative affect in 44 healthy subjects. The PANAS scales were used to assess self-reported mood. A consonant-vowel dichotic listening (DL) test was applied after the neutral and negative affect inductions, and levels of salivary cortisol were determined by radioimmunoassay. For the negative affect condition, and congruent with the hypothesis tested, PANAS positive scores diminished (p<0.001) and PANAS negative scores increased (p<0.001), yielding an inverse correlation between them. A significant increase in cortisol levels was also seen (p<0.04). When taking cortisol reactivity into account, PANAS negative scores were higher for high-than for low-cortisol responders (p<0.02). Regarding DL, an increase in left ear items (p<0.04) and a decrease in right ear items (p<0.03) reported for those subjects who obtained a right ear advantage in the neutral condition. An explanation in terms of Kinsbourne's model for attentional-activation influences on DL is postulated and implications for the issue of affective illness are also discussed.