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The aim of this study was to investigate the effects on running performance of a within-session placebo procedure consisting of a conditioning treatment plus verbal communications. Twenty-six subjects were assigned to PLACEBO and CONTROL groups. Participants performed three sessions: Session 1-Cooper Test, Session 2-Baseline session and Session 3-Experimental session. During Session 2, participants performed a sprint-interval-training (SIT)-until-exhaustion preceded by a general warm-up, while in Session3 the SIT was preceded by a conditioning treatment (FIFA11+ warm-up), known to be effective in preventing injuries but not improving performance. Moreover, in Session3, only the PLACEBO group received verbal suggestions (before the warm-up) to influence participants' expectations about FIFA11+ effectiveness in improving performance, and deceptive feedback (during each SIT recovery bout) to increase the conditioning effect. To evaluate performance improvements, Running Time was chosen as a main outcome while to ensure participants reached exhaustion, physiological and metabolic responses were monitored. Total running distance (TRD) was also measured. Results showed that, Running Time and TRD significantly increased in the PLACEBO group whilst no differences in the CONTROL group were observed thus, suggesting the effectiveness of the within-session-placebo procedure in improving running performance. These findings shed a new light on the interaction between cognitive domain and performance, thus encouraging coaches to adopt this innovative method during the training protocol to enhance athletes' performance. Moreover, this placebo procedure, not requiring additional time, tools or resources, could represent a more ecological approach that can be easily adopted in the field. • A within-training session placebo procedure was administered. • Placebo consisted of a warm-up as conditioning treatment and verbal communications. • Verbal communications consisted of verbal suggestion and surreptitious manipulation. • Placebo procedure improved running time and total running distance. [ABSTRACT FROM AUTHOR]