The interpretation of cross-effects from vector autoregressive models to infer structure and causality among constructs is widespread and sometimes problematic. I describe problems in the interpretation of cross-effects when processes that are thought to fluctuate continuously in time are, as is typically done, modeled as changing only in discrete steps (as in e.g., structural equation modeling)-zeroes in a discrete-time temporal matrix do not necessarily correspond to zero effects in the underlying continuous processes, and vice versa. This has implications for the common case when the presence or absence of cross-effects is used for inference about underlying causal processes. I demonstrate these problems via simulation, and also show that when an underlying set of processes are continuous in time, even relatively few direct causal links can result in much denser temporal effect matrices in discrete-time. I demonstrate one solution to these issues, namely parameterizing the system as a stochastic differential equation and focusing inference on the continuous-time temporal effects. I follow this with some discussion of issues regarding the switch to continuous-time, specifically regularization, appropriate measurement time lag, and model order. An empirical example using intensive longitudinal data highlights some of the complexities of applying such approaches to real data, particularly with respect to model specification, examining misspecification, and parameter interpretation. (PsycInfo Database Record (c) 2024 APA, all rights reserved).