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Start Over Descriptor "SLC1A1" Journal psychiatry research
4 results on '"SLC1A1"'

1. Lack of association of SLC1A1 variants with schizophrenia in Chinese Han population.

Author

Lu, Weihong, Wu, Haisu, Cai, Jun, Wang, Zuowei, Yi, Zhenghui, Yu, Shunying, Fang, Yiru, and Zhang, Chen

Subjects
*SINGLE nucleotide polymorphisms, *PEOPLE with schizophrenia, *ALLELES, *DISEASE susceptibility, *DATA analysis
Abstract

Abstract: In this study, we analyzed four single nucleotide polymorphisms (SNPs) (rs10491734, rs2228622, rs301430 and rs301443) of the solute carrier family 1 gene (SLC1A1) in a set of 616 schizophrenia patients and 638 matched healthy controls of Han Chinese descent. No significant differences of genotype or allele distribution were identified between the patients and controls. Our data suggest that SLC1A1 is unlikely to be a major susceptibility gene for schizophrenia in Han Chinese. [Copyright &y& Elsevier]

Published
2013
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2. Association between the efficacy of fluoxetine treatment in obsessive-compulsive disorder patients and SLC1A1 in a Han Chinese population

Author

Leiming Cao, Wei Zhu, Qingzhong Wang, Zhang Kai, Min Zhao, Guoqiang Wang, and Hao Hu

Subjects
Adult, Male, Linkage disequilibrium, medicine.medical_specialty, Obsessive-Compulsive Disorder, MEDLINE, Linkage Disequilibrium, Young Adult, Asian People, Obsessive compulsive, Fluoxetine, medicine, Humans, Young adult, Association (psychology), Psychiatry, Biological Psychiatry, Genetic Association Studies, biology, business.industry, SLC1A1, Case-control study, Psychiatry and Mental health, Excitatory Amino Acid Transporter 3, Treatment Outcome, Case-Control Studies, Population Surveillance, biology.protein, Female, business, medicine.drug
Published
2015

3. Lack of association of SLC1A1 variants with schizophrenia in Chinese Han population

Author

Zuowei Wang, Shunying Yu, Zhenghui Yi, Yiru Fang, Haisu Wu, Weihong Lu, Jun Cai, and Chen Zhang

Subjects
Adult, Male, Genotype, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Asian People, medicine, Humans, Genetic Predisposition to Disease, Allele, Biological Psychiatry, Alleles, Genetic association, Genetics, Haplotype, SLC1A1, Case-control study, Genetic Variation, Middle Aged, medicine.disease, Psychiatry and Mental health, Excitatory Amino Acid Transporter 3, Haplotypes, Schizophrenia, Case-Control Studies, biology.protein, Female
Abstract

In this study, we analyzed four single nucleotide polymorphisms (SNPs) (rs10491734, rs2228622, rs301430 and rs301443) of the solute carrier family 1 gene (SLC1A1) in a set of 616 schizophrenia patients and 638 matched healthy controls of Han Chinese descent. No significant differences of genotype or allele distribution were identified between the patients and controls. Our data suggest that SLC1A1 is unlikely to be a major susceptibility gene for schizophrenia in Han Chinese.

Published
2013

4. Glutamate system genes and brain volume alterations in pediatric obsessive-compulsive disorder: a preliminary study

Author

Paul D. Arnold, James L. Kennedy, David R. Rosenberg, Philip C. Easter, Ke Wu, and Gregory L. Hanna

Subjects
Male, Candidate gene, Obsessive-Compulsive Disorder, Adolescent, Neuroscience (miscellaneous), Glutamic Acid, Nerve Tissue Proteins, behavioral disciplines and activities, Polymorphism, Single Nucleotide, Article, Neuroimaging, mental disorders, medicine, Image Processing, Computer-Assisted, Humans, Radiology, Nuclear Medicine and imaging, Genetic Predisposition to Disease, Child, Anterior cingulate cortex, Genetic Association Studies, biology, Putamen, SLC1A1, Brain, Magnetic Resonance Imaging, Psychiatry and Mental health, medicine.anatomical_structure, nervous system, Brain size, biology.protein, GRIN2B, Orbitofrontal cortex, Female, Psychology, Neuroscience
Abstract

Obsessive-compulsive disorder (OCD) has been associated with regional volumetric brain abnormalities, which provide promising intermediate phenotypes of the disorder. In this study, volumes of brain regions selected for a priori evidence of association with OCD (orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), thalamus, caudate, putamen, globus pallidus and pituitary) were measured using structural magnetic resonance imaging (MRI) in 20 psychotropic-naïve pediatric OCD patients. We examined the association between these regional brain volumes and a total of 519 single nucleotide polymorphisms (SNPs) from nine glutamatergic candidate genes (DLGAP1, DLGAP2, DLGAP3, GRIN2B, SLC1A1, GRIK2, GRIK3, SLITRK1 and SLITRK5). These genes were selected based on either previous reported association with OCD in humans or evidence from animal models of OCD. After correcting for multiple comparisons by permutation testing, no SNP remained significantly associated with volumetric changes. The strongest trend toward association was identified between two SNPs in DLGAP2 (rs6558484 and rs7014992) and OFC white matter volume (P = 0.000565, Padjusted= 0.3071). Our other top ranked association findings were with ACC, OFC and thalamus. These preliminary results suggest that sequence variants in glutamate candidate genes may be associated with structural neuroimaging phenotypes of OCD.

Published
2011

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