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3 results on '"Kalnak, Nelli"'

1. Developmental language disorder – heritability and genetic correlations with other disorders affecting language

Author

Banasik, Karina, Bay, Jakob, Kjærgaard Boldsen, Jens, Brodersen, Thorsten, Brunak, Søren, Demur, Alfonso Buil, Nordahl Christoffersen, Lea Arregui, Didriksen, Maria, Dinh, Khoa Manh, Dowsett, Joseph, Erikstrup, Christian, Feenstra, Bjarke, Geller, Frank, Gudbjartsson, Daniel, Hansen, Thomas Folkmann, Mikkelsen, Dorte Helenius, Hindhede, Lotte, Hjalgrim, Henrik, von Stemann, Jakob Hjorth, Jensen, Bitten Aagaard, Schork, Andrew Joseph, Kaspersen, Kathrine, Kjerulff, Bertram Dalskov, Kongstad, Mette, Mikkelsen, Susan, Mikkelsen, Christina, Nissen, Janna, Nyegaard, Mette, Ostrowski, Sisse Rye, Pedersen, Ole Birger, Elgaard Quinn, Liam James, Rafnar, Þórunn, Rohde, Palle Duun, Rostgaard, Klaus, Schwinn, Michael, Sørensen, Erik, Stefansson, Kari, Stefánsson, Hreinn, Thørner, Lise Wegner, Þorsteinsdóttir, Unnur, Bruun, Mie Topholm, Ullum, Henrik, Werge, Thomas, Westergaard, David, Nudel, Ron, Chrsitensen, Rikke Vang, Kalnak, Nelli, Lundberg, Mischa, Christoffersen, Lea Arregui Nordahl, Burgdorf, Kristoffer Sølvsten, Pedersen, Ole Birger Vesterager, Gísladóttir, Rósa S., and Walters, G. Bragi

Published
2024
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3. Developmental language disorder – heritability and genetic correlations with other disorders affecting language.

Author

Nudel, Ron, Chrsitensen, Rikke Vang, Kalnak, Nelli, Lundberg, Mischa, Schwinn, Michael, Sørensen, Erik, Mikkelsen, Christina, Nissen, Janna, Christoffersen, Lea Arregui Nordahl, Kjerulff, Bertram Dalskov, Hansen, Thomas Folkmann, Burgdorf, Kristoffer Sølvsten, Pedersen, Ole Birger Vesterager, Erikstrup, Christian, Gísladóttir, Rósa S., Walters, G. Bragi, Stefánsson, Hreinn, Ostrowski, Sisse Rye, and Werge, Thomas

Abstract

• SNP-based heritability of DLD was significant and estimated to be 27–52 % using genome-based restricted maximum likelihood and LD score regression. • No significant genetic correlation was found between DLD and other conditions in which spoken language and communication may be affected, namely, ASD, ADHD and schizophrenia. • DLD has a distinct genetic profile, not strongly associated with spoken-language traits measured in the general population. Developmental language disorder (DLD) is a neurodevelopmental disorder primarily affecting language in the absence of a known biomedical condition, which may have a large impact on a person's life and mental health. Family-based studies indicate a strong genetic component in DLD, but genetic studies of DLD are scarce. In this study we estimated the heritability of DLD and its genetic correlations with related disorders and traits in sample of >25,000 individuals from the Danish Blood Donor Study for whom we had both genotype data and questionnaire data on language disorder and language support. We estimated SNP-based heritabilities for DLD and genetic correlations with disorders which may involve spoken language deficits and traits related to spoken language. We found significant heritability estimates for DLD ranging from ∼27 % to ∼52 %, depending on the method used. We found no significant evidence for genetic correlation with the investigated disorders or traits, although the strongest effect was observed for a negative genetic correlation between DLD and nonword repetition ability. To our knowledge, this study reports the first significant heritability estimate for DLD from molecular genetic data. [ABSTRACT FROM AUTHOR]

Published
2024
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