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Objective: Substance use patterns and sociodemographic variables of Berlin's party scene were investigated to derive preventive measures and harm reduction services, which meet the needs of the consumers., Methods: A questionnaire was used online and in the field among Berlin partygoers (N = 877) and structured interviews (N = 20) were conducted with professionals working in this area, including social workers, emergency medical service, police and club owners and users., Results: A risky consumption pattern was found in 67 % of participants, who also stated need for counseling and a wish for reduction of their substance use. Of all preventive measures, drug checking was requested most often. Substances with the highest prevalence were alcohol, cannabis, amphetamine, MDMA, cocaine and ketamine, whereas methamphetamine and new psychoactive substances were barely stated., Conclusion: There is an urgent need to expand current preventive measures. There is a willingness of the scene to use according services, especially by those who need it the most., Competing Interests: Die Autoren geben an, dass kein Interessenkonflikt besteht. PD Dr. med. Stephan Köhler ist Teilnehmer des Charité Clinical Scientist Programms, finanziert durch die Charité – Universitätsmedizin Berlin und Berlin Institute of Health., (© Georg Thieme Verlag KG Stuttgart · New York.)