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Your search keyword '"Tsai, Shih-Jen"' showing total 18 results
Start Over Author "Tsai, Shih-Jen" Journal psychiatric genetics
18 results on '"Tsai, Shih-Jen"'

15. Association study of oestrogen receptor gene polymorphism and suicidal behaviours in major depressive disorder

Author

Tsai, Shih-Jen, Wang, Ying-Chieh, Hong, Chen-Jee, and Chiu, Hsien-Jane

Abstract

Gender comparison in epidemiological studies has consistently demonstrated a greater prevalence for major depressive disorders (MDD) in females. Several lines of evidence have implicated oestrogen pathways in this gender difference. Furthermore, there is evidence that attempted suicides are more frequent in women. A population-based association study was used to test the hypothesis that the genetic variants (PvuII and XbaI polymorphisms) of the oestrogen receptor gene (ER-) confer susceptibility to MDD.

Published
2003

16. Association analysis for dopamine D2 receptor Taq1 polymorphism with P300 event-related potential for normal young females

Author

Lin, Ching-Hua, Yu, Younger W.-Y., Chen, Tai-Jui, Tsai, Shih-Jen, and Hong, Chen-Jee

Abstract

P300 has been demonstrated abnormal for a variety of neuropsychiatric disorders, and heritability has been proposed. We analyzed the event-related potentials for three DRD2 genotype groups in 134 normal young females. The results demonstrate that there is no association for DRD2 genotype and P300 components. Our negative findings in normal subjects suggest association demonstrated for P300 latency and the DRD2 allele may be disease dependent.

Published
2001

18. Association study of oestrogen receptor alpha gene polymorphism and suicidal behaviours in major depressive disorder.

Author

Tsai SJ, Wang YC, Hong CJ, and Chiu HJ

Subjects
Base Sequence, DNA Primers, Disease Susceptibility, Estrogen Receptor alpha, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Polymerase Chain Reaction, Reference Values, Restriction Mapping, Sex Characteristics, Depressive Disorder genetics, Genetic Variation, Polymorphism, Genetic, Receptors, Estrogen genetics, Suicide
Abstract

Objective: Gender comparison in epidemiological studies has consistently demonstrated a greater prevalence for major depressive disorders (MDD) in females. Several lines of evidence have implicated oestrogen pathways in this gender difference. Furthermore, there is evidence that attempted suicides are more frequent in women. A population-based association study was used to test the hypothesis that the genetic variants ( II and I polymorphisms) of the oestrogen receptor alpha gene (ER-alpha) confer susceptibility to MDD., Methods: The ER-alpha was genotyped for 154 patients with MDD and 226 controls in a Chinese population., Results: Statistical analysis showed a significant difference in the II genotype and allele frequencies between the female MDD patients and the female controls ( P=0.010 and P=0.004, respectively). However, no significant differences in ER-alpha genotype or allele frequencies were found between male MDD patients and male controls. Furthermore, the ER-alpha genotypes were not associated with suicide-attempt history for MDD cases., Conclusions: Our results suggest that the ER-alpha may play a role in the susceptibility of MDD in females.

Published
2003
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