1. Genome scan of Tourette syndrome in a single large pedigree shows some support for linkage to regions of chromosomes 5, 10 and 13
- Author
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A M Dearlove, Hmd Gurling, Gursharan Kalsi, David Curtis, Peter Brett, Mary M. Robertson, and Andrew McQuillin
- Subjects
Genetic Markers ,Male ,Tics ,Genome Scan ,Locus (genetics) ,Tourette syndrome ,Genetic linkage ,Genetics ,medicine ,Humans ,Gene ,Biological Psychiatry ,Genetics (clinical) ,Autosome ,Chromosomes, Human, Pair 13 ,Chromosomes, Human, Pair 10 ,Genome, Human ,Haplotype ,Chromosome Mapping ,medicine.disease ,Pedigree ,Psychiatry and Mental health ,Chromosomes, Human, Pair 5 ,Female ,Psychology ,Tourette Syndrome - Abstract
Objectives To localize genes influencing the susceptibility three positive regions is conclusively implicated, to Gilles de la Tourette syndrome (GTS) and associated it seems probable that at least one contains a susceptibility chronic multiple tics (CMT). locus. We recommend that association-based studies.Method A single, large, multiple affected pedigree containing 35 subjects diagnosed with GTS and a further 14 with CMT was genotyped for markers spanning the autosomes. Linkage analysis was carried out using classical lod score analysis and model-free lod score analysis. All markers were subjected to two-point analysis, and markers producing a two-point result significant at P
- Published
- 2004