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The aim of the study was to evaluate knowledge about tobacco toxicity among patients hospitalized in Department of Internal Diseases, Pneumonology and Allergology in Warsaw and to examine their quality of life. The study comprised 51 people at age between 18-80 years, from Warsaw and its environs. They were hospitalized because of many reasons like: COPD or asthma exacerbation, cough and focal pulmonary lesions diagnostics, follow-up examinations because of sarcoidosis or pulmonary fibrosis. Data for analysis were achieved from anonymous questionnaire prepared by authors and filled by patients. Quality of life was assessed with EQ-5D Questionnaire. The tobacco addiction rate was assessed with the Fagerström questionnaire, and the motivation to quit smoking with the Schneider test. It was found that only 14% of hospitalized patients have never smoked cigarettes, 86% smoked in the past, and 29% declare regularly smoking in present. The most common pointed tobacco-related diseases were lung cancer and hearth diseases. People hospitalized because of COPD exacerbation (CHPOChP) had significantly lower level of quality of life than patients hospitalized because of asthma exacerbation (CHA) (p = 0.03), and this both groups had significantly lower level of quality of life than persons without obstructive pulmonary diseases (NCH) (NCH - CHPOChP p = 0.0004; NCH - CHA p = 0.04). The motivation to quit smoking in COPD smokers group was significantly lower than in group treated in the hospital because of other reasons (p = 0.004).

The aim of the study was to examine an alexithymia score and depression among people smoking cigarettes and also to examine association between alexithymia, depression and smoking index, nicotine addiction, the motivation to quit smoking. The study comprised 46 people from Warsaw and its environs, without pulmonary, cardiovascular or neoplastic diseases, with at least medium education. The subjects were qualified into two groups: group I (n = 22) - subjects who had never smoked cigarettes, and group II - currently smoking (n=24). The total alexithymia score and scores of alexithymia subscales: difficulty in identifying feelings (TIE), b) difficulty in communicating feelings (TOU), c) externally oriented thinking (OSM) were assessed with Toronto Alexi. thymia Scale 20 (TAS-20). Beck Depression Inventory (Scale) (BDI) was used to evaluate presence and intensification of depression symptoms. The tobacco addiction rate was assessed with the Fagestrom questionnaire, and the motivation to quit smoking with the Schneider test. All data were obtained during individual exami. nations. The mean alexithymia score in the nonsmokers group was 38.6+/-8.8, in the smokers group: 46.6+/-13.0. The differences between the groups were statistically significant (p=0.02). Both difficulty in identifying feelings (TIE) and difficulty in communicating feelings (TOU) scores were significantly higher in the smokers (TIE p=0.01; TOU p=0.03). There were no differences in externally oriented thinking. It was found that people smoking cigarettes had a significantly higher level of intensification of depression symptoms than the controls. There was not any correlation between the total alexithymia score and depression symptoms or smoking index, the degree of nicotine addiction, the motivation to quit smoking.

Telomerase synthesizes telomeric DNA repeats at the ends of eukaryotic chromosomes and inhibits the natural senescence of different cells. Its increased activity in malignant tumors is considered to be an independent prognostic factor of the disease course. Aim of the study was valuation of influence of prolonged tobacco smoking on telomerase expression in non-small cell lung cancer (NSCLC). The study comprised 33 patients with NSCLC (divided into two groups: smokers - n=21 and nonsmokers n=12), who had telomerase activity quantitatively assessed (PCR-ELISAPLUS, ROCHE, Mannheim, Germany) in aspirates collected from peripheral lung tumors through transthoracic fine-needle biopsy. No statistically significant differences were found between the studied groups with regard to the clinical stage of tumor. Telomerase activity in biopsy samples from smoking patients was higher than in samples from nonsmoking patients (statistically insignificant difference p=0.09). It was found that telomerase activity in tumor cells was significantly lower in patients smoking less than 40 pack years in comparison to patients smoking more than 40 pack-years (p=0.01). Telomerase activity in NSCLC cells correlated significantly with clinical stage of tumor in all the patients (r=0.66 for nonsmokers and r=0.58 for smokers; por =0.01), and in the smokers' group - additionally with pack-years (r=0.47; p=0.04). Tobacco smoking by patients with non-small cell lung cancer increases telomerase activity in tumor cells.

The aim of the study was to assess the influence of smoking on the metalloproteinase 1 (MMP-1) concentration in serum in the group of patients with chronic obstructive pulmonary disease (COPD). The study comprised 26 patients with COPD. The control group was created of 15 healthy non-smoking subjects. In the both group spirometry test was performed. The concentration of MMP-1, C-reactive protein, OB level was estimated in serum. Significant differences were noticed in the MMP-1 concentration in serum between groups (p=0.013). Significantly higher OB level (p=0.011) and C-reactive protein concentration (p=0.03) was found in the COPD group. In this same group positive correlation between MMP-1 concentration in serum and the packyears was noticed (r=0.50). No significant correlation was found between inflammatory indicators and the number of packyears. No significant correlation was noticed between MMP-1 level and FEV1 in COPD group. The analysis of the data shows significant influence of smoking on the increase of MMP-1 concentration in serum in the group of COPD patients.

The aim of the study was to assess differences in tobacco addiction rate and motivation to quit tobacco smoking in patients with bronchial asthma and chronic obstructive pulmonary disease (COPD). The study comprised 384 males from Warsaw and its environs, aiming to quit smoking within the nearest year, without cardiovascular or neoplastic diseases, with at least medium education (17.19). The subjects were qualified into one of three groups: a control group--subjects without pulmonary diseases (n=143), patients with COPD (n=126) and patients with bronchial asthma (n=115). The smoking index (pack-years) was calculated in each group. The tobacco addiction rate was assessed with the Fageström questionnaire, and the motivation to quit smoking with the Schneider test. All data were obtained during individual examinations. The mean smoking index in the study population was 29.0 +/- 20.6 pack-years (control--27.0 +/- 20.6; asthma--25.2 +/- 14.2 and COPD--38.0 +/- 21.4). A high tobacco addiction rate was found in 40.5% of the patients with COPD, 37.1% of the patients with asthma and 30.3% of the subjects from the control group. The differences between the groups were not statistically significant (p0.05). In the asthmatic group the percentage of subjects with a high motivation to quit smoking was significantly lower (48%) than in the COPD group (74%, p=0.005) and the control group (75%, p=0.002). It was found that patients with COPD significantly more frequently than asthmatics and people without pulmonary diseases need medical assistance in overcoming nicotine addiction.

The aim of the study was to analyze to what extend the principles of minimum intervention are applied by basic health care doctors in Mazovia. The study comprised 326 tobacco smokers, divided into two groups: group I--including 160 adults living in towns with a population below 10000 and group II--including 166 inhabitants of towns with a population above 100000. Each subject had their tobacco dependence rate (the Fagerström test) and the period of smoking (pack-years) calculated. Each subject evaluated application of the minimum intervention principles by their basic health care doctor anonymously. The data obtained were statistically analyzed. The study groups did not differ in terms of nicotine addiction rate. It was found that almost half of the patients smoking tobacco had never been asked by their doctor about smoking habit during consultation. An educational material concerning the harmfulness of smoking is received by every seventh smoker, and an attempt of a pharmacological therapy of addiction is undertaken only in every tenth patient. The minimum medical intervention principles in tobacco smokers are twice more often applied by basic health care doctors working in small towns.

The aim of the study was assessment of the influence of tobacco smoking on direct costs of in-hospital treatment of chronic obstructive pulmonary disease exacerbations (COPD). 112 men who underwent in-hospital treatment of exacerbation of moderate COPD in the years 2001-2002 were included in the study. The patients were qualified into one of three groups: I--never-smoking patients (n=40); II--former smokers (n=42); III--active smokers (n=30). The mean age of patients was 70.9 +/- 8.9 years (I--74.8 +/- 7.4; II--68.4 +/- 9.4; III--69.4 +/- 9.8). The mean direct cost of COPD patient treatment was PLN 2162.00 +/- 920.90 (I--PLN 2025.50 +/- 681.30; II--PLN 1875.80 +/- 608.70; III--PLN 2744.60 +/- 1266.20). The mean period of smoking was 18.3 pack-years in the group II and 27.7 pack-years in the group III. No significant differences in FEV1 were found between the groups. No significant differences were found in the treatment costs between the groups I and II. It was demonstrated that the costs of in-hospital COPD treatment are significantly higher in the group III than in the groups I and II. A linear regression formula was calculated, showing a linear relationship between each consecutive pack-year of addiction and the costs of exacerbation treatment in the group III (R=0.39, R2=0.13, standardized BETA index = 24.0; p0.03). No similar relationship was found in the former smokers' group. The analysis of the data shows that: (1) active tobacco smoking by patients is related to significantly higher direct costs of in-hospital treatment of COPD exacerbations than in case of never-smoking patients or patients who smoked in the past, and (2) the costs of in-hospital treatment of COPD exacerbations in case of people who have stopped smoking are comparable to the costs of hospitalization of never-smoking patients with COPD.