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Start Over Author "Link, Andrew J." Journal proteomics
13 results on '"Link, Andrew J."'

2. Targeted Identification of Protein Interactions in Eukaryotic mRNA Translation

Author

Link, Andrew J., primary, Niu, Xinnan, additional, Weaver, Connie M., additional, Jennings, Jennifer L., additional, Duncan, Dexter T., additional, McAfee, K. Jill, additional, Sammons, Morgan, additional, Gerbasi, Vince R., additional, Farley, Adam R., additional, Fleischer, Tracey C., additional, Browne, Christopher M., additional, Samir, Parimal, additional, Galassie, Allison, additional, and Boone, Braden, additional

Published
2020
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5. Proteomics show antigen presentation processes in human immune cells after AS03-H5N1 vaccination

Author

Galassie, Allison C., primary, Goll, Johannes B., additional, Samir, Parimal, additional, Jensen, Travis L., additional, Hoek, Kristen L., additional, Howard, Leigh M., additional, Allos, Tara M., additional, Niu, Xinnan, additional, Gordy, Laura E., additional, Creech, C. Buddy, additional, Hill, Heather, additional, Joyce, Sebastian, additional, Edwards, Kathryn M., additional, and Link, Andrew J., additional

Published
2017
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6. Front Cover: Proteomics show antigen presentation processes in human immune cells after AS03-H5N1 vaccination

Author

Galassie, Allison C., primary, Goll, Johannes B., additional, Samir, Parimal, additional, Jensen, Travis L., additional, Hoek, Kristen L., additional, Howard, Leigh M., additional, Allos, Tara M., additional, Niu, Xinnan, additional, Gordy, Laura E., additional, Creech, C. Buddy, additional, Hill, Heather, additional, Joyce, Sebastian, additional, Edwards, Kathryn M., additional, and Link, Andrew J., additional

Published
2017
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9. Guidelines for the next 10 years of proteomics

Author

Wilkins, Marc R., primary, Appel, Ron D., additional, Van Eyk, Jennifer E., additional, Chung, Maxey C. M., additional, Görg, Angelika, additional, Hecker, Michael, additional, Huber, Lukas A., additional, Langen, Hanno, additional, Link, Andrew J., additional, Paik, Young-Ki, additional, Patterson, Scott D., additional, Pennington, Stephen R., additional, Rabilloud, Thierry, additional, Simpson, Richard J., additional, Weiss, Walter, additional, and Dunn, Michael J., additional

Published
2006
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13. Quantitative analysis of the secretome of TGF-beta signaling-deficient mammary fibroblasts.

Author

Xu BJ, Yan W, Jovanovic B, An AQ, Cheng N, Aakre ME, Yi Y, Eng J, Link AJ, and Moses HL

Subjects
Amino Acid Sequence, Animals, Cell Line, Cell Movement, Cell Proliferation, Fibroblasts metabolism, Mammary Glands, Animal cytology, Mammary Glands, Animal metabolism, Mice, Protein Serine-Threonine Kinases deficiency, Protein Serine-Threonine Kinases metabolism, Proteome metabolism, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta deficiency, Receptors, Transforming Growth Factor beta metabolism, Fibroblasts chemistry, Mammary Glands, Animal chemistry, Proteome analysis, Signal Transduction, Transforming Growth Factor beta metabolism
Abstract

Transforming growth factor beta (TGF-beta) is a master regulator of autocrine and paracrine signaling pathways between a tumor and its microenvironment. Decreased expression of TGF-beta type II receptor (TbetaRII) in stromal cells is associated with increased tumor metastasis and shorter patient survival. In this study, SILAC quantitative proteomics was used to identify differentially externalized proteins in the conditioned media from the mammary fibroblasts with or without intact TbetaRII. Over 1000 proteins were identified and their relative differential levels were quantified. Immunoassays were used to further validate identification and quantification of the proteomic results. Differential expression was detected for various extracellular proteins, including proteases and their inhibitors, growth factors, cytokines, and extracellular matrix proteins. CXCL10, a cytokine found to be up-regulated in the TbetaRII knockout mammary fibroblasts, is shown to directly stimulate breast tumor cell proliferation and migration. Overall, this study revealed hundreds of specific extracellular protein changes modulated by deletion of TbetaRII in mammary fibroblasts, which may play important roles in the tumor microenvironment. These results warrant further investigation into the effects of inhibiting the TGF-beta signaling pathway in fibroblasts because systemic inhibition of TGF-beta signaling pathways is being considered as a potential cancer therapy.

Published
2010
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