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Start Over Author "Di Ilio, Carmine" Journal proteomics
5 results on '"Di Ilio, Carmine"'

1. Oxidative modifications of cerebral transthyretin are associated with multiple sclerosis

Author

Pieragostino, Damiana, primary, Del Boccio, Piero, additional, Di Ioia, Maria, additional, Pieroni, Luisa, additional, Greco, Viviana, additional, De Luca, Giovanna, additional, D'Aguanno, Simona, additional, Rossi, Claudia, additional, Franciotta, Diego, additional, Centonze, Diego, additional, Sacchetta, Paolo, additional, Di Ilio, Carmine, additional, Lugaresi, Alessandra, additional, and Urbani, Andrea, additional

Published
2013
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4. Differential post‐translational modifications of transthyretin in Alzheimer's disease: A study of the cerebral spinal fluid

Author

Biroccio, Antonino, primary, del Boccio, Piero, additional, Panella, Marta, additional, Bernardini, Sergio, additional, Di Ilio, Carmine, additional, Gambi, Domenico, additional, Stanzione, Paolo, additional, Sacchetta, Paolo, additional, Bernardi, Giorgio, additional, Martorana, Alessandro, additional, Federici, Giorgio, additional, Stefani, Alessandro, additional, and Urbani, Andrea, additional

Published
2006
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5. Oxidative modifications of cerebral transthyretin are associated with multiple sclerosis

Author

Diego Franciotta, Maria di Ioia, Andrea Urbani, Piero Del Boccio, Luisa Pieroni, Damiana Pieragostino, Diego Centonze, Giovanna De Luca, Alessandra Lugaresi, Claudia Rossi, Simona D'Aguanno, Carmine Di Ilio, Paolo Sacchetta, V. Greco, Pieragostino Damiana, Del Boccio Piero, Di Ioia Maria, Pieroni Luisa, Greco Viviana, De Luca Giovanna, D'Aguanno Simona, Rossi Claudia, Franciotta Diego, Centonze Diego, Sacchetta Paolo, Di Ilio Carmine, Lugaresi Alessandra, and Urbani Andrea

Subjects
Adult, Male, medicine.medical_specialty, endocrine system, Multiple Sclerosis, Oxidative phosphorylation, Biochemistry, Myelin, Cerebrospinal fluid, Internal medicine, Case-Control Studies, Female, Humans, Middle Aged, Oxidation-Reduction, Prealbumin, Protein Isoforms, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Thyroxine, Protein Processing, Post-Translational, medicine, Matrix-Assisted Laser Desorption-Ionization, transthyretin, multiple sclerosis, cerebrospinal fluid, proteomics, Remyelination, Molecular Biology, Settore BIO/10 - BIOCHIMICA, Protein Processing, biology, Chemistry, Spectrometry, Multiple sclerosis, Settore BIO/12, Post-Translational, nutritional and metabolic diseases, Mass, medicine.disease, Transthyretin, medicine.anatomical_structure, Endocrinology, Immunology, biology.protein, Protein folding, Settore MED/26 - Neurologia, Cysteine
Abstract

Transthyretin (TTR) is a homotetrameric protein of the CNS that plays a role of as the major thyroxine (T4) carrier from blood to cerebrospinal fluid (CSF). T4 physiologically helps oligodendrocyte precursor cells to turn into myelinating oligodendrocytes, enhancing remyelination after myelin sheet damage. We investigated post-translational oxidative modifications of serum and CSF TTR in multiple sclerosis subjects, highlighting high levels of S-sulfhydration and S-sulfonation of cysteine in position ten only in the cerebral TTR, which correlate with an anomalous TTR protein folding as well as with disease duration. Moreover, we found low levels of free T4 in CSF of multiple sclerosis patients, suggestive of a potential role of these modifications in T4 transport into the brain.

Published
2012

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