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Start Over Author "Sabrina Rüggeberg" Journal protein & peptide letters
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1. Detection of a γ-Carboxy-Glutamate as Novel Post-Translational Modification of Human Transthyretin

Author

Peter Vajkoczy, Xinping Li, Thomas Franz, Sabrina Rüggeberg, and Peter Horn

Subjects
biology, Glutamate receptor, nutritional and metabolic diseases, General Medicine, Biochemistry, Molecular biology, Transthyretin, Cerebrospinal fluid, Post translational, Structural Biology, Proteome, biology.protein, Posttranslational modification, Peptide sequencing, Binding site
Abstract

During analysis of the proteome in the cerebrospinal fluid (CSF) of the Caucasian form of moyamoya disease (MMD), a novel post-translational modification of human transthyretin was observed. Two-dimensional electrophoresis and subsequent peptide sequencing with ESI-MS/MS were performed to discover the gamma-carboxylation of the Glu-42 (Gla-42).

Published
2008
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