1. Tongue coating microbiome as a potential biomarker for gastritis including precancerous cascade
- Author
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Hongfei Cui, Xuegong Zhang, Mingran Yang, Junfeng Li, Liyang Liu, Cui Jiaxing, Shao Li, Yingxue Li, and Shiyu Du
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.drug_class ,Antibiotics ,lcsh:Animal biochemistry ,Campylobacter concisus ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,Tongue ,Drug Discovery ,medicine ,Humans ,Microbiome ,lcsh:QH573-671 ,lcsh:QP501-801 ,tongue coating ,metagenomics ,biology ,lcsh:Cytology ,business.industry ,Microbiota ,non-invasive biomarker ,gastritis ,Cancer ,Cell Biology ,Middle Aged ,medicine.disease ,biology.organism_classification ,030104 developmental biology ,medicine.anatomical_structure ,Metagenomics ,Case-Control Studies ,030220 oncology & carcinogenesis ,Immunology ,Biomarker (medicine) ,Female ,Gastritis ,medicine.symptom ,business ,Precancerous Conditions ,Biomarkers ,Research Article ,Biotechnology - Abstract
The development of gastritis is associated with an increased risk of gastric cancer. Current invasive gastritis diagnostic methods are not suitable for monitoring progress. In this work based on 78 gastritis patients and 50 healthy individuals, we observed that the variation of tongue-coating microbiota was associated with the occurrence and development of gastritis. Twenty-one microbial species were identified for differentiating tongue-coating microbiomes of gastritis and healthy individuals. Pathways such as microbial metabolism in diverse environments, biosynthesis of antibiotics and bacterial chemotaxis were up-regulated in gastritis patients. The abundance of Campylobacter concisus was found associated with the gastric precancerous cascade. Furthermore, Campylobacter concisus could be detected in tongue coating and gastric fluid in a validation cohort containing 38 gastritis patients. These observations provided biological evidence of tongue diagnosis in traditional Chinese medicine, and indicated that tongue-coating microbiome could be a potential non-invasive biomarker, which might be suitable for long-term monitoring of gastritis. Electronic supplementary material The online version of this article (10.1007/s13238-018-0596-6) contains supplementary material, which is available to authorized users.
- Published
- 2018