1. A defect in thromboxane A2 synthesis may be a factor predisposing to cancer.
- Author
-
Horrobin DF, Karmali RA, Manku MS, Ally AI, Morgan RO, Cunnane SC, and Karmazyn M
- Subjects
- Animals, DNA genetics, DNA metabolism, Humans, Mutation, Neoplasms etiology, Neoplasms therapy, Prostaglandins biosynthesis, Psoriasis complications, Radiation Injuries complications, Thromboxane A2 metabolism, Thromboxane A2 radiation effects, Ultraviolet Rays, Xeroderma Pigmentosum complications, Neoplasms metabolism, Thromboxane A2 biosynthesis, Thromboxanes biosynthesis
- Abstract
A failure of thromboxane (TX) A2 synthesis may be a factor in cancer. Such a loss could explain the susceptibility to mutation, the excess prostaglandin production, the glycolytic mode of metabolism and the deranged calcium pumping characteristic of cancers. Ionising radiation and phorbols both have actions similar to inhibitors of TXA2 synthesis whereas colchicine and oxygen have actions consistent with stimulation of TXA2 synthesis. The concept accounts logically for hitherto unexplained features of cancer and suggests new strategies for the prevention and treatment of cancer.
- Published
- 1978
- Full Text
- View/download PDF