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Background To detect the optimal timing of intervention based on different cervical vertebral maturation stage (CS1-2 vs. CS3-4) for the treatment of Class III malocclusion with early Class III protocol. Methods A total sample of 43 patients (23 females, 20 males) ranging between 7 and 13 years of age with dentoskeletal Class III malocclusion treated with the modified SEC III (Splints, Elastic and Chincup) protocol divided into two groups based on the cervical vertebral maturation stages (CS1-2 and CS3-4) was included in this retrospective observational longitudinal study. Patient compliance was assessed using a 2-point Likert scale. Statistical comparisons between the two groups were performed with independent sample t tests. Results No statistically significant differences for any of the cephalometric variables describing the baseline dentoskeletal features were found between the two groups except for the mandibular unit length that was significantly greater in the pubertal group (P = 0.005). The modified SEC III protocol produced favorable sagittal outcomes in both groups, whereas no statistically significant T1-T2 changes were found between the CS1-2 and CS3-4 groups for any of the angular and linear measurements. No significant differences were found in the prevalence rates of the degree of collaboration between the two groups (P = 1.000). Conclusions No significant differences between prepubertal and pubertal patients were found in the sagittal and vertical dentoskeletal changes with the modified SEC III protocol. Thus, this early Class III treatment produced similar favorable effects in growing subjects regardless of the cervical vertebral maturation stages from CS1 to CS4.

Background Excessive proclination of lower incisors and other undesirable consequences usually result from the use of class II elastics during orthodontic treatment. The purpose of this study was to attempt to limit the adverse effects of class II elastics by the use of mini implants placed in the mandibular arch in adolescent class II female patients. Methods The sample comprised 28 patients, (a mean age of 15.66 ± 2 years for intervention group and 15.1 ± 2.2 years for conventional group) with one-fourth or one-half unit class II canine relationship. The sample was divided into two equal groups. Randomization was carried out by a computer sequence generator with a 1:1 allocation ratio. In the intervention group, the mini implants were inserted between the lower second premolar and first molar, while the conventional group underwent regular class II elastics therapy. The active elastics treatment time was 8 months for both groups. Results were assessed by measurements from pre- and post-elastics lateral cephalometric radiographs. Results The change in L1 inclination (0.97 ± 0.92°) and L1 AP position (0.31 ± 0.63 mm) did not show a statistically significant difference between the two groups, but a statistically significant difference was found in the U1 retroclination (5.23 ± 1.92°) and U1 distal movement (4.05 ± 1.4 mm) [P ˂ 0.001] and [P ˂ 0.05] respectively in favor of the intervention group. Conclusion Mini-implants in conjunction with class II elastics had no skeletal effect, mainly dentoalveolar and it did not prevent the proclination of lower incisors. There was more distal movement in the upper incisors in the skeletal anchorage group which helped in enhancing the camouflaging of class II malocclusion. Trial registration Trial registered “FUE.REC (10)/10-2018” at the FUE registration council for clinical trials/IOP Orthodontic Program October 2018.

Aim To evaluate the maxillary dentition effects of the extrusion arch for anterior open bite (AOB) correction in mixed dentition patients. Materials and methods Fourteen subjects with an initial mean age of 9.17 ± 1.03 years presenting with dentoalveolar AOB (mean − 1.28 ± 1.46 mm) and normal facial pattern (FMA = 25.76°) were treated with an extrusion arch. The mean treatment period was 7.79 ± 2.58 months. Lateral cephalograms and dental models were taken before (T0) and after the correction of AOB (T1). Data were analyzed using paired t test to evaluate differences between T0 and T1. For all tests, a significance level of P < .05 was used. Results All patients achieved positive overbite at T1, with a mean increase of 3.07 mm. The maxillary incisors extruded 1.94 mm. Retroclination of the maxillary incisors (− 6.15°) and an increase in the interincisal angle (5.57°) were observed. There was a significant decrease in the distance between the incisal edge of the maxillary incisors and the molars (− 2.21 mm). There was significant mesial tipping of the maxillary molar (− 11.49°). Significant reductions of overjet (− 1.65 mm), arch perimeter (− 3.02 mm), and arch length (− 2.23 mm) were noted. The transverse maxillary intermolar distance did not change significantly. Conclusions The use of a maxillary extrusion arch was effective in the treatment of AOB. Overbite increased due to incisor extrusion, as well as retroinclination and overjet reduction. However, side effects, such as mesial molar tipping and decreases in arch perimeter and length might occur.

Background Emoji are pictograms frequently used in social networks capable of expressing emotions. These tools can provide insights into people's behavior that could not be obtained with the use of textual communication. Recently, emoji have been introduced to various research fields as successful alternatives to word-based questionnaires for measure emotional responses. The objective of this study was to preliminarily evaluate the discriminating ability and relationship of these tools with different occlusal conditions/malocclusions. Methods Online surveys were applied to adult individuals (n = 201; mean age = 27.4 ± 5.7; 37.3% males, 62.7% females). Subjects issued acceptance scores (10-point scale) and expressed their emotional status using a 30-emoji list in relation to nine occlusal conditions: C1–crowding, C2–anterior open bite, C3–interincisal diastema, C4–increased overjet + deep bite (Class II div. 1), C5–anterior crossbite (Class III), C6–ideal occlusion, C7–unilateral posterior crossbite, C8–anterior open bite plus bilateral posterior crossbite plus crowding, and C9–deep bite (Class II div. 2). Cochran's Q and McNemar tests were used to compare the frequencies of choice of emoji between conditions. Correspondence analyses were applied to assess the association between occlusal conditions and emoji. Kendall's correlation coefficient was calculated to evaluate the relationship between mean acceptance scores and frequency counts of each emoji. Results The frequency of choice between conditions showed a significant difference for 25 of the 30 emoji (P Emoji were grouped predominantly based on their emotional valence (positive/negative) and arousal/activation (high/low). Positive emoji were associated with the most accepted conditions (i.e., C6, C3), while negative emoji with the most rejected ones (i.e., C8, C1, C2). Although only weak, positive correlations between acceptance and positively valenced emoji, and negative correlations between acceptance and negatively valenced emoji were observed (P Conclusions Emoji have an adequate discriminatory ability and would allow determining emotional profiles in the face of different occlusal conditions. Further research is necessary to consolidate the use of these tools in an instrument that allows measuring emotional responses.

Background The purpose of this study was to compare the stress distribution and displacement patterns of the one versus two maxillary molars distalization with iPanda and to evaluate the biomechanical effect of distalization on the iPanda using the finite element method. Methods The finite element models of a maxillary arch with complete dentition, periodontal ligament, palatal and alveolar bone, and an iPanda connected to a pair of midpalatal miniscrews were created. Two models were created to simulate maxillary molar distalization. In the first model, the iPanda was connected to the second molar to simulate a single molar distalization. In the second model, the iPanda was connected to the first molar to simulate “en-masse” first and second molar distalization. A varying force from 50 to 200 g was applied. The stress distribution and displacement patterns were analyzed. Results For one molar, the stress was concentrated at the furcation and along the distal surface in all roots with a large amount of distalization and distobuccal crown tipping. For two molars, the stress in the first molar was 10 times higher than in the second molar with a great tendency for buccal tipping and a minimal amount of distalization. Moreover, the stress concentration on the distal miniscrew was six times higher than in the mesial miniscrew with an extrusive and intrusive vector, respectively. Conclusions Individual molar distalization provides the most effective stress distribution and displacement patterns with reduced force levels. In contrast, the en-masse distalization of two molars results in increased force levels with undesirable effects in the transverse and vertical direction.

Background The aim of this systematic review was to identify, evaluate, and provide a current literature about the influence of heritability on the determination of occlusal traits. Materials and methods MEDLINE, SCOPUS, Web of Science, LILACS, and Google Scholar were searched without restrictions up to March 2020. Studies with twin method were considered and the risk of bias assessment was performed using quality of genetic association studies checklist (Q-Genie). The coefficient of heritability (h2), model-fitting approaches, and coefficient correlation were used to estimate the genetic/environmental influence on occlusal traits. The GRADE tool was used to assess the quality of the evidence. Results Ten studies met the eligibility criteria. Three studies presented good quality, five moderate quality, and two poor quality. Most studies have found that the intra-arch traits, mainly the maxillary arch morphology, such as width (h2 16–100%), length (h2 42–100%), and shape (h2 42–90%), and the crowding, mainly for mandibular arch (h2 35–81%), are under potential heritability influence. The traits concerning the inter-arch relationship, as overjet, overbite, posterior crossbite, and sagittal molar relation, seem not to be genetically determined. The certainty of the evidence was graded as low for all outcomes. Conclusions Although weak, the available evidence show that the heritability factors are determinant for the intra-arch traits, namely, arch morphology and crowding. Possibly due they are functionally related, the occlusal traits concerning the maxillary and mandibular relationship seem to have environmental factors as determinants. In this scenario, early preventive approaches can offer a more effective and efficient orthodontic treatment.

Background This study aimed to examine end-of-treatment outcomes of severe Class II Division I malocclusion patients treated with surgical or non-surgical approaches. This study tests the hypotheses that occlusal outcomes (ABO-OGS) and cephalometric outcomes differ between these groups. Methods A total of 60 patients were included: 20 of which underwent surgical correction and 40 of which did not. Cast grading of initial and final study models was performed and information was gathered from pre- to post-treatment cephalometric radiographs. The end-of-treatment ABO-OGS and cephalometric outcomes were compared to Mann-Whitney U tests and multivariable linear regression models. Results Following adjustment for multiple confounders (age, gender, complexity of case, and skeletal patterns), the final deband score (ABO-OGS) was similar for both groups (23.8 for surgical group versus 22.5 for non-surgical group). Those treated surgically had a significantly larger reduction in ANB angle, 3.4° reduction versus 1.5° reduction in the non-surgical group (p = 0.002). The surgical group also showed increased maxillary incisor proclination (p = 0.001) compared to the non-surgical group. This might be attributed to retroclination of maxillary incisors during treatment selection in the non-surgical group—namely, extraction of premolars to mask the discrepancy. Conclusions Those treated surgically had a significantly larger reduction in ANB angle and increased maxillary incisor proclination compared to those treated non-surgically with no significant changes in occlusal outcomes.

Background The purpose of this study was to evaluate the treatment effectiveness of Carriere Distalizer in comparison to Class II intermaxillary elastics and Forsus. Methods Three groups of patients treated with Class II intermaxillary elastics (n = 18), Carriere Distalizer (n = 18), and Forsus appliance (n = 18) were collected from three private orthodontic practices. Inclusion criteria were as follows: (1) 10–14 years old of start age with permanent dentition, (2) no history of previous orthodontic treatment, (3) complete pre- and post-treatment records, (4) dental Class II division 1 (end-to-end or more), (5) no pre-treatment transverse discrepancy, (6) non-extraction treatment plan, and (7) Class I post-treatment occlusal relationship. The data consisted of cephalometric and study model measurements from pre- and post-treatment records and treatment time. Two-tail Student t test was used to analyze the differences in cephalometric changes and dental corrections between Carriere Distalizer group and Class II elastics/Forsus group. Results All three groups of patients showed no differences in the age of treatment initiation, pre-treatment cephalometric measurements and discrepancy index (DI). The time of Class II correction for Carriere Distalizer was significantly shorter than that for Class II elastics; there was no difference in the length of Class II correction between Carriere Distalizer and Forsus groups. The amount of Class II correction (canine/molar relationship) was significantly lower for Carriere Distalizer when compared with Forsus appliance. Carriere Distalizer, similarly to Class II elastics, did not induce any statistically significant correction in skeletal component (ANB and Wits appraisal). Conclusions There is no clinically significant skeletal correction induced by Carriere Distalizer in growing patients. Carriere Distalizer can be applied to treatment of mild to moderate Class II dental malocclusion over 6 months on average, although the total treatment time may be prolonged due to various side effects. Overall, the Carriere Distalizer appears to be no more effective or efficient than alternatives in the treatment of Class II malocclusion.

Background To describe an esthetic orthodontic treatment using aligners in an adult patient with class II subdivision associated with crowding and dental crossbite. An 18-year-old hyperdivergent male patient with skeletal class II from mandibular retrusion presented for an orthodontic treatment. Occlusally, the patient presents class II subdivision, crossbite at tooth 4.4, an upper midline deviated towards the left with respect to the lower and facial midlines, and slight crowding in both arches. The patient refused conventional fixed multibracket treatment in favor of aligners. Pre- and post-treatment records as well as 1-year follow-up records are presented. Findings Treatment objectives were achieved in 12 months, and the patient was satisfied with the functional and esthetic outcomes, which were stable at 1 year. Conclusion Combining aligners with appropriate auxiliaries is an efficacious means of resolving orthodontic issues such as class II, dental crossbite, and crowding in a time-frame comparable to that of conventional fixed orthodontics. Furthermore, this system is associated with optimal oral hygiene and excellent esthetics.

The aim of this pilot randomized controlled trial (RCT) was to evaluate the sagittal mandibular response induced by rapid maxillary expansion (RME) therapy in mixed dentition patients with class II malocclusion, comparing the effects of bonded RME and banded RME with a matched untreated class II control group. This RCT was designed in parallel with an allocation ratio of 1:1:1. The sample consisted of 30 children with a mean age of 8.1 ± 0.6 years who were randomly assigned to three groups: group 1 treated with bonded RME, group 2 treated with banded RME, and group 3 the untreated control group. All patients met the following inclusion criteria: early mixed dentition, class II molar relationship, transverse discrepancy ≥ 4 mm, overjet ≥ 5 mm, and prepubertal skeletal maturity stage (CS1–CS2). The expansion screw was activated one quarter of a turn per day (0.25 mm) until overcorrection was reached. For each subject, lateral cephalograms and plaster casts were obtained before treatment (T1) and after 1 year (T2). A randomization list was created for the group assignment, with an allocation ratio of 1:1:1. The observer who performed all the measurements was blinded to group assignment. The study was single-blinded in regard to statistical analysis. RME was effective in the correction of maxillary deficiency. Class II patients treated with both types of RME showed no significant improvement of the anteroposterior relationship of the maxilla and the mandible at both skeletal and occlusal levels. The acrylic splint RME had significant effects on reducing the skeletal vertical dimension and the gonial angle. The orthopedic expansion did not affect the sagittal relationship of class II patients treated in the early mixed dentition when compared with the untreated control group. Additional studies with a larger sample are warranted to elucidate individual variations in dento-skeletal mandibular response to the maxillary expansion protocol in class-II-growing patients. ClinicalTrials.gov NCT03159962 .

Background This study cephalometrically compared the dentoskeletal and soft tissue changes consequent to one and three-premolar extraction protocols of class II subdivision malocclusion treatment. Methods A sample of 126 lateral cephalometric radiographs from 63 patients was selected and divided into two groups. Group 1 consisted of 31 type 1 class II subdivision malocclusion patients treated with asymmetric extractions of two maxillary premolars and one mandibular premolar on the class I side, with an initial mean age of 13.58 years. Group 2 consisted of 32 type 2 class II subdivision malocclusion patients treated with asymmetric extraction of one maxillary first premolar on the class II side, with an initial mean age of 13.98 years. t test was used for intergroup comparison at the pre- and posttreatment stages and to compare the treatment changes. Results Group 1 had greater maxillomandibular sagittal discrepancy reduction and greater maxillary first molar extrusion. Group 2 had mandibular incisor labial inclination and protrusion, and group 1 had mandibular incisor lingual inclination and retraction. Maxillary molar asymmetry increased in group 2, while mandibular molar asymmetry increased in group 1. Conclusions The treatment changes produced by these two class II subdivision protocols are different to adequately satisfy the different needs for types 1 and 2 class II subdivision malocclusions.

Background The aim of this study is to identify cephalometric pretreatment parameters for prediction of Class II improvement induced by rapid maxillary expansion. Methods Lateral cephalograms of 30 patients (mean age 8.3 ± 1.6 years old) showing Class II molar relationship and undergone to rapid maxillary expansion on the upper deciduous molars were traced before treatment, and molar relation changes were evaluated on dental casts before and after treatment. Overall treatment time lasted 10.2 ± 2 months. Good responders (18 subjects, 10 females and 8 males) showed improvement of at least 2.50 mm, and bad responders (12 subjects, 7 females and 5 males) showed no improvement, improvement less than 2.50 mm, or worsening of molar relationship after treatment. Student’s t test was used to assess significance of differences between groups, and discriminant analysis allowed identification of predictive pretreatment variables. Results Articular angle, superior gonial angle, and mandibular dimensions (Co-Gn, S-Ar, Ar-Go, Go-Me) showed significant differences in the comparison between groups. Mandibular length Co-Gn and superior gonial angle were selected as significant predictive variable for discrimination. Conclusions Patients with smaller mandibular length and more acute superior gonial angle are expected to have more chances to improve molar Class II after rapid maxillary expansion.

Several studies have shown soft tissue profile changes after orthodontic treatment in Class II Division 1 patients. However, a few studies have described factors influencing the soft tissue changes. The purpose of this study was to investigate the factors influencing the soft tissue profile changes following orthodontic treatment in Class II Division 1 patients. The subjects comprised 104 Thai patients age 8–16 years who presented Class II Division 1 malocclusions and were treated with different orthodontic modalities comprising cervical headgear, Class II traction and extraction of the four first premolars. The profile changes were evaluated from the lateral cephalograms before and after treatment by means of the X-Y coordinate system. Significant soft tissue profile changes were evaluated by paired t test at a 0.05 significance level. The correlations among significant soft tissue changes and independent variables comprising treatment modality, age, sex, pretreatment skeletal, dental and soft tissue morphology were evaluated by stepwise multiple regression analysis at a 0.05 significance level. The multiple regression analysis indicated that different treatment modalities, age, sex, pretreatment skeletal, dental and soft tissue morphology were related to the profile changes. The predictive power of these variables on the soft tissue profile changes ranged from 9.9 to 40.3 %. Prediction of the soft tissue profile changes following treatment of Class II Division 1 malocclusion from initial patient morphology, age, sex and types of treatment was complicated and required several variables to explain their variations. Upper lip change in horizontal direction could be found only at the stomion superius and was less predictable than those of the lower lip. Variations in upper lip retraction at the stomion superius were explained by types of treatment (R 2 = 0.099), whereas protrusion of the lower lip at the labrale inferius was correlated with initial inclination of the lower incisor (L1 to NB), jaw relation (ANB angle), lower lip thickness and sex (R 2 = 0.403). Prediction of chin protrusion at the soft tissue pogonion was also low predictable (R 2 = 0.190) depending upon sex, age and initial mandibular plane angle (SN-GoGn). Additionally, age and sex also had mainly effect on change of the soft tissue profile in the vertical direction.

Introduction The purpose of this study was to analyze the skeletal and dentoalveolar changes induced by the Fast-Back appliance followed by fixed appliances when compared with untreated Class II controls. Materials and methods The treated and untreated samples consisted of 27 subjects each (16 girls and 11 boys in the Fast-Back Group, FBG; 15 girls and 12 boys in the control Group, CG) with mean ages at the start of treatment of 13 years 3 months in the FBG and 13 years 2 months in the CG. Subjects of the FBG were treated during either the pubertal or postpubertal periods. Lateral cephalograms were analyzed at 2 observation periods: before distalization (T1) and after comprehensive orthodontic treatment appliance (T2). The T1-T2 changes in the FBG were contrasted with those in the CG by means of Mann-Whitney U test (p Results Treatment induced an average correction of molar relationship of 2.4 mm. The significant correction of the overjet (2.1 mm) was associated with a significant amount of lower incisor proclination (3.8 degrees). A significant extrusion of lower molars (1.8 mm) was recorded in the FBG. The FBG showed also a significant increase in total mandibular length (Co-Gn, 2.6 mm), a counterclockwise rotation of the palatal plane (1.4 degrees), an increase in anterior facial height (N-Me, 2.7 mm), and in mandibular ramus height (Co-Go, 2.6 mm). Conclusions The Fast-Back is an effective appliance for Class II correction during the pubertal or postpubertal periods.

Objectives To evaluate the clinical performance of the stainless steel crown Herbst (cHerbst) used as a single appliance for a single phase therapy. Materials and methods A total of 180 consecutive Class II patients were treated with cHerbst for one year and followed up one year after the end of treatment. Results Class I relationship was achieved in all 175 patients who finished the functional phase of treatment, 58 patients continued treatment with fixed appliances while 21 patients (12%) showed relapse. Seventy two patients (41.1%) obtained and maintained stable Class I relationship one year after treatment with the cHerbst appliance used as a single appliance. Altogether 46 episodes of appliance breakages were observed and most of them could be repaired at the chair side. Patients’ questionnaire revealed that in general the appliance was easy to tolerate and did not cause esthetic or functional problems. Conclusions The crown Herbst appliance is a viable therapeutical option in patients with Class II malocclusions and it is characterized by low complication rate along with good patient compliance.

Objectives The purpose of this retrospective prolective study is to evaluate soft tissue, dentoalveolar and skeletal vertical changes following conventional anchorage molar distalization therapy in adult patients. Materials and methods Forty-six patients (34 females, mean age 25 years 6 months; and 12 males, mean age 28 years 4 months) were recruited from 4 specialists Board Certified. All subjects underwent molar distalization therapy according different distalization mechanics. Cephalometric headfilms were available for all subjects before (T0) and at the end of comprehensive treatment (T1). The initial and final measurements and treatment changes were compared by means of a paired t-test or a paired Wilcoxon test. Results Mean total treatment time was 3 years 3 months ± 8 months. Maxillary first and second molars distalized 2.16 ± 0.84 mm and 2.01 ± 0.69 mm respectively, but also maintained a slight distal tipping of 1.45° (min 2.22°, max -6.45°) and 3.35° (min 0.47°, max -15.48°) at the end of treatment. Distal movement of maxillary first molar contributed 57.6% to molar correction, and 42.4% was due to a mesial movement of mandibular first molar (1.59 ± 0.46 mm). Dentoalveolar changes contributed to overjet correction; maxillary incisors retroclined 5.78° ± 3.17°, lower incisors proclined 7.49° ± 4.52° and occlusal plane rotated down and backward 2.32° ± 2.10°. A significant clockwise rotation of the mandible (1.97° ± 1.32°) and a significant increase in lower facial height (3.35 ± 1.48) mm were observed. Upper lip slightly retruded (-1.76 ± 1.70 mm) and lower lip protruded (0.96 ± 0.99 mm) but these changes had a negligible impact on clinical appearance. Conclusions Although maxillary molar distalization therapy can be performed in adult patients, significant proclination of the lower incisors, clockwise rotation of the occlusal plane and increase in vertical facial dimension should be expected. Nevertheless, in absence of maxillary third molars and in presence of mandibular third molars this procedure could be recommended.

Objective To compare the amount of upper molar rotation in subjects with Class II Division 1 malocclusion and subjects with normal occlusion in the intermediate and late mixed dentition phases. Materials and methods Dental cast measurements were performed in a sample of 120 Class II Division 1 subjects (CL2 group, 67 females and 53 males, mean age 9.4 ± 1.1 years), and in a sample of 58 Class I subjects (CL1 group, 34 females and 24 males, mean age 9.7 ± 1.2 years). Independent sample t tests were used for statistical comparisons (P Results The amount of upper molar rotation was significantly greater in CL2 group when compared with CL1 group as assessed by both the mesial and buccal molar cusp angles. No differences were found with regard to upper or lower arch depths, or upper intercanine width. CL2 group showed a significant deficiency in upper intermolar width along with a significant posterior transverse interarch discrepancy when compared with CL1 group. Conclusions Subjects with Class II malocclusion in the mixed dentition present with mesial upper molar rotation in about 84% of the cases. The correction of molar rotation may provide between 1 and 2 mm of gain in arch perimeter and of improvement in molar relationships per side in 5 out 6 Class II patients.

Objective To present a treatment protocol for improved stability with Herbst appliance treatment in Class II adult cases. Materials and methods Sixteen Class II adults were treated at the University of Hong Kong with two phase treatment. The treatment protocol which leads to good stability was presented. Results The protocol leading to stable correction of overjet, molar relationship and enhanced forward positioning of the mandible involved 12 months Herbst appliance treatment with stepwise advancement followed by fixed appliance. Conclusions The long term stability of Herbst appliance treatment is influenced by the treatment protocol employed. Based on the stability of the adult group in the present study, it is recommended to treat for 12 months in a step-wise manner for mandibular advancement with over correction.

Objective To evaluate the outcomes of functional jaw orthopedics (FJO) followed by fixed appliances in Class II patients showing cephalometric signs predictive of unfavorable responsiveness to orthopedic treatment. Materials and methods A total of 48 treated subjects (20 males, 28 females) with unfavorable Class II malocclusions were treated with FJO at the adolescent growth spurt, followed by fixed appliances. Treatment outcomes were compared with the growth changes in a matched control group of untreated subjects with “unfavorable” Class II malocclusions. Results A significant prevalence rate of successful outcome was recorded within the treated group (64.5%). When compared with the untreated controls, both the overall treated group and the successful treated subgroup revealed a significant reduction in maxillary growth and sagittal position, along with a significant enhancement in mandibular length, sagittal advancement of the mandible, and significant improvements in the maxillo-mandibular relationships. Both overjet and molar relation showed significant favorable changes in the treated group. Conclusions FJO at the pubertal spurt followed by fixed appliances is a viable therapeutical option in patients with “unfavorable” Class II malocclusions, although skeletal changes are of minor entity.

Background The use of three-dimensional (3D) surface imaging is becoming more popular and accepted in the fields of Medicine and Dentistry. The present study aims to develop a technique to automatically localise and quantify soft-tissue asymmetry in adults using 3D facial scans. This may be applied as a diagnostic tool to monitor growth and dynamic changes and to evaluate treatment outcomes. Methods 3D facial surface data were captured from 55 adults comprising 28 symmetrical faces and 27 asymmetrical faces using a 3dMDface system. A landmark-independent method, which compared the original and the mirrored 3D facial data, was developed to quantify the asymmetry. A Weibull distribution-based probabilistic model was generated from the root-mean-square (RMS) error data for the symmetrical group to designate a level of asymmetry which represented a normal range. Results Statistically significant (p

This study aimed to investigate the dental and skeletal variables associated with disturbances of craniofacial development in oral-breathing (OB) individuals and the probability that these variables are related to this condition. This is an observational retrospective case–control study of 1596 patients divided into three groups of age n1 5–12, n2 13–18, and n3 19–57 years. Radiographic, clinical, and models data were analyzed. The control group was consisted of nasal breathing (NB) individuals. Statistical analyses of the qualitative data were performed with x 2 test to identify associations, and odds ratio (OR) tests were performed for the variables that the chi-square test (x 2) identified an association. In the descriptive analysis of the data, we observed that the class II malocclusion was the most frequent in the total sample, but when divided by age group and mode of breathing, there is a random division of these variables. In n1 group, class II, (OR = 2.02) short and retruded mandible (SM and RM) (OR = 1.65 and1.89) were associated with OB and it was considered a risk factor. In n2 group, class II (OR = 1.73), SM (OR = 1.87) and increased lower anterior height (ILAFH) (OR = 1.84) seemed to be associated and to be risk factors for OB. In the n1 group, decreased lower anterior facial height (DLAFH) and brachycephalic facial pattern (BP) seemed to be associated with NB and a protective factor against oral breathing. This study showed that dental and skeletal factors are associated with OB in children, and it seems that it becomes more severe until adolescence. But adults showed no associations between OB and skeletal factors, only in dental variables, indicating that there is no cause–effect relationship between the dental and skeletal factors and OB. The treatment of nose breathing patient should be multidisciplinary, since OB remains even when dental and skeletal factors slow down.

Background The aim of this retrospective study was to identify which dental and/or cephalometric variables were predictors of long-term maxillary dental arch stability in patients treated with a transpalatal arch (TPA) during the mixed dentition phase followed by full fixed appliances in the permanent dentition. Methods Thirty-six patients, treated with TPA followed up by full fixed appliances, were divided into stable and relapse groups based on the long-term presence or not of relapse. Intercuspid, interpremolar and intermolar widths, arch length and perimeter, crowding, and upper incisor proclination were evaluated before treatment (T 0), post-TPA treatment (T 1), post-fixed appliance treatment (T 2), and a minimum of 3 years after full fixed appliances’ removal (T 3). A binary logistic regression was performed thereafter to evaluate the impact of the dental arch and cephalometric measurements at T 1 and the changes between T 0 and T 1 as predictive variables for relapse at T 3. Results The proposed model explained 42.7 % of the variance in treatment stability and correctly classified 72.2 % of the sample. Of the seven predictive variables, only upper anterior crowding (p = 0.029) was statistically significant. For every millimeter of decreased crowding at T 1 (after TPA treatment/before starting the fixed orthodontic treatment), there was an increase of 3.57 times in the odds of having stability. Conclusions The best predictor of relapse was maxillary crowding before treatment. The odds of relapse increase by 3.6 times for every millimeter of crowding at baseline.

Background The aim of this retrospective study was to cephalometrically evaluate the skeletal and dental effects of the transverse sagittal maxillary expander (TSME), for the correction of sagittal and transverse maxillary deficiency in class I, II, and III malocclusions. Methods The sample for this retrospective study included 45 patients (mean age, 8.4 years; 26 females, 19 males; 15 skeletal class I subjects, 15 skeletal class II subjects, and 15 skeletal class III subjects) with maxillary bilateral cross-bite. For each patient, a lateral cephalogram was obtained before treatment and at the end of the retention period. Changes in the groups during the observation period were calculated, compared, and statistically analyzed with a t-test. Results The cephalometric values before T0 and T1 showed significant changes. Conclusions The TSME can produce skeletal changes due to the transverse force and sagittal effects on the maxillary alveolar process. These modifications have benefic effects in classes I, II, and III. The data obtained in this study permit us to underline the fact that TSME can be used in all of the skeletal classes, with good vertical and sagittal results.

Background The objectives of this study were to check the reliability of the five angular and two linear parameters for sagittal maxillo-mandibular discrepancy and to compare and correlate angular parameters with the ANB angle, and the linear parameter with Wits analysis. Methods The pre-treatment and post-functional lateral cephalograms of 25 subjects (17 males, 8 females) with class II division 1 malocclusion treated with twin block functional appliance were selected. Five angular (ANB, β angle, APDI, YEN angle, W angle) and two linear (Wits analysis, App-Bpp) parameters were traced on both sets of cephalograms. Paired Student’s t-test, one-way ANOVA, post hoc test, and Karl Pearson correlation statistical analysis were performed. Results All the parameters considered in our study showed highly significant difference in pre-treatment and post-functional values, suggesting their reliability (p p p = 0.949). Conclusions All the parameters used in the study can be reliably used to assess anteroposterior skeletal discrepancy. Whenever limitations of the ANB angle and Wits analysis are foreseen, the W angle and App-Bpp, respectively, can be reliably used. The YEN angle may reliably predict the post-functional change with the use of twin block appliance.

Background Mesial protraction of mandibular posterior teeth requires increased anchorage to avoid undesired tooth movements. Orthodontic mini-implants have become a popular and successful way to increase skeletal anchorage in such cases. However, mini-implants may cause injury to adjacent teeth or anatomical structures and may lead to tissue inflammation. Induced ankylosed primary teeth have been used in the past as abutments for the protraction of the maxilla in cases of maxillary retrognathism. However, this technique has not been described in the literature for the protraction of mandibular molars. The aim of this paper is to present, through a case report, an alternative to mini-implant devices to maximize anchorage in the mandible by inducing ankylosis on a primary molar. Findings A 13-year-old female with class II right malocclusion, deep bite, and congenitally missing right second premolars was referred for orthodontic treatment. Treatment plan involved removal of the primary teeth and mesial protraction of the posterior. In the mandible, ankylosis was induced on the retained primary second molar by extraction, bisection, replantation of the mesial part after endodontic treatment, and bonding of a rigid splint. Ankylosis was diagnosed after 10 weeks and a closing T-loop sectional wire was inserted to move the permanent first molar mesially. At 6 months, the remaining space was closed using elastic chain on a rectangular stainless steel wire with tip-back bends, supported by class II elastics. Conclusions Induced ankylosis of primary teeth can be an alternative to orthodontic mini-implants in selected cases, with minimal risks and maximum biocompatibility.

Background There are controversial opinions about the effect of erupted second molars on distalization of the first molars. Most of the distalizing devices are anchored on the first molars, without including second molars; so, differences between sequentially distalize maxillary molars (second molar followed by the first molar) or distalize second and first molars together are not clear. The aim of the study was to compare sequential versus simultaneous molar distalization therapy with erupted second molar using two different modified Pendulum appliances followed by fixed appliances. Methods The treatment sample consisted of 35 class II malocclusion subjects, divided in two groups: group 1 consisted of 24 patients (13 males and 11 females) with a mean pre-treatment age of 12.9 years, treated with the Segmented Pendulum (SP) and fixed appliances; group 2 consisted of 11 patients (6 males and 5 females) with a mean pre-treatment age of 13.2 years, treated with the Quad Pendulum (QP) and fixed appliances. Lateral cephalograms were obtained before treatment (T1), at the end of distalization (T2), and at the end of orthodontic fixed appliance therapy (T3). A Student t test was used to identify significant between-group differences between T1 to T2, T2 to T3, and T1 to T3. Results QP and SP were equally effective in distalizing maxillary molars (3.5 and 4 mm, respectively) between T1 and T2; however, the maxillary first molar showed less distal tipping (4.6° vs. 9.6°) and more extrusion (1.1 vs. 0.2 mm) in the QP group than in the SP group, as well as the vertical facial dimension, which increased more in the QP group (1.2°) than in the SP group (0.7°). At T3, the QP group maintained greater increase in lower anterior facial height and molar extrusion and decrease in overbite than the SP group. Conclusion Quad Pendulum seems to have greater increase in vertical dimension and molar extrusion than the Segmented Pendulum.

Background Extraction has now been accepted widely in various malocclusions including Angle's class II division 1. However, the levels of scientific evidence in orthodontic treatment planning have been weak, and it is unlikely to systematically provide a rationale and consistent basis in decisions of extraction. This study was retrospectively designed to investigate the initial morphologic characteristics of class II division 1 subjects involving four different extraction strategies, to determine the relevant influential factors when choosing extraction strategies with the most commonly used mechanics and the principle of simplicity in orthodontic treatment based on cases diagnosed and treated by an experienced orthodontist. Methods One hundred and ten samples of Angle's class II division 1 malocclusion with good facial and occlusal outcomes after orthodontic treatment were selected and divided into four groups according to different extraction patterns. For each case, pretreatment models and the lateral radiographs were analyzed. Significant variables of models and craniofacial structures of each group were identified by comparing the measurements using one-way analysis of variance (ANOVA) at a significance level of P Results Molar relationship, lower anterior crowding, anterior Bolton index, and anterior overjet measured from models, as well as ANS-Xi-Pm, NBa-PtGn, Li-NsPog', U1-NPog and L1-NPog measured from lateral radiographs were found to be statistically significant. Binary logistic regression analysis revealed that lower anterior crowding, molar relationship, and growth pattern were the three most relevant influential factors with a declining impact contributing to the extraction decisions for Angle's class II division 1 malocclusions. Conclusions Angle's class II division 1 malocclusions exhibit various morphological characteristics. Orthodontists should comprehensively consider the reciprocal impact of multiple factors when choosing different extraction strategies for Angle's class II division 1 malocclusions.

Background The objective of this study was to evaluate the treatment effects of Forsus™ Fatigue Resistant Device (FRD; 3M Unitek, Monrovia, CA, USA) in growing patients with Class II non-extraction malocclusions. Methods A retrospective sample of 24 class II patients treated consecutively with the FRD followed by comprehensive orthodontic treatment was compared to a sample of untreated control subjects from the Bolton Brush Study who was matched in age, sex, and craniofacial morphology. Lateral cephalometric radiographs were taken before treatment (T1) and after removal of fixed appliances (T2). Growth changes were subtracted from the treatment changes to obtain the treatment effects of the appliance. Data were analyzed using ANOVA and a match paired t test. Results Significant differences were found between the treated and control groups for 12 of the 29 measured variables (Co-Gn minus Co-Apt, Wits, Is-OLp, Ii-OLp, overjet, Mi-OLp, molar relationship, overbite, Mic-ML, SNA, ANB, and Ii-ML). With 27.8 months of treatment, all patients were corrected to a class I dental arch relationship. Overjet and molar relationships were improved by an average of 4.7 and 3.1 mm, respectively. This was contributed by a 1.2 mm of restraint in forward maxillary growth, 0.7 mm of forward movement of the mandible, 1.5 mm of backward movement of the maxillary incisors, 1.3 mm forward movement of the mandibular incisors, 0.5 mm backward movement of the maxillary molars, and 1.3 mm of forward movement of the mandibular molars. The overbite was decreased by 2 mm with no significant change in the occlusal, palatal, or mandibular plane. Individual variations in response to the FRD treatment were large for most of the parameters tested. Significant differences in treatment changes between male and female subjects were found only in a few parameters measured. Conclusions These results demonstrate that significant overjet and overbite corrections can be obtained with the Forsus FRD in conjunction with comprehensive orthodontic treatment.

Background The inclination of the occlusal plane (OP) is related to facial types and experiences physiological growth-related changes. The aims of this research were to determine if there were any differences in the inclination of OP in subjects with three types of skeletal malocclusion and to investigate the characteristics and differences of functional occlusal plane (FOP) compared to bisected occlusal plane (BOP). Methods A sample of 90 Caucasians patients was skeletal-classified into three (n = 30), and pre- and post-treatment cephalograms were digitized. Six linear and 8 angular cephalometric measurements were selected. The changes of OP inclination within each group and the differences among the three groups pre- and post-treatment were compared with paired t test and ANOVA test, respectively. The comparison and correlation between BOP and FOP were analyzed with paired t test and coefficient of correlation, respectively. Results The BOP angle increased in all of the three groups but only had statistically significant differences in skeletal class II patients in a mean of 1.51° (p < 0.05). The FOP-SN angle showed stability (p > 0.05) in all three groups. The inclination of FOP was closely related to that of BOP (p < 0.001) but revealed discrepancies in each group. Conclusions BOP and FOP were statistically significantly steeper in class II subjects compared to the other two groups both before and after treatment. The BOP angle statistically significantly increased by 1.51° in skeletal class II patients. BOP was a more reproducible reference plane compared to FOP during cephalometric tracing process, while FOP showed stability in orthodontically treated patients with all three skeletal patterns.

Background The study aims to associate serum insulin-like growth factor-1 (IGF-1) levels with cervical maturation stages (CS) 3, 4, and 5 on lateral cephalogram in male subjects and to find out peak serum IGF-1 levels among these three stages. Methods The study was conducted on 45 male subjects who were at skeletal maturation stage CS-3, CS-4, and CS-5. Subjects were selected using simple random sampling technique. Serum IGF-1 levels were estimated from blood samples using chemiluminescence immunoassay (CLIA) method. CS was evaluated using a six-stage method of evaluating the cervical vertebrae. Mean IGF-1 levels between the stages were compared by analysis of variance (ANOVA) test. Results One-way ANOVA showed highly significant differences between all cervical stages with p value

Background The aim of the present study was to assess the muscular variations at the electromyography (EMG) level for the anterior temporalis muscles and masseter muscles during treatment with Occlus-o-Guide® and Andresen activator appliances. Methods Eighty-two patients (35 males and 47 females) aged between 8 and 12 years (mean age, 10.5 ± 0.8 years) participated in the study. Fifty patients underwent treatment with an Occlus-o-Guide® and 32 patients with an Andresen activator. All patients underwent EMG examination using a Freely EMG (De Gotzen, Legnano, Italy) and surface bipolar electrodes when the appliances were worn for the first time (T0), and after 6 months (T1) and after 12 months (T2) of appliance use. Results Statistical analysis showed that both at T0 and T2, the percent overlapping coefficient (POC) of the anterior temporalis muscles was not statistically different between the appliance groups. At T0, the POC of the masseter muscles was significantly lower for the Andresen appliance as compared to the Occlus-o-Guide® (p = 0.02), while at T2 this significance was lost. Conclusions At insertion of an appliance, all patients show neuromuscular balance that does not correspond to orthognathic occlusion. Both appliances work by creating muscular imbalance. With the appliances in situ, EMG responses were generally analogous for the Occlus-o-Guide® and the Andresen activator; however, the imbalance was greater and the recovery of the orthological muscular balance was slower in patients under treatment with the Andresen activator as compared to those with the Occlus-o-Guide®.

Background The aim of present study was to determine the prevalence of malocclusions, oral habits and the need for orthodontic treatment in a sample of 7- to 15-year-old Albanese schoolchildren. Methods The final sample comprised 2,617 subjects (1,257 males and 1,360 females), all orthodontically untreated. Occlusal relationship and the functional analysis were recorded for all subjects. The prevalence rates for the dental health component of the index of orthodontic treatment need (IOTN) were calculated. Comparisons between genders were performed for the prevalence of malocclusions, oral habits and IOTN grades (chi-square tests). Results Class I, class II and class III malocclusions and asymmetries were observed in 40.4%, 29.2%, 3.2% and 27.1% of the sample, respectively. There were 2,108 subjects (80.6%) that showed oral habits, with females (82.1%) presenting with a greater prevalence rate than males (78.9%). The objective need for orthodontic treatment (grades 4 and 5 of IOTN) was registered in 1,077 subjects (41.2%). This prevalence rate is higher than those reported for other European countries. No significant differences between genders were found for the IOTN grades. Conclusions The findings of the present study revealed the need to improve public health plans for orthodontic prevention and screening and to organise the resources in this area in Albania.

Background Whether skeletal effects are obtained by functional appliances in class II subjects is still controversial. In this regard, most of the available studies did not clearly identify the growth phases (i.e. pubertal or not) of the treated patients. This retrospective controlled study aimed at evaluating the skeletal and dental changes in class II subjects produced by the functional regulator (FR)-2 treatment during the pre-pubertal growth phase. Methods The data were derived from records obtained at a university dental clinic. A total of 17 treated subjects and a total of 17 untreated controls, all pre-pubertal, matched for malocclusion, age (8.8 ± 1.5 years) and sex (18 females, 16 males), were included. The overall observational period was 1.6 ± 0.8 years for both groups. Results Only minor skeletal changes with very little clinical relevance were seen after the observational period. Most of the changes produced by the FR-2 treatment were at the dental level including palatal tipping of the maxillary incisors and slight proclination of the mandibular incisors, both accounting for the noteworthy overjet reduction. Conclusions The present study has shown that functional treatment of class II malocclusion by FR-2 appliance during the pre-pubertal growth phase is limited to modification at the dental level.

A new cast-metal-type splint expander was used to treat severe maxillary constriction. This new appliance has the same advantages of a rapid expander on acrylic splints, compared to a Haas or to a banded expander. Furthermore, it is characterized by greater respect for the gingival tissue, both during the therapy and immediately after the removal of the expander. It is also more comfortable for the patient, so that it is possible to maintain the expander in the mouth for several months without gingival suffering. This appliance is very versatile and well indicated for permanent, mixed and deciduous dentitions.

Objectives The aim of this study was the evaluation of the neuromuscular response to treatment according to diagnostic phases, as a follow-up of patients under surgical orthodontic treatment. The patient sample was subdivided into sub-samples, according to clinical characteristics. Materials and methods All of the patients who underwent orthognathic surgery in the Department of Orthodontics (University of Milan) were subjected to periodic electromyographic evaluation of the masticatory muscles (masseter and anterior temporal muscles), and to electrokinesiographic evaluation of the mandibular movements. The patient sample comprised 80 patients (37 males; and 43 females) at the end of growth. The electromyographic instruments used in the study included a Freely and a K6-I electromyography. Statistical evaluation was carried out with the Student's t-tests for independent samples. Results There are many differences between the skeletal Class II and skeletal Class III patients that are shown through the analysis of these data obtained. In the beginning phases of the treatment the muscular activities were higher in the Class II patients than in the Class III patients. Nevertheless this difference was reversed at the end of the treatment. A similar difference could be found in the mandibular kinesiology, in fact the maximum mandibular opening movement was greater in the skeletal Class II patients than in the skeletal Class III patients at the beginning of the treatment. At the end of the treatment this difference was lost. At the beginning of the treatment the Class II patients showed a greater protrusive movement of the mandibular than the Class III patients. At the end the treatment however this gap was reduced without being reversed. Conclusions Functional evaluation in patients in surgical orthodontic therapy is an important element in the diagnostic–therapeutic recordings, so as to reduce as much as possible any incorrect neuromuscular activity that can result in relapse.

This study analysed the ability of orthodontists and laypeople to discriminate mandibular stepwise advancements.Four pictures (in duplicate) were taken of a male patient with Class II malocclusion and mandibular deficiency with the mandible positioned in habitual maximum intercuspation (HMI) and with stepwise advancements of 2mm, 4mm and 6mm. These images were examined by orthodontists (n=30) and laypeople (n=30). The Wilcoxon signed-rank test was used to evaluate intra-examiner agreement. Intra-examiner ability to discriminate stepwise mandibular advancements was examined by Friedman's test. A Mann-Whitney's test was carried out to analyse score difference between orthodontists and laypeople. Type I error (alpha) was set as 5% for all statistical tests.We observed a satisfactory to excellent level of methodological reliability. While laypeople were able to notice mandibular advancements ≥4 mm (p0.05), orthodontists were able to observe mandibular advancements ≥2 mm (p0.05). The orthodontists were more critical than laypeople with regard to the facial profile evaluation when facial convexity increased (p0.001), but no significant difference was observed when the sagittal maxillo-mandibular relationship approached normality (p0.05).Considering that the mean sagittal mandibular growth due to the use of functional orthopaedic appliances is reported in the literature as 2mm, it seems that laypeople may not able to discriminate this amount of change in facial-profile attractiveness.

The aim of this paper is to analyze the evolution that the Herbst appliance has experienced in the last 30 years. In particular the different designs proposed for the Herbst appliance are examined and the related differences in clinical management, indications, and treatment effects are also illustrated. The two major challenges in the clinical management of the Herbst appliance are represented by the choice of the type of stabilization and by the control of the proclination of the lower incisors. The use of acrylic splints presents a set of relevant advantages: the construction technique is simple, the appliance can be worn easily by the patients, and the height of the splint can be adjusted to the growth pattern. Moreover, the acrylic splint Herbst can be used to reposition the mandible in cases with temporomandibular disorders. As for the proclination of the lower incisors, an accurate assessment of the neuromuscular pattern of the individual patient before treatment can provide the clinician with reliable criteria to evaluate the risk for incisor proclination during Herbst therapy.