1. Epistatic interactions implicating dopaminergic genes in bulimia nervosa (BN): relationships to eating- and personality-related psychopathology.
- Author
-
Thaler L, Groleau P, Badawi G, Sycz L, Zeramdini N, Too A, Israel M, Joober R, Bruce KR, and Steiger H
- Subjects
- Adult, Body Mass Index, Bulimia Nervosa complications, Bulimia Nervosa psychology, Female, Genetic Predisposition to Disease genetics, Genetic Predisposition to Disease psychology, Genotype, Humans, Personality Disorders complications, Personality Disorders psychology, Personality Inventory statistics & numerical data, Polymorphism, Genetic, Psychiatric Status Rating Scales statistics & numerical data, Self-Injurious Behavior genetics, Bulimia Nervosa genetics, Catechol O-Methyltransferase genetics, Dopamine Plasma Membrane Transport Proteins genetics, Epistasis, Genetic genetics, Personality Disorders genetics, Receptors, Dopamine D2 genetics, Receptors, Dopamine D4 genetics
- Abstract
We explored the influence of interactions between polymorphisms acting upon postsynaptic receptors (DRD2 TaqA1 rs1800497 and DRD4 7R) and dopamine regulators (COMT rs4680 and DAT1) on the expression of eating symptoms and personality traits in women with bulimia-spectrum eating disorders. We had 269 bulimic women provide blood for genetic assays, and measured eating-disorder symptoms and psychopathological traits using structured interviews and self-report questionnaires. We observed two epistatic interactions on symptom indices: interactions (in predicted directions) of DRD2 by DAT were seen on Body Mass Index (p=.023), and of DRD4 by COMT on self-harming behaviors (p=.014)--with genetic effects that would correspond to reduced dopamine transmission coinciding with more-pathological scores. Our findings suggest that genes acting in the dopamine system interact to influence both eating-related and personality psychopathology, with the result that lower levels of dopamine neuro-transmission correspond to increased psychopathology and body mass in women with bulimia-spectrum disorders. We discuss the implications of our observations., (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Published
- 2012
- Full Text
- View/download PDF