Search

To explore BNP, LVEDD, and LVEF levels in elderly patients with heart failure Relationship with heart function. Select 150 elderly heart failure patients who were treated in our hospital from March 2019 to December 2020 as the research objects, and divided them into A according to their BNP level (BNP level <94 pg/mL, 43 cases), B (BNP level 94~349.9 pg/mL, 40 cases), C (BNP level 350~988.9 pg/mL, 44 cases), D (BNP level ≥ 989 pg/mL, 23 cases) 4 groups, Compare 4 groups of patients with LVEDD, LVEF levels, blood homocysteine (Homocysteine, HCY) levels, compare 4 groups of patients with different cardiac function classification ratios, compare the incidence of adverse cardiac events in 4 groups of patients followed up for 2 months, and finally analyze BNP, LVEDD and LVEF are correlated with the heart function classification of patients with heart failure. LVEDD and HCY of the four groups A, B, C, and D showed an increasing trend, while the LVEF showed a decreasing trend. The levels of LVEDD and HCY were significantly higher than those in groups A and B (P<0.05). The levels of LVEF in groups C and D were significantly lower than those in groups A and B (P<0.05); patients in groups A, B, C, and D Cardiac function classification gradually worsened, 70 patients in group A were grade I, 27 patients were in grade II, 60 patients in group B were grade II, 29 patients were in grade III, 68 patients in group C were grade III, 20 patients were in grade IV, and 3 patients in group D were grade III. 43 cases of grade IV, the difference in cardiac function classification between the groups was statistically significant (P<0.05); the incidence of adverse cardiac events in the four groups of patients A, B, C, and D were 4.12 %, 11.24 %, 26.14 % and 43.48 %, respectively. The incidence of adverse events gradually increased, and the difference was statistically significant (P<0.05); BNP, LVEDD and cardiac function classification were positively correlated (r=0.878, 0.564, P<0.05), LVEF and cardiac function classification were negative correlation (r=-0.781, P<0.05). BNP, LVEDD and LVEF can be used as heart failure assessment indicators, which can evaluate the heart function and prognosis of patients with heart failure. [ABSTRACT FROM AUTHOR]

Objective: To explore the evaluation value of CT quantitative analysis of blood perfusion changes before and after intervention for cardiovascular disease. Methods: From February 2018 to November 2020, 95 cases of patients with coronary heart disease who were diagnosed and treated in our hospital were selected as the research objects. All patients were treated with percutaneous coronary intervention, and CT quantification were performed 1d before intervention and 1 month after the intervention with ultrasound examination, followed-up of coronary artery restenosis 6 months after intervention and conducted correlation analysis. Results: All patients were successfully completed the interventional treatment, and there were no serious complications occurred during the interventional period. The left ventricular ejection fraction (EF) and left ventricular short-axis shortening rate (FS) in the 95 patients 1 month after intervention were higher than those of 1 day before intervention (P<0.05), and the the difference in the left ventricular isovolumic relaxation time compared before and after intervention (iso-volumicrelaxationtime, IVRT) were not statistically significant (P>0.05). The myocardial blood flow (MBF) and myocardial blood volume (MBV) of 95 patients at 1 month after intervention were higher than 1 day before intervention (P<0.05), and time to peak (TTP) were lower than 1 day before intervention (P<0.05). Followed-up 6 months after intervention, 14 cases of coronary artery restenosis, restenosis rate 14.7 %, of which 12 cases were moderate stenosis, 2 cases were severe stenosis; Pearson analysis showed that MBF, MBV, TTP at 1 day before intervention of coronary heart disease patients were correlation to the FS and EF (P<0.05); Logistic regression analysis shows that MBF, MBV, TTP, FS, EF were important factors that affected the rate of restenosis in patients with coronary heart disease after intervention (P<0.05). Conclusion: The application of CT quantitative analysis before and after intervention of coronary heart disease can effectively reflect the changes of blood flow perfusion, and are related to the patient's cardiac function, and can also effectively predict the occurrence of coronary artery restenosis in patients with interventional follow-up. [ABSTRACT FROM AUTHOR]

Objective: To study the effects of SGLT2 inhibitors on blood glucose, blood uric acid levels and heart function in patients with type 2 diabetes. Methods: A total of 106 patients with type 2 diabetes combined with stable cardiac insufficiency admitted to our hospital from January 2019 to June 2020 were selected as the research objects. The patients were divided into two groups by random number table method. All patients were given diet control and exercise therapy for type 2 diabetes, and symptomatic drug therapy for cardiac insufficiency. Control group was additively given metformin, and observation group was additively given the SGLT2 inhibitordagliazin. Blood glucose, blood uric acid, BNP level, heart function and quality of life in 2 groups were compared. Results: There were no significant differences in the levels of PBG, FBG and HBAIC in 2 groups before treatment（P>0.05). After treatment, the above indexes in 2 groups were significantly decreased, and the observation group was significantly lower than the control group（P<0.05). There was no significant difference in UA and BNP levels between 2 groups before treatment（P>0.05). After treatment, the above indexes in 2 groups were significantly decreased, and the observation group was significantly lower than the control group（P<0.05). Before treatment, there was no statistical difference in LVEF and LVEDD levels between the two groups（P>0.05). After treatment, LVEF level in the observation group was significantly increased while LVEDD level was significantly decreased, and there was a statistical difference between the two groups（P<0.05). However, there was no statistical difference between the control group before and after treatment（P>0.05). There was no statistical difference in the SF-36 score between the two groups before treatment（P>0.05）, but after treatment, the SF-36 score of the two groups was significantly increased, and the observation group was significantly higher than the control group（P<0.05). There was no statistical difference in the incidence of adverse reactions between the two groups（P>0.05). Conclusion: Daglixin can significantly improve the levels of blood glucose and uric acid in patients with type 2 diabetes mellitus complicated with stable cardiac insufficiency, and can also improve the cardiac function of patients, which is worthy of clinical reference. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To explore the curative effect of sacubitril and valsartan sodium tablets in the treatment of patients with chronic heart failure (CHF) in plateau areas and their effects on neuroendocrine hormones and cardiac function. Methods: March 2017 2 109 cases of CHF patients in our hospital received 019 June period. According to the random number table method, the patients were randomly divided into a control group (n=54) and a study group (n=55). The patients in the control group were treated with valsartan, and the patients in the study group were treated with sacubitril and valsartan sodium tablets., Compare the efficacy, neuroendocrine hormone indicators [norepinephrine (NA), aldosterone (ALD), angiotensin II (Ang II)] and cardiac function indicators [hypersensitive cardiac troponin T (hs-cTnT)] between the two groups of patients, N-terminal pro-brain natriuretic peptide (NT-proBNP), left atrial diameter (LAD), left ventricular end diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF)]. The occurrence of adverse cardiovascular events in the two groups of patients was recorded. Results: The total effective rate of patients in the study group was 90.91% (50/55) after 12 weeks of treatment, which was significantly higher than the 75.93% (41/54) of patients in the control group (P<0.05). ALD, NA and AngⅡ decreased after 12 weeks of treatment in the two groups, and the study group was lower than the control group (P<0.05). After 12 weeks of treatment, hs-cTnT, NT-proBNP, LVEDD, LAD decreased in the two groups, and the study group was lower than the control group (P<0.05); LVEF increased, and the study group was higher than the control group (P<0.05). There was no difference in the incidence of adverse cardiovascular events between the two groups (P>0.05). Conclusion: Sacubitril and Valsartan Sodium Tablets has significant curative effect in the treatment of CHF patients in plateau areas. It can effectively improve neuroendocrine hormone levels and cardiac function without increasing the incidence of cardiovascular adverse events. It has high clinical application value. [ABSTRACT FROM AUTHOR]

Objective: To explore the therapeutic effect and mechanism of Dalbergin (DAL) on myocardial ischemia/reperfusion (MI/R) injury in mice. Methods: Adult male C57BL/6J mice were randomly divided into sham operation group (Sham), model group (MI/R), diltiazem group (Diltiazem) and DAL low, medium and high dose groups (10, 30, 90). mg/kg/d), 10 animals per group. The mouse left anterior descending coronary artery (LAD) was ligated, ischemia for 30 minutes, and reperfusion for 1 hour to establish a mouse MI/R injury model. From the first day after the operation, mice in Sham group and MI/R group were given an equal volume of normal saline, and mice in Diltiazem group and DAL group were given the corresponding liquid once a day for 7 consecutive days. After the administration, the activity of creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the serum of mice were detected. ) Content; detection of superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in mouse myocardial tissue; hematoxylin-eosin staining (HE) detection of myocardial injury pathology; Western Blot detection of Akt and P in myocardial tissue -Akt protein level expression changes; ultrasound detection of left ventricular end diastolic diameter (ESD), left ventricular end diastolic volume (EDV), ejection fraction (EF) and short axis shortening rate (FS). Results: DAL can reduce CK-MB, LDH activity and TNF-α, IL-6 content in mouse serum; increase SOD activity in mouse myocardial tissue and reduce MDA production; increase p-Akt protein level expression and reduce myocardial Histopathological damage improves heart function. Conclusion: DAL can increase the phosphorylation of Akt to promote the survival of cardiomyocytes, reduce the pathological damage of myocardial tissue, and then inhibit MI/R injury in mice, improve cardiac function, and ultimately play a role in myocardial therapy. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of Shuxuening injection combined with Danshen dropping pill on blood lipid and heart function in patients with acute coronary syndrome (ACS). Methods: 90 patients with ACS who were admitted to our hospital from February 2015 to December 2019 were selected, patients were randomly divided into the control group (n=45, routine basic treatment) and the study group (n=45, treatment of increasing Shuxuening injection combined with Danshen dropping pill) according to the digital table method. The curative effect, blood lipid, cardiac function and adverse reactions of the two groups were compared. Results: The total effective rate of the study group at 2 courses after treatment was 91.11% (41/45), which was higher than 73.33% (33/45) of the control group (P<0.05). The total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) of the two groups at 2 courses after treatment were lower than those before treatment, and the study group was lower than the control group (P<0.05). The high-density lipoprotein cholesterol (HDL-C) was higher than that before treatment, and the study group was higher than the control group (P<0.05). The left ventricular ejection fraction (LVEF), cardiac index (CI) and cardiac output (CO) of the two groups at 2 courses after treatment were higher than those before treatment, and the study group was higher than the control group (P<0.05), and the left ventricular end diastolic diameter (LVEDD) was lower than before treatment, and the study group was lower the control group (P<0.05). There was no significant difference in adverse reactions between the two groups (P>0.05). Conclusions: Shuxuening injection combined with Danshen dropping pill is effective in the treatment of ACS. It can effectively improve the blood lipid and heart function of the patients without increasing the incidence of adverse reactions. It is safe and reliable. [ABSTRACT FROM AUTHOR]

Objective: To compare the effect of primary PCI and delayed PCI on the heart function of patients with ST-segment elevation myocardial infarction(STEMI) by thoracic impedance method for testing cardiac output. Methods: 114 patients with STEMI were selected in the No 1 Hospital of Naval Force of Southern Theater Command of PLA from January 2016 to June 2018, they were divided into the primary PCI group(n=48), delayed PCI group(n=40) and control group without receiving any coronary artery reperfusion(n=26). The stroke volume(SV), cardiac index(CI), cardiac contractility index(CTI), ejection fraction(EF) were measured at 3 days and 6 months after therapy were detected by using thoracic impedance method, and the rehospitalization due to heart failure events in each group in 6 months were evaluated. Results: At 6 months after therapy, the SV, CI, CTI, EF were higher in the primary PCI group and delayed PCI groupthan these in control group, and SV, CTI, EF in primary PCI group were higher than these in delayed PCI group(P<0.05). The rehospitalization rate due to heart failure in primary PCI group and delayed PCI group were remarkably lower than these of control group(P<0.05). Conclusions: Both primary and delayed PCI can improve the heart function in medium and long term in patiens of STEMI, and the primary PCI is more effective. [ABSTRACT FROM AUTHOR]

Objective: To explore the clinical value of cardiac color Doppler ultrasound in evaluating cardiac function in patients with hypertensive left ventricular hypertrophy (LVH) combined with left ventricular failure, and to analyze the correlation between echocardiographic parameters and New York Heart Association (NYHA) classification. Methods: 127 patients with hypertensive LVH combined with left ventricular faiure who were admitted to our hospital from May 2017 to May 2018 were selected as observation group They were divided into NYHA class II group (41 cases), class III group (47 cases) and class IV group (39 cases) according to NYHA classification. Another 100 healthy volunteers were selected as control group. All subjects received cardiac color Doppler ultrasound to obtain relevant pararneters [left atrial dimension (LAD), left ventricular endsystolic dimesion (LVEDD), left ventricular endsystolic dimension (LVESD), left ventricular fractional shortening (LVFS), left ventricular posterior wall thickness(LVPWI), interventricular septal thickness (IVST), left ventricular ejection fraction (LVEF), maximum filling velocity ratio ofleft ventricular early diastolic filling peak to late diastolic filling peak (E/A) ratio, Tei index]. The correlation between cardiac color Doppler ultrasound parameters and NYHA classification was analised. Results: The LAD, LVEDD, LVESD, LVPWf, IVST and Tei index of the observation group were higher than those of the control group (P<0.05), and the LVFS, LVEF and E/A ratio were lower than those of the control group (P<0.05). Tei index increased with the increase of NYHA classification (P<0.05). Spearman rank correlation analysis showed that Tei index was positively correlated with NYHA classification (rs =0.398, P<0.05). LVFS, LVEF, E/A ratio were negatively correlated with NYHA classification (rs=0.285, -0.442, -0.305; P<0.05). Conclusion: The patients with hypertension LVH combined with left ventncular failure have significant left ventncular hypertrophy and left ventncular dysfunction. Cardiac color Doppler ultrasound can accurately assess the cardiac function and severity of Hypertension LVH patients with left ventncular failure, and some parameters related to color Doppler echocardiographyare related to NYHA classification. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical efficacy of L-carnitine in the treatment of elderly patients with chronic heart failure and its effects on vasoactive molecules and cardiac function. Methods: 120 elderly patients with chronic heart failure admitted in our hospital from June 2017 to June 2018 were randomly divided into the observation group and the control group. The control group received routine treatment, while the observation group was given L-carnitine on the basis of routine treatment. The clinical efficacy, angiotensin II (Ang II), aldosterone (ALD), nitric oxide (NO), endothelin-1 (ET-1), left ventricular ejection fraction (LVEF), left ventricular end systolic diameter (LVESD) and left ventricular end diastolic diameter (LVEDD) of the two groups were compared.Before treatment, the levels of SV, CO, CI, VE, VA and VE / VA in the two groups were similar, with no significant difference (P>0.05). Thetotal effective rate of the observation group was 91.67%, which was significantly higher than that of the control group (65%) (P<0.05). Results: Before treatment, there was no significant difference in LVEF, LVESD and LVEDD between the two groups (P>0.05). After treatment, the LVEF of the two groups was higher than before treatment, and the LVEF of the observation group was higher than that of the control group (P<0.05). After treatment, the LVESD and LVEDD of the two groups were lower than those before the treatment, and the LVESD and LVEDD in the observation group were lower than those of the control group, and the difference was statistically significant (P<0.05). Before treatment, there was no significant difference in the levels of Ang II, ALD, NO and ET-1 between the two groups (P>0.05). After treatment, the Ang II, ALD and ET-1 of the two groups were lower than those before the treatment, and the Ang II, ALD and ET-1 in the observation group were lower than those of the control group, and the difference was statistically significant (P<0.05). After treatment,the NO of the two groups was higher than before treatment, and the NO of the observation group was higher than that of the control group, with a statistically significant difference (P<0.05). No obvious adverse reactions were observed in the two groups during treatment. Conclusion: L-carnitine is effective in the treatment of elderly patients with chronic heart failure, and can effectively improve the level of vasoactive molecules and cardiac function, safe and reliable. [ABSTRACT FROM AUTHOR]

Objective: To investigate the value of tissue Doppler Tei index in evaluating fetal heart function in pregnant women with gestational diabetes mellitus (GDM) and the relationship between maternal and child prognosis and blood glucose control. Methods: 80 GDM pregnant women who underwent prenatal examination in our hospital from January 2017 to June 2018 were enrolled. According to the glycemic control, they were divided into good group (48 cases) and bad group (32 cases). In addition, 50 healthy pregnant women who were prenatally examined in our hospital and produced in our hospital were selected as the control group. The isometric contraction time (ICT), isovolumic relaxation time (IRT), ejection time (ET), Tei index, pregnancy outcome, and neonatal complications were compared in the three groups. Results: The ET of the bad group was less than that of the good group and the control group, the Tei index was higher than that of the good group and the control group, the difference was statistically significant (P<0.05). The incidence of macrosomia, premature delivery, polyhydramnios and fetal distress in the bad group were high than those in the good group and the control group, the difference was statistically significant (P <0.05). The incidence of neonatal hypoglycemia and hyperbilirubinemia in the bad group were higher than those in the good group and the control group, and the difference was statistically significant (P<0.05). Conclusion: Tissue Doppler Tei index has a high evaluation value for fetal heart function in GDM pregnant women. It can detect fetal cardiac dysfunction sensitively. Poor blood glucose control can significantly increase the incidence of adverse pregnancy outcomes and neonatal complications. [ABSTRACT FROM AUTHOR]

Objective: To study the effect of GATA4 gene H435Y mutation on the heart function of mice and its possible mechanisms. Methods: Our research included in 2 groups: Wild type (WT) mice group and Gata4 H435Y mutant(Gata4 H435Y) mice group, 6 mice in each group. The heart function and the ratio of heart weight to body weight (HW/BW) were compared between 2 groups; the myocardial morphology was observed by Masson staining; the mRNA and protein expressions of GATA4, Sox9, Scleraxis, Tenascin and Aggrecan were determined by RT-PCR and Western blot analysis. Results: Compared with the WT mice, GATA4 H435Y mice group showed decreased LVEF, LV fraction shortening and increased left ventricular internal diameter at end-systole (LVESD)(P<0.05). The BWand ratio of HW/BWof GATA4 H435Y mice were obviously lower (P<0.05), the heart weight showed no significant difference between 2 groups (P>0.05). Masson staining showed that there was no significant difference in the myocardial fibers between the two groups, but the collagen fibers of myocardiumin WT group were deeper. The mRNA and protein expressions of GATA4, Sox9 and Scleraxis were decreased in GATA4 H435Y mice (P<0.05), Tenascin and Aggrecan showed no significant difference between 2 groups(P>0. 05). Conclusion: GATA4 gene H435Y mutation may affect the expression of extracellular matrix genes in cardiac muscle by reducing the expression of GATA4 and downstreamgenes, thereby impairing the cardiac function of mice. [ABSTRACT FROM AUTHOR]

Objective: To explore the efficacy of low dose dopamine combined with milrinone in the treatment of patients with intractable heart failure and its influence on heart function. Methods: A total of 160 patients with intractable heart failure,who were treated in First Affiliated Hospital of Guangxi University of Chinese Medicine from July 2014 to July 2016, were selected and divided into control group(n=80) and observation group(n=80). The control group was treated with conventional anti heart failure therapy, and the observation group was added low dose dopamine combined with milrinone on the basis of control group's therapy. The course of treatment was 7 d. The clinical efficacy,the left ventriculai ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), creatine kinase (CK), creatine kinase isoenzym (CK-MB), and the serum NT-proBNP levels before and after treatment were compared between the two groups. Results: The total effective rate (96.25%) of the observation group was higher than that (66.25%) of the control group (P<0.05). There were no significant differences in the levels of LVEF, LVEDD, CK, and CK-MB between the two groups before treatment(P>0. 05). After the treatment,the level of LVEF in the observation group was higher than that in the control group, while the levels of LVEDD, CK, CK-MB were lower than those in the control group (P<0.05). There was no significant difference in the levels of serum NT-proBNP between the two groups before treatment (P>0.05). The levels of serumNT-proBNP were significantly decreased in the two groups after treatment (P<0.05), and the level of serum NT-proBNP in the observation group was lower than that in the control group, the difference was statistically significant (P<0.05). Conclusion: A small dose of dopamine combined with milrinone is effective in the treatment of intractable heart failure. It is helpful to the recovery of cardiac function and can significantly reduce the level of serum NT-proBNP, which is worthy of clinical application. [ABSTRACT FROM AUTHOR]

Objective: To study the curative efficacy of wenxin granule combined with propafenone in the treatment of arrhythmia and its effects on the serum levels of hs-CRP，TNF-α，IL-6 and heart function. Methods: 96 patients of arrhythmia who were treated from July 2014 to October 2016 in our hospital were selected and randomly divided into the observation group (n=48) and the control group (n=48). The control group was treated with propafenone，while the observation group was treated with wenxin granuleon. Then the serum levels of hs-CRP，TNF-α and IL-6，heart function，clinical efficacy and incidence of adverse reactions were observed and compared between the two groups before and after the treatment. Results: After treatment，the total effective rate of observation group was significantly higher than that of the control group (P<0.05). The serum levels of hs-CRP，TNF-α and IL-6 of observation group were significantly lower than those of the control group (P<0.05); the left ventricular end diastolic dimension (LVEDD) and left ventricular end systolic diameter (LVESD) of observation group were significantly lower than those of the control group，and the left ventricular ejection fraction (LVEF) was significantly higher than that of control group(P< 0.05); the incidence of adverse reactions in the observation group was significantly lower than that of the control group (P< 0.05). Conclusion: Wenxin granule combined with propafenone was effective for arrhythmia，it could effectively improve the heart function and high safety，which might be related to the decrease of serum hs-CRP， TNF- and IL-6 levels. [ABSTRACT FROM AUTHOR]

Objective: To explore the effect of Losartan plus Shexiang Baoxin pill on patients of hypertension combined with heart failure. Methods: 152 cases treated in our hospital from January, 2014 to January, 2016 were randomly divided into the observation and control group with each group of 76 cases. Control group received conventional therapy of oxygen inhalation,β receptor blocker, on the basis o f which the observation group was given Losartan plus Shexiang Baoxin pill. The blood pressure, heart function, level of BNP, hs-CRP were compared in both groups. Results: After therapy, the blood pressure, level of LVESD, LVEDD , BNP and hs-CRP in both groups were significantly decreased compared with those ofbefore therapy (P<0.05), the level of LVEF (%) obviously increased compared with that of before therapy. and blood pressure, level of LVESD, LVEDD, BNP and hs-CRP in observation group were significantly lower than the control group (P<0.05); the level of LVEF (%) in observation group was significantly higher than control group (P<0.05); Conclusions: Losartan plus shexiangbaoxin pill has better clinical effect than conventional therapy in treating patients of hypertension combined with heart failure, which could effective improve cardiac function. [ABSTRACT FROM AUTHOR]

Objective: To study the value of echocardiography in the evaluation of fetal heart structure and function in pregnant women with gestational diabetes mellitus (GDM). Methods: 156 pregnant women with GDM in our hospital from January 2014 to December 2016 were selected as GDM group. In the same period, 50 healthy pregnant women with matched gestational age were randomly selected as control group. At the end of gestation, the fetuses of two groups were examined by the echocardiography, including fetal heart valve ring diameter, heart structure and heart function. Results: The MVA, TVA, AVA, PVA in fetals of the GDM group were higher than those of the control group, and the differences were statistically significant (P＜0.05). The IVSs, IVSd, LVWTd, LVWTs, RVWTd, RVWTs in fetals of the GDM group were higher than those of the control group, the differences were statistically significant (P＜0.05). The LVEF, LVFS, RVFS in fetals of the GDM group were higher than those of the control group, and the E/AMV, E/ATV were less than those of the control group, the differences were statistically significant (P＜0.05). The left ventricular Tei index (LV MPI)and right ventricular Tei index (RV MPI) of fetals of the GDM group were larger than those of the control group (P＜0.05). Conclusion: The fetal structure and function of pregnancy women with GDM have varying degrees of change, and echocardiography can effectively monitor the fetal heart structure and function, so that to provide early clinical intervention and improve prognosis. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of the timing of surgery on left ventricular remodeling and cardiac function after percutaneous coronary intervention in patients with acute myocardial infarction. Methods: 97 cases with acute myocardial infarction who had taken the percutaneous coronary interventional surgery in our hospital from October 2014 to October 2015 were selected as the research objects, and according to the different operation time, the patients were divided into the emergency surgery group (49 cases) and the selective surgery group (48 cases). Then the LVDEd, LVSEd, LAd, mMPG and mPAP of patients in the two groups before and after the operation were observed and compared. Results: There was no statistically significant difference about the hemodynamics and heart functions of patients in the two groups before the operation (P>0.05); After the operation, the LVDEd, LVSEd and LAd in the two groups decreased, and the emergency surgery group was lower than that of the selective surgery group, and the difference was statistically significant (P<0.05); After the operation, the mMPG and mPAP in the two groups decreased, and the emergency surgery group was lower than that of the selective surgery group, and the difference was statistically significant (P<0.05); The six-months' readmission rate of the emergency surgery group was 2.04%, which was lower than 6.25% in the selective surgery group, and the difference was statistically significant (P<0.05). Conclusion: The operation opportunity of percutaneous coronary intervention for patients with acute myocardial infarction is very important. Compared with the selective surgery, the emergency surgery can improve the cardiac function and left ventricular remodeling, reduce the rate of readmission, and it is worthy of clinical application. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of trimetazidine on heart function and expressions of MMP-9 and TIMP-1 of patients with chronic heart failure. Methods: 100 patients with chronic heart failure who were treated in our hospital from June 2012 to 2014 were selected and randomly divided into the observation group and the control group, with 50 cases in each group. The patients in the control group were treated with routine medicine, while the patients in the observation group were treated by the trimetazidine besides the conventional medicine. Then the heart rate(HR), left ventricular ejection fraction(LVEF) and the changes of MMP-9, TIMP-1 of the two groups were observed and compared. Results: After the treatment, HR decreased and LVEF increased in the two groups(P<0.05);LVEF of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05); After the treatment, TIMP-1 increased and MMP-9 decreased in the two groups(P<0.05); Compared with the control group, TIMP-1 increased and MMP-9 decreased in the observation group and the differences were statistically significant(P<0.05). The total efficacy of the observation group was significantly higher than that of the control group with statistically significant difference(P<0.05). Conclusion: Trimetazidine has good curative effect on the treatment of chronic heart failure by regulating the MMP-9 and TIMP-1 levels and improving the heart functions. [ABSTRACT FROM AUTHOR]

Objective: To observe and evaluate the efficacy of recombinant human brain natriuretic peptide (rhBNP) for the treatment of cardiorenal syndrome after cardiac surgery. Methods: Fifty patients with cardiorenal syndrome after cardiac surgery failed to the routine therapy with dopaminergics, diuretics, nitrates and milrinone, and then were given rhBNP intravenous pump for 48 h. The efficacy was observed. Results: After the additional treatment with rhBNP, the urine volume was obviously increased; serum creatinine(Scr) and blood urea nitrogen(BUN) was decreased; estimate glomerular filtration rate(eGFR) was increased; central venous pressure(CVP) reduced; and artery blood pressure(ABP) including both systolic and diastolic blood pressure was increased. After 48 hour, blood brain natriuretic peptide was lowered and the left ventricle ejection fraction(LVEF) was elevated 7 days later. Conclusions: Additional small dose rhBNP (<0.01 μg/kg/min) can help improve heart and renal function of patients with cardiorenal syndrome after cardiac surgery when routine therapy has no effect, which may improve patients' renal function first, and then heart function gets improved. [ABSTRACT FROM AUTHOR]

Objective: To study the effect of acclimatization time on heart function of soldiers rushing into plateau and the countermeasures. Methods: 241 male soldiers who needed to rush into plateau were selected. Their heart function under different acclimatization time at high altitude were observed, and targeted interventions explored. Results: When compared to before entering the plateau, the HP, LVEF, LVFS, CO and LVEDVI levels 3 days into plateau, the HP, LVEF, LVFS and LVEDVI levels 7 days into plateau, the HP, LVEF and LVEDVI levels 14 days into plateau, the HP level 30 days into plateau, all have statistical significance (P＜0.05). when compared to 3 days into plateau, the HP, LVEF, LVFS, CO and LVEDVI levels 30 days and 60 days into plateau all have statistical significance (P＜0.05). The HP level 30 days into plateau was lower than that in 7 days into plateau. The differences among HP, LVEF and LVEDVI levels between 60 days and 7 days into plateau were statistically significant (P＜0.05). The HP levels 30 and 60 days into plateau were both lower than that 14 days into plateau, and the differences statistically significant (P＜0.05). Conclusion: The heart function of soldiers will be greatly influenced when they are sudden at high altitude. With effective interventions and increase of acclimatization time, the influence will gradually disappear and will not affect the normal work and training of soldiers. [ABSTRACT FROM AUTHOR]