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To explore the Endoscopic sphincterotomy combined with different durations of endoscopic papillary balloon dilatation in patients with common bile duct stones. A total of 92 patients with common bile duct stones who underwent EST combined with EPBD in our hospital from January 2018 to December 2018 were selected as the study subjects. They were divided into group A according to the intraoperative balloon dilation time (46 patients, dilatation expansion time 20 s), group B (46 patients, dilatation expansion time 40 s), compared the two groups of patients with a net stone rate, mechanical lithotripsy rate, operation time and X-ray exposure time, compared the two groups of patients with liver function indicators before and after surgery The blood amylase at 12 hours after operation was compared with the incidence of complications such as pancreatitis, gastrointestinal bleeding, biliary infection, and perforation in the two groups. (1) The comparison showed that there was no statistically significant difference between the two groups of patients in the rate of clean stones, mechanical lithotripsy, operating time, X-ray exposure time, and 12 h blood amylase (P>0.05). (2) The differences in TBIL, ALT, and ALP between the two groups of patients before surgery were not statistically significant (P>0.05). The above indicators in the two groups of patients showed a significant decrease compared with that before treatment, but there was no difference between the groups(P>0.05). (3) The incidence of various postoperative complications in group A was 4.35 % (2/46), and the incidence of various postoperative complications in group B was 17.39 %(8/46). The difference between the two groups was statistically significant (P<0.05). EST combined with EPBD has a good therapeutic effect on common bile duct stones. Different balloon inflation times during the operation will not affect the success rate and operation time, but long-term expansion will increase the risk of postoperative bleeding. In the case of surgery, try to control the balloon dilation time during the operation. [ABSTRACT FROM AUTHOR]