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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To study the first aid effect of ulinastatin in treatment of acute paraquat poisoning and its influence on the serum interleukin-18（IL-18）, matrix metalloproteinase-9（MMP-9） and high mobility group protein B1（HMGB1） levels, biochemical index and blood gas index. Methods: 80 patients of chronic renal failure who received therapy from January 2016 to January 2019 in our hospital were selected, according to random number table, they were divided into the observation group and the control group, each group had 40 cases. The control group was given routine treatment, while the observation group was treated with ulinastatin on the basis of the control group. The serum levels of IL-18, MMP-9, HMGB1, biochemical indexes, blood gas analysis, 28-day complications and mortality were compared between the two groups. Results: After treatment 7 days, the serum IL-18, MMP-9, HMGB1, alanine aminotransferase（ALT）, creatinine（Cr）, creatine kinase isoenzymes（CK-MB）, partial pressure of carbon dioxide（PaCO2） in the observation group were significantly lower than those in the control group, and partial pressure of oxygen（PaO2） in blood was significantly higher than those in the control group, the differences were statistically significant（P<0.05）; the 28-day pulmonary failure, renal failure, toxic myocarditis, multiple organ dysfunction syndrome（MODS） and mortality rate in the observation group were significantly lower than those in the control group, the differences were statistically significant（P<0.05）. Conclusion: Ulinastatin has a remarkable first aid effect on acute paraquat poisoning, and can alleviate the tissues and organs inflammation damage caused by serum IL-18, MMP-9 and HMGB1,improve biochemical index and blood gas indicators, and reduce the incidence of organ injury and mortality, it’s worth popularizing. [ABSTRACT FROM AUTHOR]

With the rapid development of science and technology, the emergence of various kinds of new media has made some medical events with higher attention. In recent years, medical disputes are becoming more and more serious,in the era of the all media era, the frequent occurrence of hospital public opinion crisis has great adverse effects on hospital reputation and doctor-patient relationship. How to correctly guide the network public opinion, reduce the adverse impact of the hospital public opinion crisis has become an urgent problem to be solved. This study discusses the hospital crisis management of public opinion in all media era, from the existing hospital management, hospital public opinion public opinion management problems and related measures of the three aspects, the aimis to provide reference for hospital managers to control hospital public opinion, resolve emergency hospital incidents and improve doctor-patient relationship under the full media background. [ABSTRACT FROM AUTHOR]

Neural Tube Defects are serials congenital malformations caused by the failure closure of neural tube in the early stage of embryogenesis which manifest dyplasia of brain and spinal. There has no definite conclusion on the pathogenesis and etiology of NTDs. A lot of risk factors involve in the occurrence of NTDs which include genetics, environments, and the interaction between them. The study on genetics major in seeking for the pathogenetic genes and study the functions in the development of NTDs. However, the study of gene knockout experiments can not explain the occurrence of NTDs due to the complex etiological factors. In rencent years, epigenetics play an important role in regulating relevant genes involved in NTDs. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the indication and treatment of pregnancy complicated with uterine myoma during cesarean section. Methods: Selected 80 cases of patients with uterine myoma who were treated in our hospital from January 2011 to December 2015, divided into two groups according to the treatment, 40 cases in observation group, 40 cases in control group. The observation group was treated with uterine myoma and cesarean section, the control group was treated with simple cesarean section, and 40 cases of normal cesarean section were selected as the routine group. The blood loss, the operation time, intraoperative, before and after the operation of the difference of hemoglobin, postoperative anal exhaust time and hospitalization time: different myoma size, type and number of intraoperative blood loss in the observation group wwere recorded; the neonatal outcome, and maternal postpartum recovery of the three groups were compared. Results: The general condition of the leiomyoma size, type and number in observation group and control group showed no significant difference (P>0.05): the operation time of the observation group was significantly longer than that of the control group and routine group (P<0.05), the amount of bleeding in operation among the three groups, the difference of hemoglobin before and after the operation, the postoperative anal exhaust time and hospitalization time had no significant difference (P>0.05): the bleeding volume of the patients with uterine myoma size < 5 cm was significantly less than that of above 5 cm(P<0.05), and different tumor types and number of intraoperative bleeding had no significant difference(P>0.05): the incidence of apgar scored 7 points, birth weight<2500 g. fetal development retardation and premature of the control group and observation group were significantly higher than those in the conventional group(P<0.05), there was no significant difference between the control group and the observation group (P> 0.05). Conclusions: If the fibroids diameter of pregnancy complicated with uterine myoma is< 5 cm. it can be considered to perform myomectomy, when the diameter > 5 cm. the amount of bleeding during operation ismore and the risk isgreater. cesarean section should not be done at the same time. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Chimeric antigen receptor modified-T lymphocytes (CAR-T) based adoptive antitumor immunotherapy has became an emerging therapeutic modality for malignant tumor in recent years. CAR-T cells give the targeted killing activity of T lymphocytes,which they can resist the tumor immunosuppression and break the host immune tolerance. Although there still exist many problems for CAR-T on the clinical application such as off-target effects, cytokine storm, insertion mutagenesis, graft versus host disease-like damage and many other problems, but we believe that with the in-depth study of the CAR-T cells and application will greatly improve the therapeutic effects of tumor. We summarized the past history, present status and future prospect of tumor immunotherapy adopting CAR-T in this review. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Methylglyoxal (MG), a toxic by-product of glycolysis, plays an important role in the process of Alzheimer's disease (AD) with its high reactivity. Accumulated MG in AD patients' brains promotes β-amyloid peptide (Aβ) production and oligomerization. Accumulated methylglyoxal induces tau hyperphosphorylation via Promoting advanced glycosylation end products (AGEs) Formation. Previous studies found that MG and AGEs are both involved in the production of reactive oxygen species (ROS) and the development of inflammation in AD patients' brains. In this article, we brief summarize and review the role of MG in pathological process of AD. [ABSTRACT FROM AUTHOR]