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Objective: To explore the value of uterine arterial blood flow parameters combined with serum placental growth factor (PLGF) and pregnancy associated plasma protein-A (PAPP-A) in predicting the pregnancy outcome of pregnant women with unexplained recurrent spontaneous abortion (URSA) during early pregnancy. Methods : 103 pregnant women with URSA history who were admitted to our hospital from October 2021 to October 2022 were selected. Their pregnancy outcome at 28 weeks were tracked, and they were divided into normal pregnancy group (n=26) and abortion group (n=77) according to different pregnancy outcome. The uterine artery blood flow parameters [resistance index (RI), pulsation index (PI), peak systolic flow velocity/end-diastolic flow velocity (S/D)] and serum PLGF and PAPP-A levels were compared in the two groups. Multivariate Logistic regression model was used to analyze the influencing factors of pregnancy outcome of pregnant women with URSA during early pregnancy. The predictive value of uterine artery blood flow parameters combined with serum PLGF and PAPP-A for pregnancy outcome of pregnant women with URSA during early pregnancy was analyzed by receiver operating characteristic (ROC) curve. Results: The PI, RI and S/D in the abortion group were significantly higher than those in the normal pregnancy group (P＜0.05), while serum PLGF and PAPP-A levels were significantly lower than those in the normal pregnancy group (P＜0.05). Logistic regression model showed that the elevated PI, RI and S/D were the risk factor for pregnancy outcome of pregnant women with URSA during early pregnancy (P＜0.05), while the elevated serum PLGF and PAPP-A levels were the protective factor (P＜0.05). ROC analysis results showed that the combination of PI, RI, S/D, PLGF, and PAPP-A had the highest efficacy in predicting the pregnancy outcome of pregnant women with URSA during early pregnancy, and the area under the curve (AUC) of combined diagnosis was 0.913, which was significantly better than the diagnosis of each index alone. Conclusion: Uterine arterial blood flow parameters combined with serum PLGF and PAPP-A have high value in predicting pregnancy outcome of pregnant women with URSA during early pregnancy. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the clinical efficacy of calcitriol combined with peritoneal dialysis in the treatment of chronic renal failure and its effects on the serum ProGRP, Cysc and Chemerin levels. Methods: 98 patients with chronic renal failure who were treated from February 2017 to January 2018 in our hospital were selected as the research objects. According to the random number table, those patients were divided into the observation group (n=47) and the control group (n=51). The control group was treated with peritoneal dialysis, while the observation group treated with Calcitriol combined with peritoneal dialysis. The changes of blood urea nitrogen (BUN), serum creatinine (Cr), 24-hour urinary protein (24-hour UP), albumin (Alb), hemoglobin (Hb), red blood cell (RBC), gastrin-releasing peptide precursor (ProGRP), serum CysC and Chemerin levels before and after treatment, 6-month and 1-year survival rates as well as the incidence of adverse reactions were compared between two groups. Results: After treatment, the BUN, SCr and 24hUP levels in the observation group were significantly lower than those in the control group [(13.95 ± 3.06)mmol/L vs. (21.10 ± 3.85)mmol/L, (260.12± 40.32) μmol/L vs. (354.93± 51.06) μmol/L, (1.75± 0.45)g/24 h vs. (2.67± 0.80)g/24 h](P<0.05). The Alb level was significantly lower than that of the control group [(27.85± 3.58)g/L vs. (33.06± 4.27)g/L](P＜0.05). The Hb and RBC were significantly higher than those in the control group[(91.72± 13.46)g/L vs. (82.36± 10.15)g/L, (379.47± 92.08)× 1012/L vs(315.70± 73.24)× 1012/L](P<0.05). ProGRP and Chemerin levels were significantly lower than those in the control group [(49.23± 4.72) pg/mL vs. (63.87± 7.30) pg/mL, (37.02± 6.15)滋g/L vs. (30.63± 4.81)μg/L](P<0.05). The Cysc level was significantly higher than that of control group [(80.75± 16.08) ml/min vs. (98.81± 18.07)ml/min](P＜0.05). The 6-month and 1-year survival rates were significantly higher than those in the control group[96.08%(49/51) vs.91.49%(43/47), 90.20%(46/51) vs.74.47%(35/47)](P<0.05). The total incidence of adverse reactions was significantly lower than that in the control group [17.65%(9/51) vs.44.68%(21/47)](P<0.05). Conclusion: Calcitriol combined with peritoneal dialysis has a better clinical effect on chronic renal failure than single use. It can effectively alleviate the clinical symptoms, correct the electrolyte disturbance, improve the renal function and prognosis. It may be related to lower the serum levels of ProGRP, Cysc, Chemerin and increase the serum levels of Cysc. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To observe the effects of Jiawei Zhenwu Tang on chronic heart failure rats myocardial tissue structure and the level of inflammatory factors, and explore its mechanism. 48 male SD rats were randomly divided into control group, model group, digoxin group, Jiawei Zhenwu Tang group. Chronic heart failure rat model was established by intraperitoneal injection of doxorubicin hydrochloride. The rats in each group were treated after administration, the myocardial cell structure and pathological score were observed under light microscope; the levels of interleukin -1, interleukin -6 and serum brain natriuretic peptide were measured by enzyme-linked immunosorbent assay. In the model group, the myocardial fibers were broken and accompanied by inflammatory infiltration. The pathological score of the model group was significantly higher than that of the control group, with statistical difference (P < 0.05); The pathological scores of the digaoxin group and the Jiawei Zhenwu Tang group were significantly lower than that of the model group, with statistical difference (P < 0.05); There was no significant difference in the pathological scores between the Jiawei Zhenwu Tang group and the digaoxin group (P > 0.05). Compared with the model group, the levels of IL-6, IL-1 and BNP in the Jiawei Zhenwu Tang group and the digaoxin group were significantly decreased, the effect of the Jiawei Zhenwu Tang group was more significant, the difference was statistically significant (P < 0.05). The Jiawei Zhenwutang may have some effects, such as increase increasing myocardial contractility, inhibiting the release of inflammatory factors,slowing ventricular remodeling, and protecting cardiomyocytes. [ABSTRACT FROM AUTHOR]

Obejective: To evaluate the clinical efficacy of lisinopril and Benner Pury in the treatment of hypertensive stroke and on serumasymmetric dimethylarginine (ADMAtwo) levels, in order to provide guidance for the treatment of hypertension and stroke. Methods: 246 cases of hypertensive stroke from January 2014-March 2016 who received treatment in our hospital diagnosed, according to the random number table method were randomly divided into study group compare group and conventional group, 82 cases in each group. The conventional group received basic treatment, study group with basic treatment combined with lisinopril treatment, the control group was treated with combined therapy of Benner Pury treatment. The blood pressure parameters, serum ADMA and Hcy levels, treatment effects and adverse reactions were compared between the 3 groups before and after treatment. Results: There were no significant differences in the blood pressure, serum ADMA and Hcy levels and mRS scores of the three groups of patients before treatment (SBP, DBP and PP); the index levels after treatment were significantly lower than before treatment (P<0.05), and the index of patients in the study group was significantly lower than the control group and normal group (P<0.05). The effective rate of the treatment group was significantly higher than that of the control group and the conventional group, the effective rate of the treatment group was significantly higher than that of the conventional group, the difference was statistically significant (P<0.05). There was no significant difference in adverse reaction rate between the three groups (P>0.05). Conclusions: Lisinopril and Benner Pury can effectively lower blood pressure in hypertensive patients with cerebral stroke, improve endothelial function, with significant effect; but the effect of lisinopril to is better than Benner Pury, more worthy of promotion. [ABSTRACT FROM AUTHOR]

Objective: To compare the anesthesia effects for patients with laparoscope hysterectomy between the total intravenous anesthesia using Propofol target-controlled infusion and Sevoflurane intravenous-inhalation combined anesthesia guided by bispectral index. Methods: In this study, 46 patients, at ASA I - II grade, would get selected laparoscope hysterectomy were recruited. They were randomly divided into two groups: total intravenous anesthesia using Propofol target-controlled infusion group (TCI group) and Sevoflurane intravenous-inhalation combined anesthesia (SD group). BIS was monitored for every patient. Hemodynamic parameters including blood pressure(BP) and heart rate(HR) were observed before anesthesia induction, at 30 min after the beginning of operation and 1 h after the end. The incidence of intraoperative awareness in the patients was observed. And the inducing time, recovery time of spontaneous breathing, eye opening time and extubation time were recorded. The 24h postoperative nausea and vomiting (PONY) of the patients were observed after operation. Results: No statistical differences were observed in blood pressure and heart rate at each time point between TCI group and SD group (P>0.05). There was no case of intraoperative awareness in the two groups. The recovery time of spontaneous breathing, eye opening time and extubation time in TCI group all were earlier than in SD group, and the differences were statistically significant (P<0.05). In addition, the incidence of 24 h PONV was significantly lower in TCI group than in SD group (P< 0.05). Conclusion: The total intravenous anesthesia using Propofol target-controlled infusion and Sevoflurane intravenous-inhalation combined anesthesia guided by bispectral index both were perfectly safe and could prevent against intraoperative awareness for the patients with laparoscope hysterectomy. But patients with total intravenous anesthesia using target-controlled infusion got faster anesthesia recovery and lower incidence of 24 h postoperative nausea and vomiting. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)