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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the association of ELrs3829632 polymorphismwith cervical cancer in Jiangsu province. Methods: Using a case-control study, 328 CC patients and 356 age matched controls were enrolled in Nantong Maternal and Child Health Care Hospital and Nantong Cancer Hospital. Genomic DNA was extracted from blood samples and DNA sequence was used to determine the genotype of EL rs3829632 polymorphism. Real-time PCR and Western blot were used to determine the mRNA and protein expressions of EL in diseased tissues fromcervical cancer patients. Results: Compare to TT genotype, individuals with rs3829632 C allele showed an increased risk for cervical cancer. And in cervical cancer patients, rs3829632 TT genotype carriers exhibited the highest EL expression both in mRNA and protein levels than other genotype carriers. Concluvion: The rs3829632 C allele is associated with increased risk for cervical cancer, which may be caused by abnormal expression and dysfunction of EL and subsequent aberrant lipid metabolismin cervical cells. [ABSTRACT FROM AUTHOR]