Objective: To investigate the clinical value of compound vacuum suction external fixation plate for the treatment of open fracture of limbs. Methods: From January 2014 to January 2017. 68 cases of patients with open fracture of tibia and fibula treated in our hospital were selected as the research object and divided into the observation group and the control group with 34 cases in each group according to the random lottery envelopes. The control group was treated with vacuum sealing drainage(VSD) conventional external fixation plate treatment the observation group was given compound vacuum suction external fixation plate treatment, the the incidence of severe complications during perioperative period, operation time, fracture healing time, clinical efficacy and wound healing were recorded and compared between two groups. Results: All the patients in both groups completed the surgery and there was no serious complications during the perioperative period, the operation time, fracture healing time in the observation group were 38.24± 8.16 min and 8.83± 1.01 weeks, which were significantly less than those of the control group (49.50± 9.87 min and 12.23± 0.91 weeks)(P<0.05). The excellent and good rate of observation group and control group at 3 months postoperation were 97.1% and 82.4%. respectively, which was significantly higher in the observation group than that of the control group (P<0.05). The quality of wound healing at 3 months postoperation in the observation group showed 28 cases of Class A healing and 6 cases of Class B healing, which were 21 cases of Class A healing. 8 cases of Class B healing and 5 cases of Class C healing in the control group, the wound healing of observation group was better than mat of the control group (P<0.05). Conclusion: Compound vacuum suction external fixation plate could obviously shorten the operation time, improve the fracture healing and the quality of wound healing for the treatment of open fracture of limbs. [ABSTRACT FROM AUTHOR]