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Objective: To study the effects of Guizhi Fuling bolus combine with mifepristone on hemorheology, hemoglobin (Hb) and human epididymis protein 4 (HE4) in patients with hysteromyoma. Methods: 172 patients with hysteromyoma treated in 3201 Hospital Affiliated to Medical College of Xi'an Jiaotong University from March 2016 to May 2017 were selected, the patients were randomly divided into the observation group (n=86) and the control group (n=86). The control group was treated with mifepristone, the observation group was treated with Guizhi Fuling bolus on the basis of the control group, the efficacy was compared between the two groups after 3 months treatment, the Hb, HE4, myoma volume, blood rheology indexes were compared between the two groups before treatment and after 3 months treatment, the adverse reaction was compared between the two groups. Results: The total effective rate of the observation group was 97.67%, which was higher than 89.53%of the control group (P<0.05). After treatment, the levels of Hb in both groups were significantly higher than before treatment, which in the observation group was higher than the control group (P<0.05). The level of HE4 in both groups was lower than that before treatment, the observation group was lower than that in the control group (P<0. 05), and the fibroid volume was smaller than that before treatment, and the observation group was smaller than that in the control group (P<0.05). After treatment, the total blood viscosity (HBV), total blood viscosity (LBV), plasma viscosity (PV) and platelet aggregation rate (PAR) of the two groups were lower than before treatment, and the observation group was lower than the control group (P<0.05). The total incidence of adverse reactions in the observation group and control group were 13.95% and 10.47%, which was no significant difference (P>0.05). Conclusion: Guizhi poring bolus combined with mifepristone is effective in treating uterine fibroids, which can improve the level of hemorheology, Hb, HE4 and other indicators, with good safety and worth popularizing. [ABSTRACT FROM AUTHOR]