The relation between politics, ontology, and space remains one of the most contested concerns in human geography, often leading to a dismissal of ontology in favor of the politicization of space. In contrast, this article mobilizes post-foundationalism to propose a political ontology of space. After reviewing geographers’ engagements with politics, post-politics and the political, the article demonstrates how a post-foundational geography radically uproots geographic understandings of political and socio-spatial realities. Grounded upon parameters of negativity, contingency, and antagonism, the article equips geographers to grapple with the crumbling foundations of an uncertain present, and unknown futures.