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Introduction: Melkersson-Rosenthal syndrome (MRS) is a rare neurologic disease of unknown etiology. It is characterized by a triad of symptoms: relapsing peripheral facial paralysis; orofacial edema and fissured tongue. The pathological findings are varied but often characterized by the presence of noncaseating granuloma. There are few cases of MRS coexistent with Hashimoto disease in the literature. Purpose: To present a case of MRS coexistent with Hashimoto disease Case presentation: We report a case of a 32-year-old woman with coexisting MRS and autoimmune thyroiditis, Hashimoto disease. Fissured tongue and recurrent cheilitis of the upper lip were observed. In her medical history, she had facial nerve palsy. Histopathological examination of the upper lips mucose membrane revealed the presence of granulomas confirming the diagnosis. Conclusions: Cooperation between clinicians and histopathologists is vital in diagnosing MRS. The presence of the anti-TPO antibodies in the case reported here could suggest a correlation between immunological alteration characteristics of autoimmune thyroiditis and MRS. [ABSTRACT FROM AUTHOR]

Introduction: Malignant mixed tumor (MMT) is an exceedingly rare cutaneous adnexal carcinoma with a significant risk for aggressive behavior and a propensity for metastasis. This tumor occurs in a wide age range and is twice as common in woman than in men. MMT shows a predilection for the trunk and the extremist's foremost hands and feet. MMT may be confused clinically with many benign and malignant lesions. Therefore the histopathological and immunohistochemical examination is required for the correct diagnosis and treatment. Purpose: To present a case of MMT localized in the left toe with a special attention focused on its histopathology and differential diagnosis. Case presentation: A 56-year-old female was admitted with a nodular lesion on the left toe. A painless mass had been presented for one year with a significant increase in size within the past three month. The patient underwent wide surgical excision. Histopathologically for the lesion was diagnosed it as a malignant mixed tumor. Immunohistochemical examination revealed positive reaction for cytokeratin AE1/AE3/PCK26, vimentin and S-100. Histochemical reaction for PAS in the chondromyxoid tumor stroma was negative. Conclusion: Correct histopathological diagnosis and complete excision with wide disease-free margins before metastasis result in MMT free survival. [ABSTRACT FROM AUTHOR]