Author: "F-K. Lin" / Journal: progress in clinical and biological research - Searchworks@Jio Institute Digital Library Search Results

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Start Over Author "F-K. Lin" Journal progress in clinical and biological research

Author: P P, Dukes, J C, Egrie, T W, Strickland, J K, Browne, and F K, Lin
Subjects: Colony-Forming Units Assay, Macaca fascicularis, Mice, Bone Marrow, Animals, Humans, Bone Marrow Cells, In Vitro Techniques, Erythropoietin, Megakaryocytes, Recombinant Proteins
Published: 1986

Author: J C, Egrie, J, Browne, P, Lai, and F K, Lin
Subjects: Ovary, DNA, Recombinant, Anemia, DNA, DNA Restriction Enzymes, Haplorhini, Cell Line, Molecular Weight, Cricetulus, Gene Expression Regulation, Cricetinae, Animals, Humans, Female, Rabbits, Erythropoietin
Abstract: We have isolated the human EPO gene from a human genomic lambda library and a monkey EPO cDNA from an anemic monkey kidney cDNA library. These sequences have been expressed in both COS1 and Chinese hamster ovary cells. The expressed EPO has been shown to be fully biologically active both in vitro and in vivo and immunologically identical to the native hormone. In addition, administration of recombinant EPO to animals causes a dramatic increase in their hematocrit.
Published: 1985

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