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Start Over Author "Isacson, O" Journal progress in brain research
21 results on '"Isacson, O"'

10. Characterization and criteria of embryonic stem and induced pluripotent stem cells for a dopamine replacement therapy.

Author

Cooper O, Parmar M, and Isacson O

Subjects
Animals, Humans, Mesencephalon cytology, Mesencephalon transplantation, Parkinson Disease surgery, Stem Cell Transplantation, Cell Differentiation physiology, Dopaminergic Neurons physiology, Embryonic Stem Cells physiology, Embryonic Stem Cells transplantation, Induced Pluripotent Stem Cells physiology, Induced Pluripotent Stem Cells transplantation
Abstract

Human pluripotent stem cells provide new choices for sources of A9-type dopaminergic (DA) neurons in clinical trials of neural transplantation for patients with Parkinson's disease (PD). For example, "self" and HLA-matched A9 DA neurons may improve the patient-to-patient variability observed in previous clinical trials using fetal DA neurons and obviate the need for long-term immunosuppression in the patient. Normal chromosomal structure and minimal somatic mutations in pluripotent stem cells are necessary criteria for assuring the safe and reproducible transplantation of differentiated DA neurons into patients with PD in clinical trials. However, with these new choices of cell source, the application of pluripotency assays as criteria to ensure pluripotent stem cell quality becomes less relevant. New more relevant standards of quality control, assurance, and function are required. We suggest that quality assurance measures for pluripotent stem cells need to focus upon readouts for authentic midbrain DA neurons, their integration and growth using in vivo assays, and their long-term functional stability., (Copyright © 2012 Elsevier B.V. All rights reserved.)

Published
2012
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11. Regulation of dopamine cell type and transmitter function in fetal and stem cell transplantation for Parkinson's disease.

Author

Björklund LM and Isacson O

Subjects
Animals, Brain Tissue Transplantation methods, Dopamine metabolism, Graft Survival physiology, Humans, Neurons cytology, Neurons metabolism, Parkinson Disease pathology, Parkinson Disease physiopathology, Recovery of Function physiology, Stem Cell Transplantation methods, Substantia Nigra cytology, Substantia Nigra embryology, Substantia Nigra metabolism, Synaptic Transmission physiology, Brain Tissue Transplantation trends, Parkinson Disease surgery, Stem Cell Transplantation trends
Published
2002
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12. Cellular delivery of trophic factors for the treatment of Huntington's disease: is neuroprotection possible?

Author

Kordower JH, Isacson O, Leventhal L, and Emerich DF

Subjects
Animals, Cell- and Tissue-Based Therapy, Cells, Cultured transplantation, Ciliary Neurotrophic Factor pharmacology, Ciliary Neurotrophic Factor therapeutic use, Disease Models, Animal, Graft Survival physiology, Humans, Huntington Disease pathology, Huntington Disease physiopathology, Neostriatum pathology, Neostriatum physiopathology, Neostriatum surgery, Nerve Growth Factor pharmacology, Nerve Growth Factor therapeutic use, Brain Tissue Transplantation, Drug Delivery Systems methods, Huntington Disease surgery, Nerve Growth Factors therapeutic use, Neuroprotective Agents therapeutic use
Published
2000

14. Apomorphine-induced dyskinesias after excitotoxic caudate-putamen lesions and the effects of neural transplantation in non-human primates.

Author

Isacson O, Hantraye P, Maziere M, Sofroniew MV, and Riche D

Subjects
Animals, Caudate Nucleus physiopathology, Corpus Striatum pathology, Dyskinesia, Drug-Induced etiology, Dyskinesia, Drug-Induced physiopathology, Huntington Disease physiopathology, Ibotenic Acid, Male, Putamen physiopathology, Rats, Species Specificity, Transplantation, Heterologous, Apomorphine toxicity, Brain Tissue Transplantation, Caudate Nucleus drug effects, Corpus Striatum transplantation, Disease Models, Animal, Dyskinesia, Drug-Induced surgery, Fetal Tissue Transplantation, Huntington Disease surgery, Papio physiology, Putamen drug effects
Published
1990
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17. Striatal grafts in the ibotenic acid-lesioned neostriatum: functional studies.

Author

Dunnett SB, Isacson O, Sirinathsinghji DJ, Clarke DJ, and Björklund A

Subjects
Animals, Brain Diseases chemically induced, Corpus Striatum transplantation, Dopamine physiology, Globus Pallidus metabolism, Ibotenic Acid, Psychomotor Performance, Stereotyped Behavior physiology, gamma-Aminobutyric Acid metabolism, Corpus Striatum physiopathology
Published
1988
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19. Fetal cortical cell suspension grafts to the excitotoxically lesioned neocortex: anatomical and neurochemical studies of trophic interactions.

Author

Isacson O, Wictorin K, Fischer W, Sofroniew MV, and Björklund A

Subjects
Animals, Brain Diseases chemically induced, Brain Diseases pathology, Cell Communication, Cerebral Cortex embryology, Cytological Techniques, Female, Neurons physiology, Neurotoxins, Rats, Rats, Inbred Strains, Cerebral Cortex cytology, Neurons transplantation
Published
1988
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20. Experimental studies on the induction and prevention of retrograde degeneration of basal forebrain cholinergic neurons.

Author

Sofroniew MV, Pearson RC, Isacson O, and Björklund A

Subjects
Alzheimer Disease pathology, Animals, Cerebral Cortex pathology, Cholinergic Fibers drug effects, Colchicine pharmacology, Gangliosides pharmacology, Hippocampus pathology, Humans, Neurotoxins pharmacology, Substantia Innominata pathology, Brain pathology, Cholinergic Fibers pathology, Nerve Degeneration drug effects, Retrograde Degeneration drug effects
Published
1986
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