Search

Your search keyword '"Trent, Jeffrey M"' showing total 15 results
Start Over Author "Trent, Jeffrey M" Journal proceedings of the national academy of sciences of the united states of america
15 results on '"Trent, Jeffrey M"'

7. Advancing a clinically relevant perspective of the clonal nature of cancer

Author

Ruiz, Christian, Lenkiewicz, Elizabeth, Evers, Lisa, Holley, Tara, Robeson, Alex, Kiefer, Jeffrey, Demeure, Michael J., Hollingsworth, Michael A., Shen, Michael, Prunkard, Donna, Rabinovitch, Peter S., Zellweger, Tobias, Mousses, Spyro, Trent, Jeffrey M., Carpten, John D., Bubendorf, Lukas, Von Hoff, Daniel, and Barrett, Michael T.

Published
2011

14. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.

Author

Jianfeng Xu, Zheng, Siqun Lilly, Isaacs, Sarah D., Wiley, Kathleen E., Wiklund, Fredrik, Jielin Sun, Kader, A. Karim, Ge Li, PurceIl, Lina D., Seong-Tae Kim, Hsu, Fang-Chi, Stattin, Pär, Hugosson, Jonas, Adolfsson, Jan, Walsh, Patrick C., Trent, Jeffrey M., Duggan, David, Carpten, John, Grönberg, Henrik, and Isaacs, William B.

Subjects
PROSTATE cancer patients, GENOTYPE-environment interaction, CANCER treatment, GENETIC polymorphisms, CANCER in men, DIAGNOSIS
Abstract

Autopsy studies suggest that most aging men will develop lesions that, if detected clinically, would be diagnosed as prostate cancer (PCa). Most of these cancers are indolent and remain localized; however, a subset of PCa is aggressive and accounts for more than 27,000 deaths in the United States annually. Identification of factors specifically associated with risk for more aggressive PCa is urgently needed to reduce overdiagnosis and overtreatment of this common disease. To search for such factors, we compared the frequencies of SNPs among PCa patients who were defined as having either more aggressive or less aggressive disease in four populations examined in the ,Genetic Markers of Susceptibility (CGEMS) study performed by the National Cancer Institute. SNP5 showing possible associations with disease severity were further evaluated in an additional three independent study populations from the United States and Sweden. In total, we studied 4,829 and 12,205 patients with more and less aggressive disease, respectively. We found that the frequency of the Yr genotype of SNP rs4054823 at 17p12 was consistently higher among patients with more aggressive compared with less aggressive disease in each of the seven populations studied, with an overall P value of 2.1 × 10-8 under a recessive model, exceeding the conservative genome-wide significance level. The difference in frequency was largest between patients with high-grade, non-organ-confined disease compared with those with low-grade, organ-confined disease. This study demonstrates that inherited variants predisposing to aggressive but not indolent PCa exist in the genome, and suggests that the clinical potential of such variants as potential early markers for risk of aggressive PCa should be evaluated. [ABSTRACT FROM AUTHOR]

Published
2010

15. AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the...

Author

Ray, Michael E., Wistow, Graeme, Su, Yan A., Meltzer, Paul S., and Trent, Jeffrey M.

Subjects
GENES, MELANOMA treatment, CARCINOGENESIS
Abstract

Describes the AIM1, a novel gene whose expression is associated with the experimental reversal of tumorigenicity of human malignant melanoma. Similarity to the betagamma-crystallin superfamily; Motifs and structure; Homologous introns delineating equivalent protein structural units.

Published
1997
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results