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Your search keyword '"Taniguchi, Masaru"' showing total 25 results
Start Over Author "Taniguchi, Masaru" Journal proceedings of the national academy of sciences of the united states of america
25 results on '"Taniguchi, Masaru"'

6. Involvement of Decidual Vα 14 NKT Cells in Abortion

Author

Ito, Katsura, Karasawa, Mika, Kawano, Tetsu, Akasaka, Takeshi, Koseki, Haruhiko, Akutsu, Yasunori, Kondo, Eisuke, Sekiya, Souei, Sekikawa, Kenji, Harada, Michishige, Yamashita, Masakatsu, Nakayama, Toshinori, and Taniguchi, Masaru

Published
2000

13. KLRG⁺ invariant natural killer T cells are long-lived effectors

Author

Shimizu, Kanako, Sato, Yusuke, Shinga, Jun, Watanabe, Takashi, Endo, Takaho, Asakura, Miki, Yamasaki, Satoru, Kawahara, Kazuyoshi, Kinjo, Yuki, Kitamura, Hiroshi, Watarai, Hiroshi, Ishii, Yasuyuki, Tsuji, Moriya, Taniguchi, Masaru, Ohara, Osamu, and Fujii, Shin-ichiro

Published
2014

20. Transcriptional regulator Bhlhe40 works as a cofactor of T-bet in the regulation of IFN-γ production in iNKT cells

Author

Kanda, Masatoshi, Yamanaka, Hiroyuki, Kojo, Satoshi, Usui, Yuu, Honda, Hiroaki, Sotomaru, Yusuke, Harada, Michishige, Taniguchi, Masaru, Suzuki, Nao, Atsumi, Tatsuya, Wada, Haruka, Baghdadi, Muhammad, and Seino, Ken-ichiro

Subjects
interferon-γ, basic helix-loop-helix transcription factors, chromatin, interferon-gamma, T-box transcription factor Tbx21, Bhlhe40, natural killer T cells
Abstract

Invariant natural killer T (iNKT) cells are a subset of innate-like T cells that act as important mediators of immune responses. In particular, iNKT cells have the ability to immediately produce large amounts of IFN-γ upon activation and thus initiate immune responses in various pathological conditions. However, molecular mechanisms that control IFN-γ production in iNKT cells are not fully understood. Here, we report that basic helix-loop-helix transcription factor family, member e40 (Bhlhe40), is an important regulator for IFN-γ production in iNKT cells. Bhlhe40 is highly expressed in stage 3 thymic iNKT cells and iNKT1 subsets, and the level of Bhlhe40 mRNA expression is correlated with Ifng mRNA expression in the resting state. Although Bhlhe40-deficient mice show normal iNKT cell development, Bhlhe40-deficient iNKT cells show significant impairment of IFN-γ production and antitumor effects. Bhlhe40 alone shows no significant effects on Ifng promoter activities but contributes to enhance T-box transcription factor Tbx21 (T-bet)-mediated Ifng promoter activation. Chromatin immunoprecipitation analysis revealed that Bhlhe40 accumulates in the T-box region of the Ifng locus and contributes to histone H3-lysine 9 acetylation of the Ifng locus, which is impaired without T-bet conditions. These results indicate that Bhlhe40 works as a cofactor of T-bet for enhancing IFN-γ production in iNKT cells.

Published
2016

21. KLRG+ invariant natural killer T cells are long-lived effectors.

Author

Shimizu, Kanako, Yusuke Sato, Shinga, Jun, Takashi Watanabe, Endo, Takaho, Miki Asakura, Satoru Yamasaki, Kazuyoshi Kawahara, Yuki Kinjo, Hiroshi Kitamura, Hiroshi Watarai, lshii, Yasuyuki, Tsuji, Moriya, Taniguchi, Masaru, Ohara, Osamu, and Fujii, Shin-ichiro

Subjects
T cells, LYMPHOCYTES, VACCINATION, IMMUNE response, ANTIGENS
Abstract

Immunological memory has been regarded as a unique feature of the adaptive immune response mediated in an antigen-specific manner by T and B lymphocytes. However, natural killer (NK) cells and yδT cells, which traditionally are classified as innate immune cells, have been shown in recent studies to have hallmark features of memory cells. Invariant NKT cell (iNKT cell)-mediated antitumor effects indicate that iNKT cells are activated in vivo by vaccination with iNKT cell ligand-loaded CD1d+ cells, but not by vaccination with unbound NKT cell ligand. In such models, it previously was thought that the numbers of IFN-γ-producing cells in the spleen returned to the basal level around 1 wk after the vaccination. In the current study, we demonstrate the surprising presence of effector memory-like iNKT cells in the lung. We found long-term antitumor activity in the lungs of mice was enhanced after vaccination with iNKT cell ligand-loaded dendritic cells. Further analyses showed that the KLRG1+ (Killer cell lectin-like receptor subfamily G, member 1-positive) iNKT cells coexpressing CD49d and granzyme A persisted for several months and displayed a potent secondary response to cognate antigen. Finally, analyses of CDR3β by RNA deep sequencing demonstrated that some particular KLRG1+ iNKT-cell clones accumulated, suggesting the selection of certain T-cell receptor repertoires by an antigen. The current findings identifying effector memory-like KLRG1+ iNKT cells in the lung could result in a paradigm shift regarding the basis of newly developed extrathymic iNKT cells and could contribute to the future development of antitumor immunotherapy by uniquely energizing iNKT cells. [ABSTRACT FROM AUTHOR]

Published
2014
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22. Accelerated chemically induced tumor development mediated by CD4+CD+25 regulatory I cells in wild-type hosts.

Author

Nishikawa, Hiroyoshi, Kato, Takuma, Tawara, Isao, Takemitsu, Tetsushi, Saito, Kanako, Wang, Linan, Ikarashi, Yoshinori, Wakasugi, Hiro, Nakayama, Toshinori, Taniguchi, Masaru, Kuribayashi, Kagemasa, Old, Lloyd J., and Shiku, Hiroshi

Subjects
TUMORS, T cells, IMMUNIZATION, ANTIGENS, KILLER cells, CHEMICAL carcinogenesis
Abstract

We examined the role of CD4+CD25+ regulatory T cells in the development of 3-methylcholanthrene (MCA)-induced tumors. Immunization of wild-type BALB/c mice with a series of SEREX (serological identification of antigens by recombinant expression cloning)- defined broadly expressed self-antigens results in the development of highly active CD4+CD25+ regulatory T cells. Accelerated tumor development was observed in mice immunized with self-antigens and was abolished by antibody-mediated depletion of CD4+ cells or CD25+ T cells. A similar acceleration of tumorigenesis was also observed in mice adoptively transferred 2 or 4 weeks after MCA injection with CD4+CD25+ T cells derived from mice immunized with DnaJ-like 2, one of these self-antigens. Experiments with Jα281-/- mice lacking invariant natural killer (INK) T cells indicated that iNK T cells, known for their protective role in the development of MCA- induced tumors, were suppressed in immunized hosts. NK cells, also known to play a protective role in MCA induced-tumorigenesis, were also suppressed in mice immunized with serologically defined self- antigens in a CD4+CD25+ cell-dependent manner. We propose that CD4+CD25+ regulatory I cells generated by immunization with these self-antigens enhance susceptibility to MCA induced-tumorigenesis by down-regulating INK T and NK reactivity, and suggest that these observations provide direct evidence for the existence of cancer immunosurveillance in this system of chemical carcinogenesis. [ABSTRACT FROM AUTHOR]

Published
2005
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23. CD4[sup +] CD25[sup +] T cells responding to serologically defined autoantigens suppress antitumor immune responses.

Author

Nishikawa, Hiroyoshi, Kato, Takuma, Tanida, Koji, Hiasa, Atsunori, Tawara, Isao, Ikeda, Hiroaki, Ikarashi, Yoshinori, Wakasugi, Hiro, Kronenberg, Mitchell, Nakayama, Toshinori, Taniguchi, Masaru, Kuribayashi, Kagemasa, Old, Lloyd J., and Shiku, Hiroshi

Subjects
T cells, ANTIGENS, AUTOIMMUNITY
Abstract

Examines the suppression of antitumor immune responses by T lymphocytes responding to serologically defined autoantigens. Molecular cloning, transfer of T lymphocytes; Enhancement of pulmonary metastasis in hosts immunized with wild type antigens; Role of serological identification of antigens by recombitant expression cloning-defined autoantigens in antitumor immune responses.

Published
2003
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24. Essential requirement of an invariant V-alpha-14 t cell antigen receptor expression in the...

Author

Taniguchi, Masaru and Koseki, Haruhiko

Subjects
*T cell differentiation, *ANTIGENS
Abstract

Investigates the role of V-alpha-14/V-beta-8 t cell antigen receptor (TCR) in the development of natural killer (NK) t cells. Preferential development of NK cells from V-alpha-14 TCR expression in the absence of endogenous TCR-alpha; CD4 NK T cells as precursor to V-alpha-14 NK T cells.

Published
1996
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25. Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated V...14 NKT...

Author

Kawano, Tetsu, Cui, Junqing, Koezuka, Yasuhiko, Toura, Isao, Kaneko, Yoshikatsu, Sato, Hiroshi, Kondo, Eisuke, Harada, Michishige, Koseki, Haruhiko, Nakayama, Toshinori, Yanaka, Yujiro, and Taniguchi, Masaru

Subjects
TUMORS, CELLS
Abstract

Asserts that one of the effector functions of ...-GalCer-activated V...14 NKT cells, is a target tumor cell lysis mediated by a TCR-independent, NK-like nonspecific mechanism with perforin. Antitumor activity of V...14 NKT cells activated by ...GalCer; How tumor cells are killed by ligand-activated V...14 NKT cells.

Published
1998
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