Search

Your search keyword '"Eccles, Suzanne A."' showing total 4 results
Start Over Author "Eccles, Suzanne A." Journal proceedings of the national academy of sciences of the united states of america
4 results on '"Eccles, Suzanne A."'

3. Plexin-B1 Mutations in Prostate Cancer

Author

Wong, Oscar Gee-Wan, Nitkunan, Tharani, Oinuma, Izumi, Zhou, Chun, Blanc, Veronique, Brown, Richard S. D., Bott, Simon R. J., Nariculam, Joseph, Box, Gary, Munson, Phillipa, Constantinou, Jason, Feneley, Mark R., Klocker, Helmut, Eccles, Suzanne A., Negishi, Manabu, Freeman, Alex, Mastes, John R., and Williamson, Magali

Published
2007
Full Text
View/download PDF

4. Plexin-B1 mutations in prostate cancer.

Author

Oscar Gee-Wan Wong, Nitkunan, Tharani, Oinuma, Izumi, Chun Zhou, Blanc, Veronique, Brown, Richard S. D., Bott, Simon R. J., Nariculam, Joseph, Box, Gary, Munson, Phillipa, Constantinou, Jason, Feneley, Mark R., Klocker, Helmut, Eccles, Suzanne A., Negishi, Manabu, Freeman, Alex, Masters, John R., and Williamson, Magali

Subjects
SEMAPHORINS, PROTEINS, CELL migration, METASTASIS, GENETIC mutation
Abstract

Semaphorins are a large class of secreted or membrane-associated proteins that act as chemotactic cues for cell movement via their transmembrane receptors, plexins. We hypothesized that the function of the semaphorin signaling pathway in the control of cell migration could be harnessed by cancer cells during invasion and metastasis. We now report 13 somatic missense mutations in the cytoplasmic domain of the Plexin-Bi gene. Mutations were found in 89% (8 of 9) of prostate cancer bone metastases, in 41% (7 of 17) of lymph node metastases, and in 46% (41 of 89) of primary cancers. Forty percent of prostate cancers contained the same mutation. Overexpression of the Plexin-Bi protein was found in the majority of primary tumors. The mutations hinder Rac and R-Ras binding and R-RasGAP activity, resulting in an increase in cell motility, invasion, adhesion, and lamellipodia extension. These results identify a key role for Plexin-Bi and the semaphorin signaling pathway it mediates in prostate cancer. [ABSTRACT FROM AUTHOR]

Published
2007
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results