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Your search keyword '"Dmitrovsky, Ethan"' showing total 9 results
Start Over Author "Dmitrovsky, Ethan" Journal proceedings of the national academy of sciences of the united states of america
9 results on '"Dmitrovsky, Ethan"'

1. REPLY TO OEGEMA ET AL. : CFI-400945 and Polo-like kinase 4 inhibition

Author

Kawakami, Masanori, Mustachio, Lisa Maria, Zheng, Lin, Chen, Yulong, Rodriguez-Canales, Jaime, Mino, Barbara, Kurie, Jonathan M., Roszik, Jason, Villalobos, Pamela Andrea, Thu, Kelsie L., Silvester, Jennifer, Cescon, David W., Wistuba, Ignacio I., Mak, Tak W., Liu, Xi, and Dmitrovsky, Ethan

Published
2018

8. Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas.

Author

Yan Ma, Fiering, Steven, Black, Candice, Xi Liu, Ziqiang Yuan, Memoli, Vincent A., Robbins, David J., Bentley, Heather A., Tsongalis, Gregory J., Demidenko, Eugene, Freemantle, Sarah J., and Dmitrovsky, Ethan

Subjects
DYSPLASIA, ADENOCARCINOMA, LUNG cancer, PROGNOSIS, CARCINOGENESIS
Abstract

Cyclin E is a critical G1-S cell cycle regulator aberrantly expressed in bronchial premalignancy and lung cancer. Cyclin E expression negatively affects lung cancer prognosis. Its role in lung carcinogenesis was explored. Retroviral cyclin E transduction promoted pulmonary epithelial cell growth, and small interfering RNA targeting of cyclin E repressed this growth. Murine transgenic lines were engineered to mimic aberrant cyclin E expression in the lung. Wild-type and proteasome degradation-resistant human cyclin E transgenic lines were independently driven by the human surfactant C (SP-C) promoter. Chromosome instability (CIN), pulmonary dysplasia, sonic hedgehog (Shh) pathway activation, adenocarcinomas, and metastases occurred. Notably, high expression of degradation-resistant cyclin E frequently caused dysplasia and multiple lung adenocarcinomas. Thus, recapitulation of aberrant cyclin E expression as seen in human premalignant and malignant lung lesions reproduces in the mouse frequent features of lung carcinogenesis, including CIN, Shh pathway activation, dysplasia, single or multiple lung cancers, or presence of metastases. This article reports unique mouse lung cancer models that replicate many carcinogenic changes found in patients. These models provide insights into the carcinogenesis process and implicate cyclin E as a therapeutic target in the lung. [ABSTRACT FROM AUTHOR]

Published
2007
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9. UBE1L is a retinoid target that triggers PML/RAR α degradation and apoptosis in acute promyelocytic leukemia.

Author

Kitareewan, Sutisak, Pitha-Rowe, Ian, Sekula, David, Lowrey, Christopher H., Nemeth, Michael J., Golub, Todd R., Freemantle, Sarah J., and Dmitrovsky, Ethan

Subjects
MYELOID leukemia, TRETINOIN
Abstract

Examines the all-trans-retinoic acid (RA) treatment in acute promyelocytic leukemia. Details on the microarray analyses in ubiquitin activating enzymes; Capability in mediating transcriptional response to RA; Promotion of ubiquitination and cyclin degradation in retinoid-induced differentiation.

Published
2002
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