1. β-Amyloid accumulation in the human brain after one night of sleep deprivation.
- Author
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Shokri-Kojori E, Wang GJ, Wiers CE, Demiral SB, Guo M, Kim SW, Lindgren E, Ramirez V, Zehra A, Freeman C, Miller G, Manza P, Srivastava T, De Santi S, Tomasi D, Benveniste H, and Volkow ND
- Subjects
- Adult, Aged, Alzheimer Disease diagnostic imaging, Alzheimer Disease genetics, Alzheimer Disease metabolism, Amyloid beta-Peptides genetics, Apolipoproteins E genetics, Female, Genotype, Hippocampus diagnostic imaging, Humans, Male, Middle Aged, Risk Factors, Sleep Deprivation genetics, Thalamus diagnostic imaging, Amyloid beta-Peptides metabolism, Hippocampus metabolism, Sleep Deprivation diagnostic imaging, Sleep Deprivation metabolism, Thalamus metabolism
- Abstract
The effects of acute sleep deprivation on β-amyloid (Aβ) clearance in the human brain have not been documented. Here we used PET and
18 F-florbetaben to measure brain Aβ burden (ABB) in 20 healthy controls tested after a night of rested sleep (baseline) and after a night of sleep deprivation. We show that one night of sleep deprivation, relative to baseline, resulted in a significant increase in Aβ burden in the right hippocampus and thalamus. These increases were associated with mood worsening following sleep deprivation, but were not related to the genetic risk (APOE genotype) for Alzheimer's disease. Additionally, baseline ABB in a range of subcortical regions and the precuneus was inversely associated with reported night sleep hours. APOE genotyping was also linked to subcortical ABB, suggesting that different Alzheimer's disease risk factors might independently affect ABB in nearby brain regions. In summary, our findings show adverse effects of one-night sleep deprivation on brain ABB and expand on prior findings of higher Aβ accumulation with chronic less sleep., Competing Interests: Conflict of interest statement: S.D.S. was an employee of Piramal Pharma Inc., which partly supported the radiotracer for this study., (Copyright © 2018 the Author(s). Published by PNAS.)- Published
- 2018
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