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Your search keyword '"Dave, Sandeep S."' showing total 5 results
Start Over Author "Dave, Sandeep S." Journal proceedings of the national academy of sciences of the united states of america
5 results on '"Dave, Sandeep S."'

2. Biomimetic, synthetic HDL nanostructures for lymphoma

Author

Yang, Shuo, Damlano, Marina G., Zhang, Heng, Tripathy, Sushant, Luthi, Andrea J., Rink, Jonathan S., Ugolkov, Andrey V., Singh, Amareshwar T. K., Dave, Sandeep S., Gordon, Leo I., and Thaxton, C. Shad

Published
2013

3. Genetic heterogeneity of diffuse large B-cell lymphoma

Author

Zhang, Jenny, Grubor, Vladimir, Love, Cassandra L., Banerjee, Anjishnu, Richards, Kristy L., Mieczkowski, Piotr A., Dunphy, Cherie, Choi, William, Au, Wing Yan, Srivastava, Gopesh, Lugar, Patricia L, Rizzieri, David A., Lagoo, Anand S., Bernal-Mizrachi, Leon, Mann, Karen P., Flowers, Christopher, Naresh, Kikkeri, Evens, Andrew, Gordon, Leo I., Czader, Magdalena, Gill, Javed I., Hsi, Eric D., Liu, Qingquan, Fan, Alice, Walsh, Katherine, Jima, Dereje, Smith, Lisa L., Johnson, Amy J., Byrd, John C., Luftig, Micah A., Ni, Ting, Zhu, Jun, Chadburn, Amy, Levy, Shawn, Dunson, David, and Dave, Sandeep S.

Published
2013

4. Molecular Subtypes of Diffuse Large B-Cell Lymphoma Arise by Distinct Genetic Pathways

Author

Lenz, Georg, Wright, George W., Emre, N. C. Tolga, Kohlhammer, Holger, Dave, Sandeep S., Davis, R. Eric, Carty, Shannon, Lam, Lloyd T., Shaffer, A. L., Xiao, Wenming, Powell, John, Rosenwald, Andreas, Ott, German, Muller-Hermelink, Hans Konrad, Gascoyne, Randy D., Connors, Joseph M., Campo, Elias, Jaffe, Elaine S., Delabie, Jan, Smeland, Erlend B., Rimsza, Lisa M., Fisher, Richard I., Weisenburger, Dennis D., Chan, Wing C., and Staudt, Louis M.

Published
2008
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5. Biomimetic, synthetic HDL nanostructures for lymphoma.

Author

Shuo Yang, Damiano, Marina G., Heng Zhang, Tripathy, Sushant, Luthi, Andrea J., Rink, Jonathan S., Ugolkov, Andrey V., Singh, Amareshwar T. K., Dave, Sandeep S., Gordon, Leo I., and Thaxton, C. Shad

Subjects
BIOMIMETIC chemicals, NANOSTRUCTURES, LYMPHOMAS, CANCER treatment, B cell lymphoma, HIGH density lipoproteins, NANOPARTICLES
Abstract

New therapies that challenge existing paradigms are needed for the treatment of cancer. We report a nanoparticle-enabled therapeutic approach to B-cell lymphoma using synthetic high density lipoprotein nanoparticles (HDL-NPs). HDL-NPs are synthesized using a gold nanoparticle template to control conjugate size and ensure a spherical shape. Like natural HDLs, biomimetic HDL-NPs target scavenger receptor type B-i, a high-affinity HDL receptor expressed by lymphoma cells. Functionally, compared with natural HDL, the gold NP template enables differential manipulation of cellular cholesterol flux in lymphoma cells, promoting cellular cholesterol efflux and limiting cholesterol delivery. This combination of scavenger receptor type B-i binding and relative cholesterol starvation selectively induces apoptosis. HDL-NP treatment of mice bearing B-cell lymphoma xenografts selectively inhibits B-cell lymphoma growth. As such, HDL-NPs are biofunctional therapeutic agents, whose mechanism of action is enabled by the presence of a synthetic nanotemplate. HDL-NPs are active in B-cell lymphomas and potentially. other malignancies or diseases of pathologic cholesterol accumulation. [ABSTRACT FROM AUTHOR]

Published
2013
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