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174 results on '"DNA Helicases genetics"'

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1. C9orf72-linked arginine-rich dipeptide repeats aggravate pathological phase separation of G3BP1.

2. The ARK2N-CK2 complex initiates transcription-coupled repair through enhancing the interaction of CSB with lesion-stalled RNAPII.

3. Frequent nonhomologous replacement of replicative helicase loaders by viruses in Vibrionaceae .

4. Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer.

5. Unlicensed origin DNA melting by MCV and SV40 polyomavirus LT proteins is independent of ATP-dependent helicase activity.

6. The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways.

7. TGFB2-AS1 inhibits triple-negative breast cancer progression via interaction with SMARCA4 and regulating its targets TGFB2 and SOX2 .

8. Structural insight and characterization of human Twinkle helicase in mitochondrial disease.

9. The CHARGE syndrome ortholog CHD-7 regulates TGF-β pathways in Caenorhabditis elegans .

10. ΔNp63-Senataxin circuit controls keratinocyte differentiation by promoting the transcriptional termination of epidermal genes.

11. Mycobacterium tuberculosis DNA repair helicase UvrD1 is activated by redox-dependent dimerization via a 2B domain cysteine.

12. Integrated genome and transcriptome analyses reveal the mechanism of genome instability in ataxia with oculomotor apraxia 2.

13. CMG helicase can use ATPγS to unwind DNA: Implications for the rate-limiting step in the reaction mechanism.

14. Natural variation identifies SNI1, the SMC5/6 component, as a modifier of meiotic crossover in Arabidopsis .

15. Clutch mechanism of chemomechanical coupling in a DNA resecting motor nuclease.

16. The Srs2 helicase dampens DNA damage checkpoint by recycling RPA from chromatin.

17. Stress granule formation, disassembly, and composition are regulated by alphavirus ADP-ribosylhydrolase activity.

18. The Cockayne syndrome group A and B proteins are part of a ubiquitin-proteasome degradation complex regulating cell division.

19. Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers.

20. Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination.

21. Epstein-Barr virus co-opts TFIIH component XPB to specifically activate essential viral lytic promoters.

22. Asymmetric base-pair opening drives helicase unwinding dynamics.

23. UvrD helicase activation by MutL involves rotation of its 2B subdomain.

24. CHD4 is essential for transcriptional repression and lineage progression in B lymphopoiesis.

25. DNA helicase RecQ1 regulates mutually exclusive expression of virulence genes in Plasmodium falciparum via heterochromatin alteration.

26. Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response.

27. Genome instability is a consequence of transcription deficiency in patients with bone marrow failure harboring biallelic ERCC6L2 variants.

28. Mechanistic studies of a small-molecule modulator of SMN2 splicing.

29. Massive crossover elevation via combination of HEI10 and recq4a recq4b during Arabidopsis meiosis.

30. HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome.

31. Large domain movements upon UvrD dimerization and helicase activation.

32. FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres.

33. Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.

34. SHPRH regulates rRNA transcription by recognizing the histone code in an mTOR-dependent manner.

35. CMG-Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome.

36. Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA.

37. Pathological Ace2-to-Ace enzyme switch in the stressed heart is transcriptionally controlled by the endothelial Brg1-FoxM1 complex.

38. Binding of EBP50 to Nox organizing subunit p47phox is pivotal to cellular reactive species generation and altered vascular phenotype.

39. DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression.

40. Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest.

41. SMARCAL1 maintains telomere integrity during DNA replication.

42. DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination.

43. Multiple mechanisms limit meiotic crossovers: TOP3α and two BLM homologs antagonize crossovers in parallel to FANCM.

44. Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif.

45. Functionally compromised CHD7 alleles in patients with isolated GnRH deficiency.

46. Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3.

47. Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition.

48. Exome sequencing identifies FANCM as a susceptibility gene for triple-negative breast cancer.

49. Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease.

50. CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference.

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