Search

Your search keyword '"Ma, Hong"' showing total 3 results
Start Over Author "Ma, Hong" Search Limiters Full Text Topic apoptosis Journal proceedings of the national academy of sciences of the united states of america
3 results on '"Ma, Hong"'

3. A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription.

Author

Emami, Katayoon H., Nguyen, Cu, Ma, Hong, Kim, Dae Hoon, Jeong, Kwang Won, Eguchi, Masakatsu, Moon, Randall T., Teo, Jia-Ling, Ohil, Se Wong, Kim, Hak Yeop, Moons, Sung Hwan, Ha, Jong Ryul, and Kahn, Michael

Subjects
GENETIC mutation, COLON cancer, PROTEINS, TRANSCRIPTION factors, HOMOLOGY (Biology), APOPTOSIS
Abstract

Inherited and somatic mutations in the adenomatous polyposis coli occur in most colon cancers, leading to activation of β-catenin-responsive genes. To identify small molecule antagonists of this pathway, we challenged transformed colorectal cells with a secondary structure-templated chemical library, looking for compounds that inhibit a β-catenin-responsive reporter. We identified ICG-001, a small molecule that down-regulates β-catenin/T cell factor signaling by specifically binding to cyclic AMP response element-binding protein. ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer. [ABSTRACT FROM AUTHOR]

Published
2004
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results